Abstract
IT was originally proposed by Astbury1 that muscular contraction was due to coiling or folding of the contractile proteins. A model of the structure of muscle sarcomere was recently proposed by A. F. Huxley and Neidergerke2 and by H. E. Huxley and Hanson3; their model shows that filaments of action and myosin slide past each other during contraction. A. F. Huxley4 proposed a hypothesis of contraction in which it is assumed that active shortening or the development of tension is brought about by generation of relative translational forces between actin and myosin filaments at a series of points in the region of overlap.
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References
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Huxley, H. E., and Hanson, J., Ann. N.Y. Acad. Sci., 81, 403 (1959).
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SINGH, I. Intimate Nature of Muscular Contraction. Nature 196, 172–173 (1962). https://doi.org/10.1038/196172a0
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DOI: https://doi.org/10.1038/196172a0
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