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Featured this week — an ultra-low-noise patch-clamp amplifier, a 120-channel signal-stacking seismograph and alpha/beta liquid scintillation counters that feature automatic crossover optimization and ultra-low-level counting.
New products featured this week include a gel designed specifically for the detection of point mutations and a nonradioactive assay for detecting HIV DMA.
Scanning tunnelling microscopy and atomic force microscopy, one scanning the tunnelling current and the other the repulsive atomic force between sample and probe, can give high-quality surface topographies of proteins, which have been difficult to obtain by more conventional methods such as transmission electron microscopy.
Proteins separated on sodium dodecyl sulphate-polyacrylamide gels can be detected in subpicogram quantities by radioactivation of silver-treated protein molecules.
Oligonucleotide-immobilized plastic plates provide a rapid and easy-to-use tool for use in mRNA research, including the long-term storage, amplification and detection of the specific message, in vitro synthesis of both strands of sense and antisense mRNA, and ligation of cDNA to other DNA molecules.
New products in the spectroscopic arena include an advanced spectral library system for infrared spectroscopy and a fast-scanning UV/visible spectrophotometer that features reverse optics.
Featured this week— new Microbial Strain Data Network developments, an artificial capillary cell culture system that is designed to simulate in vivo growth conditions and an anti-mycoplasmal antibiotic to add to your armoury.
The increasing diversity of new cell cultures is seriously stretching the capabilities of traditional methods of identification. DNA fingerprinting is set to play an important role in increasing confidence in the authenticity of cultures in research and industry.
The field of capillary electrophoresis has undergone rapid development over the past 10 years. Many advances have been made, but there are still some problems that must be addressed before the technique can reach its full potential.
Over 900 exhibitors will be represented at Analytica '92, the 13th International Trade Fair for Biochemical and Instrumental Analysis to be held next week in Munich, Germany.
A competent cell kit for improved protein expression, a new glycan release and preparation system for glycobiology research and a molecular modelling package that turns a desktop PC into a three-dimensional molecular modelling and analysis system - new tools for protein engineering.
Homology modelling software can predict the structure of a newly sequenced protein by incorporating conformational similarity information from related proteins for which atomic coordinates are known. Models built using structural data are more reliable than those based on sequence alignments alone.
The large surfaces of protein antigens that interact with antibody-combining sites can be determined using deuterium-exchange labelling and two-dimensional 1H nuclear magnetic resonance (NMR). This technique may also be applied to other protein-protein interactions to identify key residues that contribute to the affinity.
Over 400 companies will be exhibiting at next week's meeting of the Federation of American Societies for Experimental Biology to be held in Anaheim, California. A new p53-deficient transgenic mouse strain and a laser-induced fluorescence detector for capillary electrophoresis will be featured.
