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Rosenbaum and Foster discuss the metabolic underpinnings of weight loss and weight loss maintenance, as well as the implications of considering them as distinct metabolic states for the treatment of obesity.
Lynch and colleagues give an overview of the classical roles of the cytokine IL-17 in host immunity, and look deeper into the emerging roles of IL-17 in cross-talk between the nervous system and gut and how IL-17 regulates and is regulated by systemic metabolic processes.
Cook and colleagues discuss the nature of hepatic insulin resistance and argue that liver hyperinsulinization (excessive hepatic insulin action) is a driver of hepatic steatosis.
This Perspective provides a concise overview of the diverse functions of vitamin K in physiology and metabolism, including its recently discovered role in ferroptosis.
The authors of this Perspective argue that the commonly used terms ‘mitochondrial function’ and ‘mitochondrial dysfunction’ do not do justice to the diverse mitochondrial features, activities, functions and behaviours within cells, and thus call for the field to adopt more specific terminology in the context of mitochondrial biology.
The authors provide an overview of the current and emerging wearable and digital devices that can inform about specific metabolic outcomes in people, discussing how they could be used to create more tailored preventive and therapeutic strategies against cardiometabolic disease.
Nicholls and Brand present a bioenergetic critique of the futile creatine cycle as a mechanism for UCP1-independent diet-induced thermogenesis in brown adipose tissue.