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This Review discusses the role of mitophagy in cellular and organismal health and disease, with a specific focus on human ageing and evidence obtained in clinical studies.
This Review article discusses how the emerging field of metabolomic epidemiology gives insight into the aetiology of various diseases and how these findings could be translated into clinical applications.
Mishra and Townsend present an overview of the regulation, function and plasticity of adipose tissue sensory nerves that are relevant for metabolic processes in health and disease.
In this Review, TeSlaa, Ralser, Fan and Rabinowitz comprehensively review the fundamental biochemical aspects of the pentose phosphate pathway and discuss its biological relevance in the context of physiology and pathology.
Kim and colleagues discuss the regulatory mechanisms of lipogenesis, the physiological and pathological role of lipogenesis in tissues such as adipose tissue, liver, neurons and cancer, and how lipogenesis may be targeted therapeutically to ameliorate disease.
Matsumura, Wei and Sakai discuss epitranscriptomic modifications and their links to metabolic disease, how genetic and environmental factors influence epitranscriptomics, and how the epitranscriptome is linked to the epigenome.
