Abstract
WHEN considering the possibility of marking cell populations with a short-lived, positron-emitting nuclide, carbon-11 (11C, T½ = 20.5 min) appears to be suitable because, when produced through nuclear reactions in proton-irradiation of cells, it may be expected to react chemically with the intracellular material in the same way as it does with simpler organic systems1. Therefore it was decided to study to what extent 11C produced during irradiation of citrate blood is fixed in the cellular fraction of the target. This report describes observations of the localization of 11C in human blood irradiated with 185-MeV protons. The radioactivity of whole blood, blood corpuscles and supernatant was followed during the course of a step-wise washing procedure after irradiation.
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References
MacKay, C., and Wolfgang, R., Radiochim. Acta, 1, 42 (1962).
Larsson, B., Brit. J. Radiol., 34, 143 (1961).
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LARSSON, B., GRAFFMAN, S. & JUNG, B. Fixation of Carbon-11 in the Cells of Proton-irradiated Blood. Nature 207, 543–544 (1965). https://doi.org/10.1038/207543a0
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DOI: https://doi.org/10.1038/207543a0
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