Abstract
SYNTHESIS of the α and β-chains for haemoglobin is dictated by independent genetic loci. The first evidence for this notion came from Smith and Torbert's observation that inheritance of haemoglobin Hopkins-2 (Ho-2) was independent from that of haemoglobin S1, and that Ho-2 was an α-chain variant2. We wish to report the amino-acid replacements involved. These structural changes establish the presence of at least two α-chain genes in man. Some physical and physiological properties of the abnormal haemoglobin, and the clinical status of carriers, have been reported in another article3.
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OSTERTAG, W., VON EHRENSTEIN, G. & CHARACHE, S. Duplicated α-Chain Genes in Hopkins-2 Haemoglobin of Man and Evidence for Unequal Crossing Over between Them. Nature New Biology 237, 90–94 (1972). https://doi.org/10.1038/newbio237090a0
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DOI: https://doi.org/10.1038/newbio237090a0
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