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A light-sheet microscope images large surgical and biopsy specimens non-destructively over large fields of view in two and three dimensions, with the same level of detail as traditional slide-based histopathology.
A library of single-strand oligonucleotide probes with a common long-adapter sequence can clone, in a single reaction, thousands of open reading frames spanning 400–5,000 bp, and has been applied to DNA from human stool and microbiome samples.
A comparison of the in vivo engraftment of scaffolds containing either an unassembled suspension of human vascular cells or an assembled network of them shows that non-inflammatory host neutrophils are indispensable mediators of vascularization.
In a rabbit model of prosthetic joint infection, optimization of the shape and loading of antibiotic clusters in a polymer implant augments and prolongs antibiotic elution while maintaining implant strength and wear rate.
An optimized formulation of glucagon-like peptide-1 recombinantly fused to an elastin-like polypeptide leads to zero-order release kinetics from a subcutaneous depot and to 10 days of glycaemic control in three mouse models of diabetes.
A simple and versatile assay that relies on the bioconjugation capabilities and ultrafast and localized deposition of polydopamine can be plugged into common laboratory bioassays to improve their detection sensitivity by orders of magnitude.
3D-printed grafts with geometrically designed and endothelialized vasculature rescue the perfusion of distal tissues in rodent models of hind limb ischaemia and myocardial infarction, preventing capillary loss, muscle atrophy and loss of function.
An array of chemically engineered CRISPR RNAs and AsCpf1 messenger RNAs leads to improvements in gene-cutting efficiency up to about 300% with respect to unmodified CRISPR RNA and plasmid-encoding AsCpf1.
A closed-loop control system measures and adjusts the concentration of a chemotherapeutic in real time and maintains it within a predefined therapeutic window in both rabbits and rats.
Ultra-broadband optoacoustic mesoscopy implemented in a handheld device enables the visualization of vascular patterns in the dermis and sub-dermis of psoriasis patients, and the quantification of inflammatory biomarkers of psoriasis.
Single-impulse photoacoustic computed tomography can, at deep penetration and high resolution and contrast, image the whole-body dynamics of small animals in real time, and track injected cancer cells and image the vasculature of whole rat brains.
An efficient and chemically defined protocol for the differentiation of human induced pluripotent stem cells into podocytes enables the recapitulation of the differential clearance of the human kidney glomerulus in an organ-on-a-chip.
An optimized nanosensor with tumour-penetrating ligands and with peptide substrates that lead to maximal tumour-specific protease cleavage detects sub-5 mm lesions in human epithelial tumour xenografts and in an orthotopic model of ovarian cancer.
Functionalized InAs quantum dots emitting in the short-wavelength infrared spectral region enable functional biomedical imaging at unprecedentedly high spatial resolution, deep penetration and fast acquisition speeds.
Nanoscale extracellular vesicles can be efficiently isolated in about 15 minutes, for downstream analyses of nucleic acids and proteins, via spontaneous labelling through a lipid nanoprobe and subsequent magnetic capture of the labelled vesicles.
A macromolecular near-infrared probe that successively responds to tumour acidity and hypoxia while amplifying detection sensitivity via signal propagation detects metastatic tumour nodules as small as 1 mm in mice.
A peptide-based fluorescent inhibitor of the dimerization of an oncoprotein of the Epstein–Barr virus blocks the proliferation of tumours associated with the virus in mice.
A carbon nanotube sensor enables real-time optical quantification of hybridization events of microRNA and other oligonucleotides in vivo and in whole urine and serum.
A hydrogel made of crosslinked clusters of highly branched polymers that has ultralow swelling pressure and that forms in 10 minutes despite its low polymer content functions as an artificial vitreous body for over one year without inducing adverse effects.