Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Perspective
  • Published:

LIS1—no more no less

Molecular Psychiatry volume 7, pages 12–16 (2002)Cite this article

Abstract

LIS1 is one of the genes that has a principle role in brain development since hemizygote mutations in LIS1 result in a severe brain malformation known as lissencephaly (‘smooth brain’). LIS1 is a WD repeat protein and is known to be involved in several protein complexes that are likely to play a functional role in brain development. We discuss here the brain developmental phenotype observed in mice heterozygote for an N-terminal truncated LIS1 protein in view of known LIS1 protein interactions.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1

Similar content being viewed by others

References

  1. Cahana A et al. Proc Natl Acad Sci USA 2001 98: 6429–6434

  2. des Portes V et al. Cell 1998 92: 51–61

    Article  Google Scholar 

  3. Gleeson JG et al. Cell 1998 92: 63–72

    Article  CAS  Google Scholar 

  4. Reiner O et al. Nature 1993 364: 717–721

    Article  CAS  Google Scholar 

  5. Dobyns WB et al. J Am Med Ass 1993 270: 2838–2842

  6. Lo Nigro CL et al. Hum Mol Genet 1997 6: 157–164

  7. Pilz DT et al. Hum Mol Genet 1998 7: 2029–2037

  8. Fogli A et al. Ann Neurol 1999 45: 154–161

  9. Neer EJ et al. Nature 1994 371: 297–300

    Article  CAS  Google Scholar 

  10. Reiner O . Neuron 2000 28: 633–636

    Article  CAS  Google Scholar 

  11. Morris NR et al. Trends Cell Biol 1998 8: 467–470

  12. Xiang X et al. Mol Biol Cell 1995 6: 297–310

  13. Morris SM et al. Curr Biol 1998 8: 603–606

  14. Willins DA et al. Genetics 1995 141: 1287–1298

  15. Sapir T et al. EMBO J 1997 16: 6977–6984

  16. Sapir T et al. Eur J Biochem 1999 265: 181–188

    Article  CAS  Google Scholar 

  17. Beckwith SM et al. J Cell Biol 1998 143: 1239–1247

    Article  Google Scholar 

  18. Xiang X et al. Proc Natl Acad Sci USA 1994 91: 2100–2104

  19. Xiang X et al. Curr Biol 2000 10: 603–606

  20. Han G et al. Curr Biol 2001 11: 1–20

  21. Liu Z et al. Development 1999 126: 4477–4488

  22. Swan A et al. Nat Cell Biol 1999 1: 444–449

    Article  CAS  Google Scholar 

  23. Lei Y, Warrior R . Dev Biol 2000 226: 57–72

  24. Fujiwara T et al. Mol Cell Biol 1999 19: 8016–8027

  25. Sasaki S et al. Neuron 2000 28: 681–696

    Article  CAS  Google Scholar 

  26. Faulkner NE et al. Nat Cell Biol 2000 2: 784–791

    Article  CAS  Google Scholar 

  27. Smith DS et al. Nat Cell Biol 2000 2: 767–775

    Article  CAS  Google Scholar 

  28. Sharp DJ . Nature 2000 407: 41–47

    Article  CAS  Google Scholar 

  29. Goldstein LS, Yang Z . Annu Rev Neurosci 2000 23: 39–71

  30. Efimov VP, Morris NR . J Cell Biol 2000 150: 681–688

    Article  CAS  Google Scholar 

  31. Minke PF et al. Mol Microbiol 1999 32: 1065–1076

    Article  CAS  Google Scholar 

  32. Feng Y et al. Neuron 2000 28: 665–679

    Article  CAS  Google Scholar 

  33. Hayashi MA et al. Biochem Biophys Res Commun 2000 269: 7–13

  34. Niethammer M et al. Neuron 2000 28: 697–711

    Article  CAS  Google Scholar 

  35. Kitagawa M et al. FEBS Lett 2000 479: 57–62

  36. Kwon YT, Tsai LH . Results Probl Cell Differ 2000 30: 241–253

  37. Chae T et al. Neuron 1997 18: 29–42

    Article  CAS  Google Scholar 

  38. Gilmore EC et al. J Neurosci 1998 18: 6370–6377

  39. Kwon YT, Tsai LH . J Comp Neurol 1998 395: 510–522

  40. Ohshima T et al. Proc Natl Acad Sci USA 1996 93: 11173–11178

