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Carcinogen Dimethylnitrosamine produced in vivo from Nitrite and Aminopyrine

Nature New Biology volume 236, pages 177–178 (1972)Cite this article

Abstract

IN experimental conditions, nitrite can interact with secondary amines in the rodent stomach at mildly acid pH to form nitrosamines1–4, a large number of which are potent carcinogens5. As tertiary amines also react in this way6, we have examined the analgesic aminopyrine, 4-dimethylaminoantipyrine (pyramidon), as being representative of many commonly used tertiary amine drugs.

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Author information

Author notes

  1. W. LIJINSKY

    Present address: Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, 37830

  2. M. GREENBLATT

    Present address: National Cancer Research Laboratories, University of Otago Medical School, Dunedin, New Zealand

Authors and Affiliations

  1. Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, Nebraska, 68105

    W. LIJINSKY & M. GREENBLATT

  2. Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, 37830

    M. GREENBLATT

Authors
  1. W. LIJINSKY
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  2. M. GREENBLATT
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LIJINSKY, W., GREENBLATT, M. Carcinogen Dimethylnitrosamine produced in vivo from Nitrite and Aminopyrine. Nature New Biology 236, 177–178 (1972). https://doi.org/10.1038/newbio236177a0

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  • DOI: https://doi.org/10.1038/newbio236177a0

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