Abstract
A single dose of splenic extract is sufficient to induce a high degree of specific unresponsiveness to skin allografts in mice if used in conjunction with antilymphocytic serum. The interval between giving the extract and the antiserum is of great importance, and the unresponsiveness appears to be due to tolerance rather than enhancement.
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BRENT, L., KILSHAW, P. Prolongation of Skin Allograft Survival with Spleen Extracts and Antilymphocytic Serum. Nature 227, 898–900 (1970). https://doi.org/10.1038/227898a0
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DOI: https://doi.org/10.1038/227898a0
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