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Fluorescent amino acids are widely used as building blocks for non-perturbative labelling of peptides and proteins. This Review covers recent advances in the design and synthesis of fluorescent amino acids with bespoke optical properties for different applications in biological studies.
Helices have unique properties, exploited by nature in critical functional roles. This Review gives an overview of the application of synthetic helical polymers in biology and medicine, highlighting examples where the role of the helical conformation has been critical.
Properties of nanomaterials respond to changes in the material’s phase, as well as changes in size, composition and morphology. This Review discusses the most recent developments in phase engineering of nanomaterials to afford conventional and unconventional crystal phases, amorphous phases and amorphous–crystalline heterophases.
This Review highlights bacteria as biological factories in diverse applications, with an emphasis on targeted genetic engineering for the production of bioactive natural products.
During free-radical polymerization of multivinyl monomers, the regulation of intermolecular crosslinking and intramolecular cyclization enables the construction of complex polymer architectures. This Review summarizes methods to achieve this control and techniques to analyse the sub-chain connections. Finally, it discusses exemplary biomedical applications of the complex polymer products.
Sialic acids are a heterogeneous group of monosaccharides that play key roles in human glycobiology. This Review describes derivatization strategies that allow the straightforward analysis of sialic acid linkage isomers by mass spectrometry and exemplifies their use for biological samples.
Microorganisms enzymatically degrade natural polymers and synthetic plastics to enable a sustainable environment. This Review describes common features of these enzymes and how they can be harnessed to convert waste into useful precursors.
In this Review, the authors describe single-cell protein analysis technologies and assess their advantages and limitations. The emerging technologies presented have the potential to reveal new insights into tumour heterogeneity and therapeutic resistance, elucidate mechanisms of immune response and immunotherapy, and accelerate drug discovery.
Organic materials can serve as sustainable electrodes in lithium batteries. This Review describes the desirable characteristics of organic electrodes and the corresponding batteries and how we should evaluate them in terms of performance, cost and sustainability.
Macrocyclic peptides have great potential in drug discovery because they occupy unique chemical space between small molecules and biologics and could, thus, be useful against previously undruggable targets. This Review describes the methods for generating libraries of genetically encoded cyclic peptides and highlights how each is suited to different screening approaches.
The water-gas shift reaction converts CO and H2O into H2 and CO2, and reactive separation of the latter optimizes H2 production. This Review describes how alkaline Ca and Mg compounds trap CO2 to afford carbonates as part of carbon mineralization.
Many present and emerging electronic devices make use of organic semiconductors in view of their readily tuneable molecular and electronic structures. This Review describes the importance of analytical and computational tools in studying the molecules as well as their hierarchical self-assemblies, in which the motion of charges and excited states govern device properties.
