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Strong non-covalent interactions enable the formation of rotaxanes that seek out cellular targets and fluoresce on binding them. See Schreiber & Smith [https://www.nature.com/articles/s41570-019-0095-1]
Thermal denaturation of proteins affords species that differ in terms of cofactors and conformations. Ion mobility spectrometry and mass spectrometry can be used to unravel these mixtures and learn the factors stabilizing certain protein forms.
All organisms have developed vital sensory processes that enable prompt reactions in response to external environmental changes. Su and co-workers propose a bioinspired thermoresponsive device made of solid-state nanochannels that induce thermally selective ion transport.
The development of C–H functionalization methodology offers a new logic for chemical synthesis. Dirhodium tetracarboxylates have emerged as some of the most effective catalysts for these transformations, enabling site-selective and stereoselective insertion of transient metal carbenes into C–H bonds.
FoF1-ATPase is a vital molecular machine in organisms responsible for the catalytic synthesis of the basic energy unit ATP. In this Review, the development of FoF1-ATPase reconstitution into artificial architectures is discussed ultimately leading to the development of stimuli-responsive ATP synthesis.
Light emitting, molecularly tunable organic colour-centers are sp3 quantum defects that create localized two-level systems within the host crystals, providing unique tools to harness electrons, excitons, phonons and spin for novel functionality.
The selective conjugation of two or more molecules is readily achieved using covalent click chemistry or non-covalent click chemistry. The latter approach makes use of complementary molecular recognition partners, and its speed and reversibility are advantageous for many biological applications.