Abstract
SINCE thyroxine is known to decrease the efficiency with which phosphorylation is coupled to respiration1, the possibility suggests itself that vitamin B12 may function in hyperthyroidism by restoration, in part at least, of the energy-requiring functions of impaired cells. This has now been examined by a study of the following conjugation systems: acetylation of p-aminobenzoic acid, benzoylation of glycine, and synthesis of glutathione.
Similar content being viewed by others
Article PDF
References
DuToit, C. H., “Phosphorus Metabolism”, 2, 597 (Johns Hopkins Press, 1952).
Riggs, T. R., and Hegsted, D. M., J. Biol. Chem., 172, 539 (1948).
Chantrenne, H., J. Biol. Chem., 189, 227 (1951).
Grunert, R. R., and Phillips, P. H., Arch. Biochem. and Biophys., 30, 217 (1951).
Mortensen, R. A., J. Biol. Chem., 204, 240 (1953).
Kano, A. K., Anderson, J. A., Hougham, D. F., and Charkey, L. W., Proc. Soc. Exp. Biol. and Med., 86, 8 (1954).
Ling, C. T., and Chow, B. F., J. Biol. Chem., 206, 797 (1954).
Oginsky, E. L., Smith, P. H., Tonhazy, N. E., Umbreit, W. M., Lichstein, H. C., and Carson, S. F., J. Bact., 61, 581 (1951).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
FATTERPAKER, P., MARFATIA, U. & SREENIVASAN, A. Protective Action of Vitamin B12 in the Hyperthyroid Rat. Nature 176, 165 (1955). https://doi.org/10.1038/176165a0
Issue Date:
DOI: https://doi.org/10.1038/176165a0
This article is cited by
-
Changes in folic acid metabolism during administration of vitamin B12 antimetabolites and thyroid hormones
Bulletin of Experimental Biology and Medicine (1968)
-
Effect of vitamin B12 and combined administration of vitamin B12 and thyroid extract on the thyroid gland of rats during reparative regeneration after surgical trauma
Bulletin of Experimental Biology and Medicine (1966)
-
Lability of Intramitochondrial Components in Experimental Liver Injury
Nature (1956)
-
Protective Action of Vitamin B12 in the Hyperthyroid Rat
Nature (1956)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.