Latest Research

  • Letter |

    Geophysical and geological data reveal increased ice-sheet variability and surface meltwater—possibly analogous to future conditions—offshore of the Aurora subglacial basin of East Antarctica during warm climate intervals of the past 50 million years.

    • Sean P. S. Gulick
    • , Amelia E. Shevenell
    • , Aleksandr Montelli
    • , Rodrigo Fernandez
    • , Catherine Smith
    • , Sophie Warny
    • , Steven M. Bohaty
    • , Charlotte Sjunneskog
    • , Amy Leventer
    • , Bruce Frederick
    •  & Donald D. Blankenship
  • Article |

    In vivo deuterium labelling reveals a quiescent population of long-lived human virus-specific memory CD8 T cells that maintain the epigenetic landscape of effector cells, which facilitates rapid responses to pathogen re-exposure.

    • Rama S. Akondy
    • , Mark Fitch
    • , Srilatha Edupuganti
    • , Shu Yang
    • , Haydn T. Kissick
    • , Kelvin W. Li
    • , Ben A. Youngblood
    • , Hossam A. Abdelsamed
    • , Donald J. McGuire
    • , Kristen W. Cohen
    • , Gabriela Alexe
    • , Shashi Nagar
    • , Megan M. McCausland
    • , Satish Gupta
    • , Pramila Tata
    • , W. Nicholas Haining
    • , M. Juliana McElrath
    • , David Zhang
    • , Bin Hu
    • , William J. Greenleaf
    • , Jorg J. Goronzy
    • , Mark J. Mulligan
    • , Marc Hellerstein
    •  & Rafi Ahmed
  • Letter |

    Computationally designed icosahedral protein-based assemblies can protect their genetic material and evolve in biochemical environments, suggesting a route to the custom design of synthetic nanomaterials for non-viral drug delivery.

    • Gabriel L. Butterfield
    • , Marc J. Lajoie
    • , Heather H. Gustafson
    • , Drew L. Sellers
    • , Una Nattermann
    • , Daniel Ellis
    • , Jacob B. Bale
    • , Sharon Ke
    • , Garreck H. Lenz
    • , Angelica Yehdego
    • , Rashmi Ravichandran
    • , Suzie H. Pun
    • , Neil P. King
    •  & David Baker
  • Letter |

    Electron cryo-microscopy density maps of mouse TMEM16A reconstituted in nanodiscs or solubilized in detergent reveal two functional states of calcium-activated chloride channels.

    • Shangyu Dang
    • , Shengjie Feng
    • , Jason Tien
    • , Christian J. Peters
    • , David Bulkley
    • , Marco Lolicato
    • , Jianhua Zhao
    • , Kathrin Zuberbühler
    • , Wenlei Ye
    • , Lijun Qi
    • , Tingxu Chen
    • , Charles S. Craik
    • , Yuh Nung Jan
    • , Daniel L. Minor Jr
    • , Yifan Cheng
    •  & Lily Yeh Jan
  • Article |

    In bilaterian animals, the final configurations of central nervous systems seem unrelated to neuroectodermal patterning systems, so it is likely that the various architectures of the ventral nerve cords evolved convergently, many times.

    • José M. Martín-Durán
    • , Kevin Pang
    • , Aina Børve
    • , Henrike Semmler Lê
    • , Anlaug Furu
    • , Johanna Taylor Cannon
    • , Ulf Jondelius
    •  & Andreas Hejnol
  • Letter |

    DNA methylation profiling of virus-specific T cells during acute viral infection in mice provides evidence that a fate-permissive subset of effector CD8 T cells dedifferentiates into long-lived memory T cells.

    • Ben Youngblood
    • , J. Scott Hale
    • , Haydn T. Kissick
    • , Eunseon Ahn
    • , Xiaojin Xu
    • , Andreas Wieland
    • , Koichi Araki
    • , Erin E. West
    • , Hazem E. Ghoneim
    • , Yiping Fan
    • , Pranay Dogra
    • , Carl W. Davis
    • , Bogumila T. Konieczny
    • , Rustom Antia
    • , Xiaodong Cheng
    •  & Rafi Ahmed
  • Letter |

    ‘Coincidence-detecting’ phosphoinositide sensors are used to study changes in the phosphoinositide lipid species found in membranes during the development and maturation of endocytic clathrin-coated vesicles.

    • Kangmin He
    • , Robert Marsland III
    • , Srigokul Upadhyayula
    • , Eli Song
    • , Song Dang
    • , Benjamin R. Capraro
    • , Weiming Wang
    • , Wesley Skillern
    • , Raphael Gaudin
    • , Minghe Ma
    •  & Tom Kirchhausen

Latest Reviews & Analysis

  • News and Views |

    Have the molecular mechanisms that are linked to the developmental organization of centralized nervous systems evolved once or multiple times? Evidence from nine animal species points to the latter.

    • Caroline B. Albertin
    •  & Clifton W. Ragsdale
  • News and Views |

    A geological record reveals that the Aurora sector of the Antarctic Ice Sheet showed contrasting responses to past periods of atmospheric warmth. The findings might help to predict the ice sheet’s response to modern warming.

    • Sarah Greenwood
  • News and Views |

    Memory T cells protect against previously encountered pathogens, but their origins are unclear. Two studies track DNA modifications over time and find that these cells arise from effector T cells.

    • Kyla D. Omilusik
    •  & Ananda W. Goldrath
  • News and Views |

    Dense stellar remnants called white dwarfs are often found in binary star systems. Satellite observations suggest a previously unknown way in which a white dwarf can draw material from its companion star.

    • Thomas Marsh
  • News and Views |

    In multiple sclerosis, the blood-coagulation factor fibrinogen can enter the brain. It emerges that fibrinogen inhibits the maturation of cells called oligodendrocytes that repair nerve-fibre insulation and maintain neuronal communication.

    • Klaus-Armin Nave
    •  & Hannelore Ehrenreich
  • News and Views |

    DNA can be designed to self-assemble into target shapes, but the size and quantity of objects that can be prepared have been limited. Methods to overcome these problems have now been found.

    • Fei Zhang
    •  & Hao Yan

News & Comment

Outlook

Energy transitions

Sébastien Thibault

Energy transitions

Fossil fuels are on the way out, but slowly. Their exit has massive ramifications for many sectors and is causing ripples in both politics and society.

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