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Duplicated α-Chain Genes in Hopkins-2 Haemoglobin of Man and Evidence for Unequal Crossing Over between Them

Nature New Biology volume 237, pages 90–94 (1972)Cite this article

Abstract

SYNTHESIS of the α and β-chains for haemoglobin is dictated by independent genetic loci. The first evidence for this notion came from Smith and Torbert's observation that inheritance of haemoglobin Hopkins-2 (Ho-2) was independent from that of haemoglobin S1, and that Ho-2 was an α-chain variant2. We wish to report the amino-acid replacements involved. These structural changes establish the presence of at least two α-chain genes in man. Some physical and physiological properties of the abnormal haemoglobin, and the clinical status of carriers, have been reported in another article3.

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References

  1. Smith, E. W., and Torbert, J. V., Bull. Johns Hopkins Hosp., 102, 38 (1958).

    CAS  PubMed  Google Scholar 

  2. Bradley, jun., T. B., Boyer, S. H., and Allen, jun., F. H., Bull. Johns Hopkins Hosp., 108, 75 (1961).

    Google Scholar 

  3. Charache, S., Ostertag, W., and von Ehrenstein, G., Nature New Biology., 234, 248 (1971).

    Article  CAS  Google Scholar 

  4. Charache, S., Weatherall, D. J., and Clegg, J. B., J. Clin. Invest., 45, 813 (1966).

    Article  CAS  Google Scholar 

  5. Huisman, Titus H. J., and Dozy, Andree M., J. Chromatog., 19, 160 (1965).

    Article  CAS  Google Scholar 

  6. Clegg, J. B., Naughton, M. A., and Weatherall, D. J., J. Mol. Biol., 19, 91 (1966).

    Article  CAS  Google Scholar 

  7. Jones, R. T., Cold Spring Harbor Symp. Quant. Biol., 29, 297 (1964).

    Article  CAS  Google Scholar 

  8. Weisblum, B. F., Gonano, F., von Ehrenstein, G., and Benzer, S., Proc. US Nat. Acad. Sci., 53, 328 (1965).

    Article  CAS  Google Scholar 

  9. Hanson, H., Glasser, D., and Kirschke, H., Z. Physiol. Chem., 340, 107 (1965).

    Article  CAS  Google Scholar 

  10. von Ehrenstein, G., Cold Spring Harbor Symp. Quant. Biol., 31, 705 (1966).

    Article  CAS  Google Scholar 

  11. Lehmann, H., and Carrell, R. W., Brit. Med. J., 4, 748 (1968).

    Article  CAS  Google Scholar 

  12. Abramson, R. K., Rucknagel, D. L., Shreffler, D. C., and Saave, J. J., Science, 169, 194 (1970).

    Article  CAS  Google Scholar 

  13. Boyer, S. H., Noyes, A. N., Vroblik, G. R., Donaldson, L. J., Schaefer, E. W., Gray, C. W., and Thurman, T. F., Science, 171, 182 (1970).

    Article  Google Scholar 

  14. Schroeder, W. A., Huisman, T. H. J., Shelton, J. R., Shelton, J. B., Kleihauer, E. F., Dozy, A. M., and Robberson, B., Proc. US Nat. Acad. Sci., 60, 537 (1968).

    Article  CAS  Google Scholar 

  15. Baglioni, C., Proc. US Nat. Acad. Sci., 48, 1880 (1962).

    Article  CAS  Google Scholar 

  16. Barnabas, J., and Muller, C. J., Nature, 194, 931 (1962).

    Article  CAS  Google Scholar 

  17. Ostertag, W., and Smith, E. W., Europ. J. Biochem., 10, 371 (1969).

    Article  CAS  Google Scholar 

  18. Brimhall, B., Hollan, S., Jones, R. T., Koler, R. D., Stockten, Z., and Szelenyi, J. G., Clin. Res., 18, 184 (1970).

    Google Scholar 

  19. Hollan, S. R., Szelenyi, J. G., Brimhall, B., Duerst, M., Jones, R. T., Koler, R. D., and Stocklen, Z., Nature, 235, 47 (1972).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Max Planck Institute for Experimental Medicine, Göttingen

    W. OSTERTAG & G. VON EHRENSTEIN

  2. Hematology Division, Johns Hopkins University, School of Medicine, Baltimore, Maryland

    S. CHARACHE

Authors
  1. W. OSTERTAG
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  2. G. VON EHRENSTEIN
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  3. S. CHARACHE
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OSTERTAG, W., VON EHRENSTEIN, G. & CHARACHE, S. Duplicated α-Chain Genes in Hopkins-2 Haemoglobin of Man and Evidence for Unequal Crossing Over between Them. Nature New Biology 237, 90–94 (1972). https://doi.org/10.1038/newbio237090a0

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