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Volume 3 Issue 6, June 2019

Strong non-covalent interactions enable the formation of rotaxanes that seek out cellular targets and fluoresce on binding them. See Schreiber & Smith [https://www.nature.com/articles/s41570-019-0095-1]

Concept: Bradley D. Smith / Design: Carl Conway

Research Highlights

  • Thermal denaturation of proteins affords species that differ in terms of cofactors and conformations. Ion mobility spectrometry and mass spectrometry can be used to unravel these mixtures and learn the factors stabilizing certain protein forms.

    • David Schilter
    Research Highlight

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  • A potential new source of hydroxyl radicals – that mediate the reactions of organic aerosols in the atmosphere – has been identified.

    • Claire Ashworth
    Research Highlight
  • All organisms have developed vital sensory processes that enable prompt reactions in response to external environmental changes. Su and co-workers propose a bioinspired thermoresponsive device made of solid-state nanochannels that induce thermally selective ion transport.

    • Gabriella Graziano
    Research Highlight
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Reviews

  • FoF1-ATPase is a vital molecular machine in organisms responsible for the catalytic synthesis of the basic energy unit ATP. In this Review, the development of FoF1-ATPase reconstitution into artificial architectures is discussed ultimately leading to the development of stimuli-responsive ATP synthesis.

    • Yi Jia
    • Junbai Li
    Review Article
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Perspectives

  • The selective conjugation of two or more molecules is readily achieved using covalent click chemistry or non-covalent click chemistry. The latter approach makes use of complementary molecular recognition partners, and its speed and reversibility are advantageous for many biological applications.

    • Cynthia L. Schreiber
    • Bradley D. Smith
    Perspective
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