Outlook in 2012

Growing evidence shows that pregnant patients can beat breast cancer without endangering the unborn child.

Specific research and treatment of breast cancer in men has been neglected and deserves greater attention, says Valerie Speirs.

Researchers are turning to breast density to help predict cancer risk.

The system for clinical trials must be redesigned if there is to be a decline in breast cancer metastasis, argues Patricia S. Steeg.

Physical activity has numerous proven benefits, and its long-contested ability to keep cancer at bay is now being put to the test.

If detected early, most cases of breast cancer seem to be curable. But the tumour's deadly offspring could be sleeping in the body.

The number of people living with, and dying of, diabetes across the world is shocking: 90 million Chinese live with diabetes and 1.3 million died in 2011; 23% of Qatari adults have developed diabetes. Here we chart the extent of the global epidemic and present some of the implications for national governments by Tony Scully.

Artificial pancreases promise to take the decision-making — and human mistakes — out of managing type 1 diabetes.

Promising drugs to treat diabetes stumble in the latter stages of clinical testing. Thomas Mandrup-Poulsen explains why — and how to fix it.

Decades of study into the causes of diabetes have produced no definitive answers.

While type 1 diabetes might be promising ground for a vaccine, the most effective way to avoid type 2 remains good old-fashioned diet and exercise.

Your gut microflora might be aiding and abetting diabetes.

Recent research suggests that the fight against type 1 diabetes is focusing too narrowly on the adaptive immune system, says Carla Greenbaum.

Epigenetics and lifestyle are conspiring to inflict a massive epidemic of type 2 diabetes in the subcontinent.

In type 1 diabetes, the immune system goes haywire and depletes insulin-producing cells. Drugs that interfere with this process could one day reverse the disease's course.

Nature Outlook maps the challenges in tackling the malaria epidemic.

Nine experts give their opinion on the 'known unknowns' in malaria research.

The nearly century-long search for a malaria vaccine might end in the bottom of a cup.