Abstract
CERTAIN platinum compounds completely but reversibly iiihibit cell division in Gram-negative rods1–4. These compounds have been tested for antitumour activity and we report some of the preliminary results. The platinum compounds inhibit sarcoma 180 and leukaemia L1210 in mice.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Rosenberg, B., VanCamp, L., and Krigas, T., Nature, 205, 698 (1965).
Rosenberg, B., Renshaw, E., VanCamp, L., Hartwick, J., and Drobnik, J., J. Bact., 93, 716 (1967).
Rosenberg, B., VanCamp, L., Grimley, E., and Thomson, A. J., J. Biol. Chem., 242, 1347 (1967).
Renshaw, E., and Thomson, A. J., J. Bact., 94, 1915 (1967).
Cancer Chemotherapy Rep., 25 (1962).
Goldin, A., Goldberg, B., Ortega, L. G., Fugman, R., Faiman, F., and Schoenbach, E. B., Cancer, 2, 865 (1949).
Venditti, J. M., and Abbott, B. J., Lloydia, 30, 332 (1967).
Collier, W. A., and Kraus, F., Z. Krebsforsch., 34, 526 (1931).
Taylor, A., and Carmichael, N., Univ. Texas Publ. No. 5314, Biochem. Inst. Studies 5, Cancer Studies 2, 36 (1953).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
ROSENBERG, B., VANCAMP, L., TROSKO, J. et al. Platinum Compounds: a New Class of Potent Antitumour Agents. Nature 222, 385–386 (1969). https://doi.org/10.1038/222385a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/222385a0
This article is cited by
-
Pharmacodynamics and biodistribution of [195mPt]cisplatin(CISSPECT®) in head and neck squamous cell carcinoma
EJNMMI Research (2024)
-
Methionine enkephalin (MENK) protected macrophages from ferroptosis by downregulating HMOX1 and ferritin
Proteome Science (2024)
-
Synthesis, anticancer activity, and molecular docking of half-sandwich iron(II) cyclopentadienyl complexes with maleimide and phosphine or phosphite ligands
Scientific Reports (2024)
-
A computational insight on the aromatic amino acids conjugation with [Cp*Rh(H2O)3]2+ by using the meta-dynamics/FMO3 approach
Journal of Molecular Modeling (2024)
-
Primary processes in photophysics and photochemistry of a potential light-activated anti-cancer dirhodium complex
Photochemical & Photobiological Sciences (2024)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.