Abstract
SEVERAL recent reports have recorded an influence of folic acid on biological methylation1,2, creatine excretion3 and choline oxidase activity4. A metabolic relationship between vitamin B12, choline and methionine has also been established2,5. These and other observed general inter-relationships between folic acid and vitamin B126 suggested the present studies on the transmethylation of glycocyamine by liver enzymes (cf. ref. 7) and on in vivo formation of creatine.
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FATTERPAKER, P., MARFATIA, U. & SREENIVASAN, A. Influence of Folic Acid and Vitamin B12 on Formation of Creatine in vitro and in vivo. Nature 167, 1067–1068 (1951). https://doi.org/10.1038/1671067a0
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DOI: https://doi.org/10.1038/1671067a0
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