  41. Caspi M et al. Hum Mol Genet 2000 9: 2205–2213

  42. Horesh D et al. Hum Mol Genet 1999 8: 1599–1610

  43. Francis F et al. Neuron 1999 23: 247–256

    Article  CAS  Google Scholar 

  44. Gleeson JG et al. Neuron 1999 23: 257–271

    Article  CAS  Google Scholar 

  45. Sapir T et al. Hum Mol Genet 2000 5: 703–712

  46. Hattori M et al. Nature 1994 370: 216–218

    Article  CAS  Google Scholar 

  47. Manya H et al. J Biol Chem 1998 273: 18567–18572

  48. Sheffield P et al. Proteins 2000 39: 1–8

  49. Kornecki E, Ehrlich YH . Science 1988 240: 1792–1794

    Article  CAS  Google Scholar 

  50. Yue TL, Feuerstein GZ . Crit Rev Neurobiol 1994 8: 11–24

  51. Bazan NG . Prog Brain Res 1998 118: 281–291

  52. McNeil RS et al. Cell Motil Cytoskeleton 1999 43: 99–113

  53. Adachi T et al. Neurosci Lett 1997 235: 133–136

  54. Bix GJ, Clark GD . J Neurosci 1998 18: 307–318

  55. Gould SJ, Valle D . Trends Genet 2000 16: 340–345

  56. Powers JM . J Neuropathol Exp Neurol 1995 54: 710–719

  57. Baes M et al. Nat Genet 1997 17: 49–57

    Article  CAS  Google Scholar 

  58. Cahana A, Reiner O . FEBS Lett 1999 451: 99–102

  59. Hirotsune S et al. Nat Genet 1998 19: 333–339

    Article  CAS  Google Scholar 

  60. Liu Z et al. Nat Cell Biol 2000 2: 776–783

    Article  CAS  Google Scholar 

  61. Fleck MW et al. J Neurosci 2000 20: 2439–2450

  62. Sapir T et al. Eur J Biochem 1999 266: 1011–1020

  63. Ahn C, Morris NR . J Biol Chem 2001 276: 9903–9909

  64. Garcia-Higuera I et al. Biochemistry 1996 35: 13985–13994

    Article  CAS  Google Scholar 

  65. Ghosh A, Shatz CJ . Development 1993 117: 1031–1047

  66. Ghosh A et al. Nature 1990 347: 179–181

    Article  CAS  Google Scholar 

  67. Katz LC, Shatz CJ . Science 1996 274: 1133–1138

    Article  CAS  Google Scholar 

  68. Finney EM, Shatz CJ . J Neurosci 1998 18: 8826–8838

  69. Edwards MA et al. Neuroscience 1990 36: 121–144

    Article  CAS  Google Scholar 

  70. Super H et al. Brain Res Brain Res Rev 1998 27: 40–64

  71. Rakic P . Proc Natl Acad Sci USA 1995 92: 11323–11327

  72. Manya H et al. J Biol Chem 1999 274: 31827–31832

  73. Clark GD et al. Neuroreport 1995 6: 2569–2575

    Article  CAS  Google Scholar 

Download references

Acknowledgements

Supported in Part by Fritz Thyssen Stiftung Foundation, BSF grant No. 97–00014, HFSP grant No. RG283199 9, Volkswagen-Stiftung, the Israeli Science Foundation grant No. 19/00, and Minerva Foundation, to OR, and by DGSYC project PM 98–0056, Foundation Seneca of Murcia: project 00708-CV-99 and CE Contracts QLG2-CT-99–793, QLG3–00–01625 to SM. OR is an Incumbent of Aser Rothstein Career Development Chair in Genetic Diseases.

Author information

Authors and Affiliations

  1. Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel

    O Reiner & A Cahana

  2. Instituto de Neutociencias CSIC-UMH, Campus de San Juan, San Juan de Alicante, Spain

    T Escamez & S Martinez

Authors
  1. O Reiner
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A Cahana
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T Escamez
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S Martinez
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to O Reiner.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Reiner, O., Cahana, A., Escamez, T. et al. LIS1—no more no less. Mol Psychiatry 7, 12–16 (2002). https://doi.org/10.1038/sj.mp.4000975

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.mp.4000975

This article is cited by

Search

Advanced search

Quick links