Volume 14 Issue 1, January 2009
Genetic manipulation of Corticotrophin Releasing Factor (CRF) levels within the rat amygdala leads to altered reproductive, anxiety, and depressive behaviors. Upper right shows immunohistochemistry of CRF expression in rat central amygdala following infection with a genetically modified lentivirus which expresses constitutively high levels of CRF (LV-CRF) in infected neurons. Bottom row, in vitro demonstration of CRF co-expression with green fluorescent protein (GFP) in HEK293 cells infected with LV–CRF. For more information on this topic, please refer to the article by Keen-Rhinehart et al. on pages 37–50.
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