Volume 6 Issue 1, January 2022

Flagellated bacteria coated with antigen-adsorbing nanoparticles and injected into irradiated tumours elicit systemic antitumour immune responses by transporting tumour antigens towards the tumour periphery, where they are taken up by functional antigen-presenting cells.

Coating mesenchymal stromal cells with a soft gel incorporating specific chemomechanical cues that enhance the production of collagenases enhances the ability of the cells to inhibit aberrant tissue remodelling in mice with fibrotic lungs.

Injectable biomaterial vaccines designed to magnetically capture pathogen-associated molecular patterns protect mice and pigs against septic shock from lethal bacterial infections.

Efficacious cancer vaccines can be made via the cryogenic silicification of tumour cells followed by the decoration of the silicified surface with pathogen-associated molecular patterns.

Antitumour immune responses to checkpoint blockade can be augmented by modulating the microbiota in the tumour with hydrogel-embedded silver nanoparticles and specific exogenous bacteria, as shown for mice with squamous carcinoma tumours.

Flagellated bacteria coated with antigen-adsorbing polymer nanoparticles and injected into tumours in mice after radiotherapy elicit systemic antitumour effects by transporting antigens to the tumour’s periphery.

Mesenchymal stromal cells singly coated with a soft conformal gel incorporating specific chemomechanical cues inhibit aberrant tissue remodelling in mice with fibrotic lung injury.

The human proteome can be algorithmically mined to identify thousands of encrypted peptides, encoded in proteins with biological function unrelated to the immune system, that display antibacterial activity in vivo.

Two potent mitophagy inducers, identified and characterized via unsupervised machine learning and a cross-species screening approach, ameliorated the pathology of Alzheimer’s disease in worms and mice.

The tropism of engineered bacteria in vivo can be enhanced by genetic circuits, linked by AND-gate logic, that couple bacterial sensing and growth.