Admixture mapping of severe asthma exacerbations in Hispanic/Latino children and youth

Journal:
Thorax
Published:
DOI:
10.1136/thorax-2022-218755
Affiliations:
33
Authors:
36
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Research Highlight

Indigenous American ancestry linked to severe asthma attacks

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Mexican Americans and Puerto Ricans with Indigenous American ancestry have a significantly higher risk of severe asthma attacks, which can be traced to several specific genetic variants.

Both the prevalence of asthma and of severe asthma exacerbations in the United States vary substantially according to ethnicity.

Now, a team led by researchers from University of La Laguna has used whole-genome sequencing to identify genetic variants associated with severe asthma in 1,124 Puerto Rican and 625 Mexican American children with asthma. They then examined associations with ancestry.

They found one genetic variant linked to severe asthma exacerbations and Indigenous American ancestry in Mexican Americans, and two in Puerto Ricans, as well as a new genetic mutation associated with severe asthma attacks in people of Hispanic/Latino ethnicity.

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References

  1. Thorax 78, 220–221 (2023). doi: 10.1136/thorax-2022-218755
Institutions Authors Share
University of California, San Francisco (UCSF), United States of America (USA)
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 0.14
University of La Laguna (ULL), Spain
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 0.13
University Hospital of the Canary Islands, ULL, Spain
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 0.11
Biomedical Research Networking Centers (CIBER), Spain
3.666667
 0.10
Donostia University Hospital, Spain
2.000000
 0.06
National University of Singapore (NUS), Singapore
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 0.06
University of Minnesota (UMN), United States of America (USA)
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 0.03
Henry Ford Health System (HFHS), United States of America (USA)
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 0.03
Health Center San Agustín, Spain
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 0.03
The City University of New York (CUNY), United States of America (USA)
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 0.03
Hospital Universitario Fundación Jiménez Díaz (FJD), UAM, Spain
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 0.03
August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Spain
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Pediatric Pulmonology Clinics, United States of America (USA)
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University of the Basque Country (UPV/EHU), Spain
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 0.03
Biomedical Research Networking Center for Epidemiology and Public Health (CIBERESP), Spain
0.833333
 0.02
Barcelona Institute for Global Health (ISGlobal), Spain
0.833333
 0.02
Pompeu Fabra University (UPF), Spain
0.833333
 0.02
Hospital Universitario de Gran Canaria Doctor Negrín, Spain
0.500000
 0.01
Joint Research Unit of Epidemiology and Environmental Health, Spain
0.500000
 0.01
Hospital General de La Palma, Spain
0.500000
 0.01
University Hospital of Nuestra Señora de Candelaria, Spain
0.500000
 0.01
Vall d'Hebron University Hospital (HUVH), ICS, Spain
0.500000
 0.01
Autonomous University of Barcelona (UAB), Spain
0.333333
 0.01
Sachs’ Children’s Hospital, Sweden
0.333333
 0.01
Karolinska Institute (KI), Sweden
0.333333
 0.01
Stockholm South General Hospital, Sweden
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 0.01
Germans Trias i Pujol University Hospital (HUGTP), ICS, Spain
0.333333
 0.01