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ARID1A/B loss causes oncogenic BAF complex redistribution. Zhu and colleagues show that concomitant ARID1A and ARID1B loss results in carcinogenesis and disruptive redistribution of residual cBAF subcomplexes, impairing pBAF function.
Erez and colleagues demonstrate that increased expression of arginosuccinate synthase under glucose deprivation leads to gluconeogenesis and increased purine synthesis, which when targeted can enhance response to immune checkpoint blockade.
Zhang and colleagues analyzed data from patient samples exposed to the BCL2 inhibitor venetoclax, approved for treatment of acute myeloid leukemia, identifying modes of therapy resistance and synthetic lethality with MCL1 inhibition.
Irvine and colleagues present a lipid nanoparticle platform containing self-replicating interleukin-12 RNA, which showed therapeutic efficacy in vivo by promoting immunogenic cell death and priming CD8+ T cells.
Siu and colleagues use a bespoke ctDNA assay and show predictive utility of longitudinal ctDNA analysis in a phase II clinical trial of patients receiving pembrolizumab that included multiple solid tumor types.
Rugge and colleagues report that patients with cancer, particularly those who are older and male, face a significantly increased risk of adverse outcomes of SARS-CoV-2 infection.
Two papers by Kather and colleagues and Gerstung and colleagues develop workflows to predict a wide range of molecular alterations from pan-cancer digital pathology slides.
Two papers by Kather and colleagues and Gerstung and colleagues develop workflows to predict a wide range of molecular alterations from pan-cancer digital pathology slides.
Charron and colleagues describe a form of Sonic hedgehog–induced replicative stress through Cdc7-dependent origin firing that contributes to medulloblastoma tumorigenesis.
Zhong and colleagues find that the deubiquitinase USP25 acts as a critical regulator of colorectal cancer by modulating intestinal inflammation and the gut microbiota.
Yin and colleagues show that hepatic aldolase B suppresses hepatocellular carcinoma by controlling tumor metabolic reprogramming through G6PD inhibition.
Scherz-Shouval and colleagues characterize the dynamic changes in cancer-associated fibroblast subpopulations during breast cancer progression. They find that the ratio of S100A4+ and PDPN+ CAF subsets is associated with clinical outcome.
Jobin and colleagues show that targeting inflammation with TNF therapy has a preventative effect on carcinogenic activity of the microbiota in mouse models of colitis-associated colorectal cancer.
Mellman and colleagues show that dendritic cells represent a key source of PD-L1 in the tumor microenvironment, thereby restricting tumor infiltration by CD8+ T cells and antitumor responses.
Parsa et al. report a mechanism of lymphoma initiation involving cooperation of BCL2 and increased activity of the metabolic enzyme SHMT2, which imparts changes in DNA and histone methylation.
Alkallas et al. uncover new significantly mutated genes in a large cohort of cutaneous melanoma, including the RNA helicase DDX3X, through integrated analysis of genomic, transcriptomic and DNA methylation data.
Van Loo and colleagues report that loss of the Zeb2 regulator of epithelial-to-mesenchymal transition from the intestinal epithelium leads to inflammation, increased intestinal permeability and colorectal cancer development, which is enhanced by the resident intestinal microbiome.
A druggable genome CRISPR-Cas9 screen followed by functional validation in preclinical lung cancer models uncovers Slc33a1 as a Keap1-mutant-specific targetable dependency.
Zhang and colleagues report that multicellular clusters of circulating tumor cells are more resistant to killing by natural killer (NK) cells through altered NK ligand expression, resulting in polyclonal metastases.
Gui et al. report that tumor-cell-derived factors induce p38a activation in lung fibroblasts, leading to inactivation of type I interferon signaling, matrix remodeling and neutrophil infiltration, thereby generating a metastasis-permissive niche.