Browse Articles

  • Editorial |

    As officials meet in Bonn to swap stories on progress towards the Paris goals, only emissions cuts will guarantee a happy ending.

  • Letter |

    The HOIL-1 component of the LUBAC ubiquitin ligase complex is required for LUBAC activity, which prevents lethality during embryogenesis by preventing aberrant TNFR1-mediated endothelial cell death and RIPK1-mediated defects in haematopoiesis.

    • Nieves Peltzer
    • , Maurice Darding
    • , Antonella Montinaro
    • , Peter Draber
    • , Helena Draberova
    • , Sebastian Kupka
    • , Eva Rieser
    • , Amanda Fisher
    • , Ciaran Hutchinson
    • , Lucia Taraborrelli
    • , Torsten Hartwig
    • , Elodie Lafont
    • , Tobias L. Haas
    • , Yutaka Shimizu
    • , Charlotta Böiers
    • , Aida Sarr
    • , James Rickard
    • , Silvia Alvarez-Diaz
    • , Michael T. Ashworth
    • , Allison Beal
    • , Tariq Enver
    • , John Bertin
    • , William Kaiser
    • , Andreas Strasser
    • , John Silke
    • , Philippe Bouillet
    •  & Henning Walczak
  • Article |

    Cooperation between a chiral hydrogen-bond-donor catalyst and a strong Lewis-acid promoter in an SN1-type reaction mediates the formation of tertiary carbocations and enables control over enantioselectivity and product distribution.

    • Alison E. Wendlandt
    • , Prithvi Vangal
    •  & Eric N. Jacobsen
  • Letter |

    A cryo-EM structure of an initiation complex of HIV-1 reverse transcriptase sheds light on the initiation of reverse transcription of viral RNA.

    • Kevin P. Larsen
    • , Yamuna Kalyani Mathiharan
    • , Kalli Kappel
    • , Aaron T. Coey
    • , Dong-Hua Chen
    • , Daniel Barrero
    • , Lauren Madigan
    • , Joseph D. Puglisi
    • , Georgios Skiniotis
    •  & Elisabetta Viani Puglisi
  • Letter |

    The structure of alternative complex III, a key enzyme in the bacterial electron transport chain, is reported both alone and as a supercomplex with an aa3-type cytochrome c oxidase.

    • Chang Sun
    • , Samir Benlekbir
    • , Padmaja Venkatakrishnan
    • , Yuhang Wang
    • , Sangjin Hong
    • , Jonathan Hosler
    • , Emad Tajkhorshid
    • , John L. Rubinstein
    •  & Robert B. Gennis
  • Editorial |

    A wave of anti-Jewish prejudice is once again washing over schools and universities. There is no excuse not to call out this vile behaviour.

  • News & Views |

    Two experiments have demonstrated entanglement — non-classical correlations — between remote mechanical systems comprising billions of atoms. The results could advance our understanding of quantum physics.

    • Andrew Armour
  • Letter |

    Quantum entanglement is demonstrated in a system of massive micromechanical oscillators coupled to a microwave-frequency electromagnetic cavity by driving the devices into a steady state that is entangled.

    • C. F. Ockeloen-Korppi
    • , E. Damskägg
    • , J.-M. Pirkkalainen
    • , M. Asjad
    • , A. A. Clerk
    • , F. Massel
    • , M. J. Woolley
    •  & M. A. Sillanpää
  • Article |

    High-resolution cryo-electron microscopy structures of the membrane-pore-forming domain of the mouse gasdermin GSDMA3 show that it forms pores with 26-, 27- or 28-fold symmetry and indicate that it may also form a parallel, soluble, pre-pore ring structure.

    • Jianbin Ruan
    • , Shiyu Xia
    • , Xing Liu
    • , Judy Lieberman
    •  & Hao Wu
  • Letter |

    During continent collision and associated mountain building, a surprisingly large volume of the lower crust is shown to be affected by earthquake aftershocks, producing a top-down effect on crustal geodynamics.

    • Bjørn Jamtveit
    • , Yehuda Ben-Zion
    • , François Renard
    •  & Håkon Austrheim
  • Letter |

    An optical-frequency synthesizer based on stabilized frequency combs has been developed utilizing chip-scale devices as key components, in a move towards using integrated photonics technology for ultrafast science and metrology.

    • Daryl T. Spencer
    • , Tara Drake
    • , Travis C. Briles
    • , Jordan Stone
    • , Laura C. Sinclair
    • , Connor Fredrick
    • , Qing Li
    • , Daron Westly
    • , B. Robert Ilic
    • , Aaron Bluestone
    • , Nicolas Volet
    • , Tin Komljenovic
    • , Lin Chang
    • , Seung Hoon Lee
    • , Dong Yoon Oh
    • , Myoung-Gyun Suh
    • , Ki Youl Yang
    • , Martin H. P. Pfeiffer
    • , Tobias J. Kippenberg
    • , Erik Norberg
    • , Luke Theogarajan
    • , Kerry Vahala
    • , Nathan R. Newbury
    • , Kartik Srinivasan
    • , John E. Bowers
    • , Scott A. Diddams
    •  & Scott B. Papp
  • Comment |

    Difficult questions will be raised as models of the human brain get closer to replicating its functions, explain Nita A. Farahany, Henry T. Greely and 15 colleagues.

    • Nita A. Farahany
    • , Henry T. Greely
    • , Steven Hyman
    • , Christof Koch
    • , Christine Grady
    • , Sergiu P. Pașca
    • , Nenad Sestan
    • , Paola Arlotta
    • , James L. Bernat
    • , Jonathan Ting
    • , Jeantine E. Lunshof
    • , Eswar P. R. Iyer
    • , Insoo Hyun
    • , Beatrice H. Capestany
    • , George M. Church
    • , Hao Huang
    •  & Hongjun Song
  • Letter |

    Ohmic losses in plasmonic devices can be reduced by exploiting ‘resonant switching’, in which light couples to surface plasmon polaritons only when in resonance and bypasses them otherwise.

    • Christian Haffner
    • , Daniel Chelladurai
    • , Yuriy Fedoryshyn
    • , Arne Josten
    • , Benedikt Baeuerle
    • , Wolfgang Heni
    • , Tatsuhiko Watanabe
    • , Tong Cui
    • , Bojun Cheng
    • , Soham Saha
    • , Delwin L. Elder
    • , Larry. R. Dalton
    • , Alexandra Boltasseva
    • , Vladimir M. Shalaev
    • , Nathaniel Kinsey
    •  & Juerg Leuthold
  • Letter |

    Remote quantum entanglement is demonstrated in a micromachined solid-state system comprising two optomechanical oscillators across two chips physically separated by 20 cm and with an optical separation of around 70 m.

    • Ralf Riedinger
    • , Andreas Wallucks
    • , Igor Marinković
    • , Clemens Löschnauer
    • , Markus Aspelmeyer
    • , Sungkun Hong
    •  & Simon Gröblacher