Blood monocyte-derived CD169+ macrophages contribute to antitumor immunity against glioblastoma
- Journal:
- Nature Communications
- Published:
- DOI:
- 10.1038/s41467-022-34001-5
- Affiliations:
- 1
- Authors:
- 6
Research Highlight
White blood cells that fight against brain tumours
© DR P. MARAZZI/SCIENCE PHOTO LIBRARY/Getty Images
A type of white blood cell that aids the fight against aggressive brain tumours has been identified.
Glioblastomas are the most aggressive kind of brain tumours, with only about one in ten patients surviving beyond five years.
Therapies that help the immune system to fight cancers are a promising form of treatment. But such immunotherapies are hampered by white-blood cells known as macrophages enmeshed in glioblastomas.
Not all macrophages associated with tumours are bad — some actually suppress tumours. But it has been difficult to distinguish between tumour-supporting and tumour-suppressing macrophages.
Now, six researchers from the Korea Advanced Institute of Science and Technology (KAIST) in South Korea have found that a certain group of macrophages in glioblastomas promote an immune response against tumours.
Therapies that aid this group of macrophages could thus give the immune system a helping hand against glioblastomas.
References
- Nature Communications 13, 6211 (2022). doi: 10.1038/s41467-022-34001-5
| Institutions | Authors | Share |
|---|---|---|
| Korea Advanced Institute of Science and Technology (KAIST), South Korea | 1.00 |