Volume 15 Issue 5, May 2010

Modulation of neutrophil granulocyte adherence to brain ICAM immunoreactivity by leptin. Double immunohistochemistry for intracellular adhesion molecule (ICAM-1, green) and neutrophil granulocytes (7/4 antigen, red) is shown in the brain of lipopolysaccharide (LPS)-treated mice. The majority of 7/4-IR cells (neutrophils) were found adhering to ICAM-1-IR cells, on both the luminal and abluminal (brain) sides of vasculature-like structures suggesting an integrin-mediated neutrophil arrest to the endothelium, the essential step for eventual neutrophil infiltration into the parenchyma. For further information on this topic, including the role of leptin in modulating this process see the article by Rummel et al. on pages 523–534.