Biochemical Gas Sensors (Biosniffers) Using Forward and Reverse Reactions of Secondary Alcohol Dehydrogenase for Breath Isopropanol and Acetone as Potential Volatile Biomarkers of Diabetes Mellitus
- Journal:
- Analytical Chemistry
- Published:
- DOI:
- 10.1021/acs.analchem.7b03191
- Affiliations:
- 9
- Authors:
- 14
Research Highlight
Electronic sniffers can detect diabetes on the breath
© Julian Ward/Moment/Getty
An
electronic ‘nose’ can pick up the scent of diabetes on human breath, according
to a paper published in Analytical
Chemistry.
A
team of researchers, led by scientists from the Tokyo
Medical and Dental University, have developed ‘biosniffers’ that are able to
detect traces of two chemicals in human breath, acetone and isopropanol, that
are linked to type 1 and type 2 diabetes.
Testing the biosniffers on 55
healthy volunteers, and 25 individuals with either type 2 or type 1 diabetes,
they found the devices could detect much higher levels of acetone in the breath
of the individuals with diabetes compared to non-diabetic participants. It also
found higher levels of isopropanol in people with type 2, but not type 1,
diabetes.
The authors said that the
biosniffers could offer a non-invasive diagnostic tool for diabetes and other
diseases.
References
- Analytical Chemistry 89, 12261−12268 (2018). doi: 10.1021/acs.analchem.7b03191
Institutions | Authors | Share |
---|---|---|
Tokyo Medical and Dental University (TMDU), Japan | 0.94 | |
Kansai University, Japan | 0.04 | |
Kyushu University, Japan | 0.02 |