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An article in Nature Biotechnology reports an expansion microscopy technique that does not require a separate anchoring step, achieving a resolution comparable to super-resolution imaging techniques.
Metabolomics is on the precipice of transforming from a research tool into a powerful clinical platform to improve precision medicine. However, metabolomics methods need to be validated in clinical research to enable rapid translation of research results into clinical tests.
A paper in Science Robotics reports living microrobots made of magnetically responsive bacteria for targeted drug delivery in cancer therapy. A magnetic torque-driven control scheme enhances the transport of the microrobots through the endothelial barrier to the tumour site.
A paper in Nature Materials reports an effective and safe polymeric nanoparticle for the functional delivery of RNA into the lungs of various animal species.
Welcome to the very first issue of Nature Reviews Bioengineering, a new Nature Reviews journal covering all areas of bioengineering, with a particular focus on translation, inclusivity and accessibility.
The Gx Sweat Patch is a wearable microfluidic sweat sensor that can be worn by athletes to monitor their sweating rate and sweat chloride concentration. Here, we highlight the commercialization of the Gx Sweat Patch, from developing and optimizing prototypes of a wearable sweat-sensing platform, to validation in competitive individual and team-sport athletes, and the challenges of commercial launch.
Engineers need to meaningfully engage in global health by developing solutions that work in the low-resource environments that are a reality for many health-care professionals and patients around the world. Engineering World Health, founded in 2001, aims to inspire, educate and empower the biomedical engineering community to improve health-care delivery around the world.
Bioengineering has the power to improve health globally by engineering diagnostic, treatment and disease monitoring platforms that function in diverse settings, including resource-constrained contexts. In this Viewpoint, the authors highlight the pressing challenges that need to be addressed to make the field more equitable and to enable bioengineered solutions that can be implemented anywhere, anytime and by anyone.
Synthetic morphogenesis is limited by knowledge gaps about the competencies of cells and cell groups. This Review discusses a synthetic bioengineering framework based on empirically determined properties of cells, including goal-seeking and agential behaviours, which will allow the creation of complex devices that cannot be built using bottom-up approaches.
The feasibility of large-scale testing with lateral flow tests has been demonstrated in the COVID-19 pandemic. This Review examines lessons learned from the COVID-19 pandemic to inform the design and bioengineering of next-generation lateral flow tests to strengthen future diagnostic resilience.
Luminescence imaging in the near-infrared (NIR) region enables non-radiative, fast-feedback, low-cost and high-contrast in vivo imaging of biological tissues. This Review discusses engineering challenges that need to be addressed to enable clinical translation of NIR luminescence imaging.
Adult stem cell-derived organoids closely resemble their tissue of origin. This Review discusses recent developments in CRISPR-mediated genome engineering and its application using adult-stem-cell-derived organoids in the construction of isogenic disease models and for clinical gene repair.
