Image: Maayan Harel and Jerzy Szablowski. Design: Alex Wing.

Targeting specific brain circuits non-invasively

The July issue highlights the non-invasive modulation of brain circuits via focused ultrasound and virally encoded receptors engineered to be activated by a designer drug.

Latest Research

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    The combination of systemic immune checkpoint inhibition with local administration of a hydrogel containing the enzyme catalase, a radioisotope and an immunostimulatory agent promotes effective antitumour immune responses in mice models.

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  • Article |

    The combination of focused ultrasound and virally encoded receptors engineered to be activated by a designer drug enables, on intravenous administration of the drug, the non-invasive activation or inhibition of brain regions in mice, with cell-type and spatiotemporal specificity.

    • Jerzy O. Szablowski
    • , Audrey Lee-Gosselin
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News & Comment

  • News & Views |

    A technique combining focused ultrasound for opening the blood–brain barrier and virally encoded engineered G-protein-coupled receptors for promoting the expression of a gene targeting excitatory neurons enables the non-invasive stimulation of specific brain regions and cell types in mice.

    • Caroline Menard
    •  & Scott J. Russo
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    Polymer-coated gold nanoparticles carrying the CRISPR components for knocking out, in the striatum of adult mice with fragile X syndrome, a gene implied in the syndrome’s pathophysiology rescue the mice from the exaggerated repetitive behaviours characteristic of the syndrome’s phenotype.

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  • Editorial |

    Modelling diseases of the central and peripheral nervous systems and effectively treating neurological disorders via neuronal manipulation requires far better biomaterials and technology than are currently available.

  • News & Views |

    Design principles for the development of silicon biointerfaces enable the non-genetic, light-controlled modulation of intracellular Ca2+ dynamics, and of cellular excitability in vitro, in tissue slices and in mouse brains.

    • Seongjun Park
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    Biopolymer matrices can modulate the transcriptomic profiles of stem-cell-derived neurons in 3D culture to make them resemble cells in specific brain regions, developmental stages and disease conditions.

    • Carsten Werner
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    Nanoscale metal–organic frameworks carrying an immunotherapy payload and administered into tumours alongside a low dose of radiotherapy enhance local and systemic antitumour immunity in mouse models of breast cancer and colorectal cancer.

    • Wilfred Ngwa

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