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Sunlight-induced Pyrimidine Dimers in Human Cells in Vitro

Abstract

PYRIMIDINE dimers have been implicated in much ultraviolet light induced damage in bacteria1, and it has been shown that they can be induced in mammalian cells with short wavelength ultraviolet light2–7. In placental mammals, pyrimidine dimers are not repaired by direct monomerization by photoreactivating light2,8,9, although a dark repair mechanism, somewhat similar to that found in bacterial cells, has been demonstrated10.

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TROSKO, J., KRAUSE, D. & ISOUN, M. Sunlight-induced Pyrimidine Dimers in Human Cells in Vitro. Nature 228, 358–359 (1970). https://doi.org/10.1038/228358b0

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