Abstract
EXPERIMENTS carried out in this laboratory1 have shown that 1:2:5:6-dibenzanthracene and 5:6-cyclo-penteno-1:2-benzanthracene are the most carcinogenic of pure compounds yet described. The action of these compounds and of certain non-carcinogenic hydrocarbons on the oxidising enzymes of yeast and muscle has been studied. The carcinogenic and other hydrocarbons dissolved in benzene or toluene were shaken up with enzyme preparations, and the effect on the activity of the enzyme measured. In no case was indophenol oxidase of yeast or muscle affected by any such treatment.
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References
The Production of Cancer by Pure Hydrocarbons, (Pt. 1) by J. W. Cook, I. Hieger, E. L. Kennaway, and W. V. Mayneord, (Pt. 2) by J. W. Cook, Proc. Roy. Soc., B (in the press).
J. W. Cook Unpublished results.
Biochem. J., 22, 689; 1928.
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BOYLAND, E. Inhibition of Enzymes by Carcinogenic Compounds. Nature 130, 274–275 (1932). https://doi.org/10.1038/130274b0
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DOI: https://doi.org/10.1038/130274b0
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