Review, News & Views, Perspectives, Hypotheses and Analyses in 2004

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  • Damaged DNA must be removed with the utmost precision, as mistakes are costly. The structure of a repair enzyme bound to its substrate provides a welcome clue to how this is achieved.

    • Tomas Lindahl
    News & Views
  • A long-awaited breakthrough has been made in lattice quantum chromodynamics — a means of calculating the effect of the strong force between sub-atomic particles that could, ultimately, unveil new physics.

    • Ian Shipsey
    News & Views
  • The silicon chip has been the mainstay of the electronics industry and it may similarly come to dominate photonics. A key component — a high-frequency optical modulator — has now been fabricated.

    • Graham T. Reed
    News & Views
  • In an echo of events that unfolded earlier in the West, declines of vulture populations in the Indian subcontinent are linked to an environmental poison. Three species of these birds approach extinction.

    • Robert Risebrough
    News & Views
  • The causes of defects in the blood system of newborn babies can be hard to establish if the errors are not inherited. An elegant approach has identified a gene that can encourage new blood vessels to grow.

    • Diether Lambrechts
    • Peter Carmeliet
    News & Views
  • Some species of plant will prefer a world with higher levels of atmospheric carbon dioxide. When those species are invasive pests, the invaders may well flourish at the expense of the native vegetation.

    • Peter D. Moore
    News & Views
  • Ammonia is produced industrially by combining nitrogen and hydrogen gas, catalysed over a solid iron surface. How about a catalytic reaction that could take place in solution? The first steps have now been taken.

    • Michael D. Fryzuk
    News & Views
  • Nerve transmission depends on voltage-gated ion-channel proteins, which in turn depend on the behaviour of a membrane domain called the voltage sensor. Therein lies the latest episode in a continuing story.

    • Robert O. Blaustein
    • Christopher Miller
    News & Views
  • Comparative genetic linkage studies in rats, mice and humans have finally identified a key component of vitamin K metabolism that is targeted by the commonest anticoagulant drugs in use today.

    • J. Evan Sadler
    News & Views
  • A surprising number of the icy objects in the Kuiper belt exist in pairs, or binaries. A new model proposes that these two-body systems were created through three-body interactions.

    • Joseph A. Burns
    News & Views
  • During egg and sperm production, the two copies of a duplicated chromosome must be bound together until it is time for their separation. A protein that protects this chromosomal glue has now been discovered.

    • Robin Allshire
    News & Views
  • Plants protect themselves against attacks by microorganisms in various ways. In some circumstances at least, it turns out that they enlist the help of mutualistic fungi in defence of the home front.

    • Keith Clay
    News & Views