Volume 13 Issue 11, November 2008

The cover depicts high resolution 18-fluoro-deoxyglucose positron emission tomography images of rhesus monkey brain demonstrating an interaction between the type of stress a monkey is exposed to and its genetic makeup (short (s) vs long (l) allele polymorphism of the promoter region of the serotonin transporter). Compared to l/l monkeys, s allele monkeys respond to potential threat with increased activation of the bed nucleus of the stria terminalis. However, during separation from their cage mates in the absence of threat, the s allele monkeys demonstrate increased activity of the amygdala. For more information on this topic, please refer to the article by Kalin et al on pages 1021–1027.