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  • JWST collects vast amounts of information about exoplanets light years away from Earth. Back home, the measured optical constants of laboratory aerosols are critically input parameters in models to interpret the observational results.

    • Ella Sciamma-O’Brien
    • Thomas Drant
    • Nicholas Wogan
    News & Views
  • Semiconducting polymers require narrow molecular weight distributions for optimal efficiency. Synthesizing such polymers is no easy task, however a combined ultrasonication-assisted Stille polymerization reaction could be the solution to this problem.

    • Alexander Rosu-Finsen
    Research Highlight
  • A metal templating approach can be used to generate homo- and heterointerlocked cage structures.

    • Stephanie Greed
    Research Highlight
  • Gold catalysts have attracted attention for their ability to activate hydrogen towards the hydrogenation of organic molecules. This Review explores strategies to enhance hydrogen–gold interactions to help design new efficient hydrogenation catalysts.

    • Nikolaos Dimitratos
    • Gianvito Vilé
    • Robert Wojcieszak
    Review Article
  • Electrochemical devices enable clean energy technologies such as hydrogen cells, batteries and solar fuels. Their design is hindered by incomplete information about the electrochemical interface during operation. Complementary optoelectronic probes offer a path to improved mechanistic insights into such interfaces.

    • Ernest Pastor
    • Zan Lian
    • F. Pelayo García de Arquer
    Review Article
  • The unique properties of selenium have been exploited in protein science. This Review highlights the recent applications of selenium chemistry in protein chemical synthesis, modification, folding, stabilization, the preparation of therapeutic proteins and more.

    • Zhenguang Zhao
    • Shay Laps
    • Norman Metanis
    Review Article
  • Chemistry education research is a well-established field that has the potential to inform chemistry teaching at all levels. But to the uninitiated, much of the work can seem descriptive while quantitative studies often suffer from a lack of reproducibility. Here I delve into these characteristics and explain why this should not deter chemistry teachers from engaging.

    • Keith S. Taber
    In the Classroom
  • DNA has emerged as an attractive substrate for molecular information processing. This Review explores the application of DNA for computing and data storage, as well as the route to integrate these fields.

    • Shuo Yang
    • Bas W. A. Bögels
    • Tom F. A. de Greef
    Review Article
  • This Review introduces solar reforming as an emerging technology to produce sustainable fuels and chemicals from diverse waste feedstocks using sunlight. The chemistry and concept of solar reforming, suggestions of key metrics and proposed directions to realize solar-powered refineries for a future circular economy are discussed.

    • Subhajit Bhattacharjee
    • Stuart Linley
    • Erwin Reisner
    Review Article
  • Providing a stable and reliable supply of electrons is crucial for the future of quantum computing processors. Here, electron withdrawing groups are added to species which improve the flow of electrons.

    • Alexander Rosu-Finsen
    Research Highlight
  • This Review highlights the strategies and challenges for targeting RNA with small molecules in medicinal chemistry. It emphasizes their potential as drugs and tools for understanding complex biological processes while encouraging chemists to contribute to this field for future advances.

    • Sandra Kovachka
    • Marc Panosetti
    • Maria Duca
    Review Article
  • Performing logical operations with molecular excitons may provide opportunities for developing ultrafast, subnanometre and biocompatible computational architectures. This Roadmap outlines a framework for using multiexcitonic processes such as singlet fission and triplet–triplet annihilation to drive logical devices.

    • Rohan J. Hudson
    • Thomas S. C. MacDonald
    • Dane R. McCamey
    Roadmap
  • The reduction of molecular species containing arene to alkali metal cation interactions with other alkali metals has been found to contradict the expectation provided by simple considerations of relative reduction potentials.

    • Johannes Kreutzer
    Research Highlight
  • By drawing inspiration from ion transport in biology, researchers have developed highly selective channels for the separation and enrichment of Li+ ions from complex aqueous solutions.

    • Stephanie Greed
    Research Highlight
  • The European BorderSens project leverages voltammetric sensors, developed with end-users’ input, to rapidly and accurately detect illicit drugs. By embracing practicalities and validation, this technology has the potential to combat the illicit drug problem.

    • Robin Van Echelpoel
    • Karolien De Wael
    Down to Business
  • Lytic polysaccharide monooxygenases are key enzymes in biomass processing and pathogenicity. They are, to our knowledge, the first known copper enzymes capable of utilizing H2O2 to hydroxylate C–H bonds. This Review draws a portrait of the catalytic paths at play and highlights outstanding questions in their reactivity.

    • Alessia Munzone
    • Vincent G. H. Eijsink
    • Bastien Bissaro
    Review Article
  • Thirty-four years ago, Curry and Rumelhart described a neural network-based approach to annotate tandem mass spectra. Their ideas foreshadowed several important developments in computational mass spectrometry over the past decade, but many of the challenges they discuss remain relevant today.

    • Michael A. Skinnider
    News & Views
  • A route to synthetically interesting axially chiral diaryl ethers combines an asymmetric desymmetrization and a kinetic resolution.

    • Stephen G. Davey
    Research Highlight
  • Cable bacteria are able to conduct electrons to interconvert oxygen and water. Here, researchers have isolated the conducting cable bacteria skeletons to demonstrate their activity in an electrochemical cell.

    • Stephanie Greed
    Research Highlight