Abstract
THE physiological and pharmacological effects of L-glutamate have received much attention since its implication in the aetiology of the “Chinese restaurant syndrome”1–3. Although an excess of L-glutamic acid (GA) as the monosodium salt (MSG) was known to cause retinopathy in experimental animals4–7, brain lesions have been noticed only recently8–10. There seems to be no agreement about its pharmacological and neurophysiological effects in humans11 and experimental animals12.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Schaumburg, H. H., and Byck, R., New Engl. J. Med., 279, 105 (1968).
Ambos, M., Leavitt, N. R., Marmorek, L., and Wolschina, S. B., New Engl. J. Med., 279, 105 (1968).
Schaumburg, H. H., Byck, R., Gerstl, R., and Mashman, J. H., Science, 163, 826 (1969).
Lucas, D. R., and Newhouse, J. P., Amer. Med. Assoc. Arch. Ophthalmol., 58, 193 (1957).
Potts, A. M., Modrell, R. W., and Kingsbury, C., Amer. J. Ophthalmol., 50, 900 (1960).
Freedman, J. K., and Potts, A. M., Invest. Ophthalmol., 1, 118 (1962).
Olney, J. W., J. Neuropathol. Exp. Neurol., 28, 455 (1969).
Olney, J. W., Science, 164, 719 (1969).
Olney, J. W., and Sharpe, L. G., Science, 166, 386 (1969).
Olney, J. W., and Ho, O., Nature, 227, 609 (1970).
Morselli, P. L., and Garattini, S., Nature, 227, 611 (1970).
Adamo, N. J., and Ratner, A., Science, 169, 673 (1970).
Bhagavan, H. N., Coursin, D. B., and Dakshinamurti, K., Arch. Biochem. Biophys., 110, 422 (1965).
Bhagavan, H. N., Maruyama, H., and Coursin, D. B., Abstr. Seventh Intern. Cong. Biochem., Tokyo, 802 (1967).
Bhagavan, H. N., Coursin, D. B., and Stewart, C. N., Life Sci., 8, 299 (1969).
Wiechert, P., and Herbst, A., J. Neurochem., 13, 59 (1966).
Wiechert, P., and Göllnitz, G., J. Neurochem., 15, 1265 (1968).
Wiechert, P., and Göllnitz, G., J. Neurochem., 17, 137 (1970).
Elliot, K. A. C., and van Gelder, N. M., J. Neurochem., 3, 28 (1958).
Kamrin, R. P., and Kamrin, A. A., J. Neurochem., 6, 219 (1961).
Roberts, E., Rothstein, M., and Baxter, C. F., Proc. Soc. Exp. Biol. Med., 97, 796 (1958).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BHAGAVAN, H., COURSIN, D. & STEWART, C. Monosodium Glutamate induces Convulsive Disorders in Rats. Nature 232, 275–276 (1971). https://doi.org/10.1038/232275a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/232275a0
This article is cited by
-
Aspartame and seizures
Amino Acids (1993)
-
Monosodium glutamate induced convulsions in rats: Influence of route of administration, temperature and age
Amino Acids (1991)
-
Glutamate in the mammalian CNS
European Archives of Psychiatry and Clinical Neuroscience (1990)
-
Effects of intraventricular glutamic acid on the acquisition, performance, and extinction of an operant response, and on general activity
Psychopharmacology (1976)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.