Abstract
THE role of carbonyl chloride in the production of uraemic coma has been emphasized in previous publications1,2. It has been further demonstrated that urea reacting with ammonium chloride in vivo produces carbonyl chloride with the liberation of ammonia. In view of the enormous number of cases of uraemia already handled by the author it appears that a plausible suggestion with regard to the biochemical steps involved in the production of carbonyl chloride and associated compounds is called for.
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References
Sen, D. K., Nature, 193, 889 (1962).
Sen, D. K., Nature, 201, 1334 (1964).
Krebs, H. A., The Enzymes, 2, 866 (1951).
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SEN, D. Carbonyl Chloride Cycle in Uraemia. Nature 205, 908–909 (1965). https://doi.org/10.1038/205908b0
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DOI: https://doi.org/10.1038/205908b0
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