Abstract
THE mitochondrial membrane has a limited ability to retain nucleotides and other co-factors like Mg++ which are essential for maintaining normal respiration and efficient coupled phosphorylation1. Exposure to hypotonic conditions, ageing, other environmental alterations and physiological states cause swelling of the mitochondria accompanied by biochemical modifications, such as loss of Mg++ and of acid-soluble nucleotides with absorption maximum at 260 mµ, increase in adenosine triphosphatase activity and dissociation of phosphorylation from oxidation1–3. Conditions favourable to oxidative phosphorylation or the presence of adenosine monophosphate apparently protect the mitochondria against this damage1,4.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Siekevitz, P., and Potter, V. R., J. Biol. Chem., 215, 221, 237 (1955).
Dianzani, M. U., Biochim. Biophys. Acta, 14, 514 (1954).
Hunter, F. E., and Ford, L., J. Biol. Chem., 216, 357 (1955).
Fonnesu, A., and Davies, R. E., Biochem. J., 61, vi (1955).
Maley, G. I., and Lardy, H. A., J. Biol. Chem., 215, 377 (1955).
Chernick, S. S., Moe, J. G., Rodnan, G. P., and Schwarz, K., J. Biol. Chem., 217, 829 (1955).
Fatterpaker, P., Marfatia, U., and Sreenivasan, A., Nature, 176, 165 (1955).
Kasbekar, D. K., Rege, D. V., and Sreenivasan, A. (previous communication).
Schneider, W. C., and Hogeboom, G. H., J. Biol. Chem., 183, 123 (1950).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
KASBEKAR, D., SREENIVASAN, A. Lability of Intramitochondrial Components in Experimental Liver Injury. Nature 178, 989–990 (1956). https://doi.org/10.1038/178989b0
Issue Date:
DOI: https://doi.org/10.1038/178989b0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
