Abstract
A NEW blood group character, designated as 'Lewis', was first described by Mourant1, who found that the blood of 25 per cent of English people contained the Lewis factor, and that this group character is independent serologically of the ABO, MN, Rh, P, Lutheran and Kell systems. Somewhat later, Andresen2 described 'anti-L sera' which are now known to be anti-Lewis sera. These sera agglutinated the red cells of 21 per cent of adult Danes and the cells of about 70 per cent of Danish children less than seven months old. Andresen put forward the view that the Lewis blood group was inherited by means of two allelomorphic genes L and 1, the three possible genotypes being LL, LI and II. The data observed indicated that anti-Lewis serum agglutinates the red cells of adults if they are of genotype LL only, whereas in young children the genotype LI is also detectable.
Similar content being viewed by others
Article PDF
References
Mourant, A. E., Nature, 158, 237 (1946).
Andresen, P. H., Acta Path. Microbiol. Scand., 24, 616 (1947).
Morgan, W. T. J., and Waddell, M. B. R., Brit. J. Exp. Path., 26, 387 (1945).
Jonsson, B., Acta Path. Microbiol. Scand., Supp., 54, 456 (1944).
Grubb, B., (in preparation).
Witebsky, E., and Klendshoj, N. C., J. Exp. Med., 73, 655 (1941).
Morgan, W. T. J., and Watkins, W. M., Brit. J. Exp. Path., 29, 159 (1948).
Annison, E. F., and Morgan, W. T. J. (unpublished observations).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GRUBB, R. Correlation between Lewis Blood Group and Secretor Character in Man. Nature 162, 933 (1948). https://doi.org/10.1038/162933a0
Issue Date:
DOI: https://doi.org/10.1038/162933a0
This article is cited by
-
Lewis and AB0 blood group-phenotypes in periodontitis, cardiovascular disease, obesity and stroke
Scientific Reports (2019)
-
Observations on the Lewisa and Lewisb activity of erythrocytes
International Journal of Legal Medicine (1995)
-
Expression of Lewis histo-blood group glycolipids in the plasma of individuals of Le(a+b+) and partial secretor phenotypes
Glycoconjugate Journal (1994)
-
Multiplicative effect of hyperpepsinogenemia I and non-secretor status on the risk of duodenal ulcer in siblings
Gastroenterologia Japonica (1990)
-
The distribution of the ABH secretors with myotonic dystrophy in San-in district of Japan
Japanese journal of human genetics (1981)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.