Abstract
ALTHOUGH the part played by metals in non-enzymatic transaminations is known, its role in the enzymatic reaction of this type is still to be proved. Aluminium, nickel, copper and iron are known to catalyse the non-enzymatic reaction between an amino-acid and pyridoxal, or a keto-acid and pyridoxamine. Recently, Fasella et al. 1 have isolated the intermediates involved. This preliminary communication reports the possibility of iron (in its reduced state) being involved in the enzymatic transamination.
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References
Fasella, P., Lis, H., Siliprandi, N., and Baglioni, C., Biochim. Biophys. Acta, 23, 417 (1957).
“Amino-acid Metabolism”, Symposium, McCollum-Pratt Institute, p. 56 (1955).
Tonhazy, N. E., White, N. G., and Umbreit, W. W., Arch. Biochem., 28, 36 (1950).
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PATWARDHAN, M. Role of Ferrous Iron in Enzymatic Transamination. Nature 181, 187 (1958). https://doi.org/10.1038/181187a0
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DOI: https://doi.org/10.1038/181187a0
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