Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Gene Action in the X-chromosome of the Mouse (Mus musculus L.)

Abstract

Ohno and Hauschka1 showed that in female mice one chromosome of mammary carcinoma cells and of normal diploid cells of the ovary, mammary gland and liver was heteropyknotic. They interpreted this chromosome as an X-chromosome and suggested that the so-called sex chromatin was composed of one heteropyknotic X-chromosome. They left open the question whether the heteropyknosis was shown by the paternal X-chromosome only, or the chromosome from either parent indifferently.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Ohno, S., and Hauschka, T. S., Cancer Res., 20, 541 (1960).

    CAS  PubMed  Google Scholar 

  2. Welshons, W. J., and Russell, L. B., Proc. U.S. Nat. Acad. Sci., 45, 560 (1959).

    Article  ADS  CAS  Google Scholar 

  3. Fraser, A. S., Sobey, S., and Spicer, C. C., J. Genet., 51, 217 (1953).

    Article  Google Scholar 

  4. Lyon, M. F., J. Hered., 51, 116 (1960).

    Article  Google Scholar 

  5. Dickie, M. M., J. Hered., 45, 158 (1954).

    Article  Google Scholar 

  6. Phillips, R. J. S., Genet. Res. (in the press).

  7. Russell, L. B., and Bangham, J. W., Genetics, 44, 532 (1959).

    Google Scholar 

  8. Russell, L. B., and Bangham, J. W., Genetics, 45, 1008 (1960).

    Google Scholar 

  9. Falconer, D. S., Z. indukt. Abstamm. u. Vererblehre, 85, 210 (1953).

    CAS  Google Scholar 

  10. Garber, E. D., Proc. U.S. Nat. Acad. Sci., 38, 876 (1952).

    Article  ADS  CAS  Google Scholar 

  11. Phillips, R. J. S., Z. indukt. Abstamm. u. Vererblehre, 86, 322 (1954).

    CAS  Google Scholar 

  12. Austin, C. R., and Amoroso, E. C., Exp. Cell Res., 13, 419 (1957).

    Article  CAS  Google Scholar 

  13. Park, W. W., J. Anat., 91, 369 (1957).

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Ohno, S., Kaplan, W. D., and Kinosita, R., Exp. Cell Res., 18, 415 (1959).

    Article  CAS  Google Scholar 

  15. Ohno, S., Kaplan, W. D., and Kinosita, R., Exp. Cell Res., 19, 417 (1960).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

LYON, M. Gene Action in the X-chromosome of the Mouse (Mus musculus L.). Nature 190, 372–373 (1961). https://doi.org/10.1038/190372a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/190372a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing