Volume 16 Issue 11, November 2011

Cells co-transfected with enhanced green fluorescence protein (EGFP) (green color, top of the left panel) or EGFP tagged-dysbindin-1 (green color, bottom of the left panel) and HA tagged-necdin (red color, middle panel) shows that dysbindin-1 recruits necdin in cytoplasm. The diagram (right panel) represents that dysbindin-1 up-regulates p53 transcriptional activity by its attenuating necdin repressive effects, which in turn promotes the expressions of neurite outgrowth-related genes Coronin 1b and Rab13. For more info on this topic, please refer to the article by Ma et al. on pages 1105–1116.