Homeostasis and Differentiation in Random Genetic Control Networks
Biology Department, University of Cincinnati, Ohio.
*Present address: Committee on Mathematical Biology, University of Chicago, Chicago, Illinois.
THE genome is a complex net of interacting components commonly thought to control homeostasis and differentiation through precisely constructed control circuits among the genes1–6. But I have found what seems to be a new class of dynamically stable systems, which suggests that even haphazardly constructed control nets of high molecular specificity undergo homeostasis and differentiation.
||Apter, M. J., Cybernetics and Development (Pcrgamon Press, Oxford, 1966).
||Bonner, J. F., The Molecular Biology of Development (Oxford University Press, London, 1965).
||Jacob, F., and Monod, J., Twenty-first Symp. Soc. Study of Development and Growth (Academic Press, London, 1963).
||Sugita, M., J. Theoret. Biol., 4, 179 (1963).
||Kauffman, S. A., J. Theoret. Biol., 17, 483 (1967).
||Goodwin, B. C., Temporal Organization in Cells (Academic Press, London. 1963).
||Kauffman, S. A., J. Theoret. Biol., 22, 437 (1969).
||Bretscher, M. S., Nature, 217, 509 (1967).
||Bullough, W. S., The Evolution of Differentiation (Academic Press. London. 1968).
© 1969 Nature Publishing Group