1. ¹Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
2. ²Department of Statistics, University of Oxford, Oxford, UK
3. ³Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, University of Cambridge, Cambridge, UK
4. ⁴Division of Molecular and Clinical Neurobiology; Ludwig-Maximilians-University, Munich, Germany
5. ⁵Department of Psychiatry, Ludwig-Maximilians-University, Munich, Germany
6. ⁶Neuropsychiatric Genetics Research Group, School of Medicine, Trinity College Dublin, Dublin, Ireland
7. ⁷Bio-X Center, Shanghai Jiao Tong University, Shanghai, PR China
8. ⁸Shanghai Institute of Mental Health, Shanghai, PR China
9. ⁹Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
10. ¹⁰Institute of Human Genetics, University of Bonn, Bonn, Germany
11. ¹¹Department of Psychiatry, University of Bonn, Bonn, Germany
12. ¹²Division of Genetic Epidemiology in Psychiatry, Central Institute for Mental Health, Mannheim, Germany
13. ¹³Genetic Basis of Mood and Anxiety Disorders, NIMH/NIH, Bethesda, MD, USA
14. ¹⁴Department of Psychiatry, School of Medicine, Fujita Health University, Aichi, Japan
15. ¹⁵CREST, Japan Science and Technology Agency, Saitama, Japan
16. ¹⁶Department of Genetics, Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, Israel
17. ¹⁷Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, PR China
18. ¹⁸Center for Psychiatric Genetics, Evanston Northwestern Healthcare, The Northwestern University, Evanston, IL, USA
19. ¹⁹Feinberg School of Medicine, The Northwestern University, Evanston, IL, USA
20. ²⁰Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA
21. ²¹Division of Psychiatry, Department of Clinical Sciences, Umeå University, Umeå, Sweden
22. ²²HUBIN Project, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden

Correspondence: Professor MC O'Donovan or Professor MJ Owen, Department of Psychological Medicine, UWCM, Heath Park, Cardiff CF14 4XN, UK. E-mail: odonovanmc@cf.ac.uk or owenmj@cf.ac.uk

²³Individual authors listed in acknowledgements.

Received 11 August 2008; Accepted 12 August 2008; Published online 23 September 2008.

Abstract

We and others have previously reported linkage to schizophrenia on chromosome 10q25–q26 but, to date, a susceptibility gene in the region has not been identified. We examined data from 3606 single-nucleotide polymorphisms (SNPs) mapping to 10q25–q26 that had been typed in a genome-wide association study (GWAS) of schizophrenia (479 UK cases/2937 controls). SNPs with P<0.01 (n=40) were genotyped in an additional 163 UK cases and those markers that remained nominally significant at P<0.01 (n=22) were genotyped in replication samples from Ireland, Germany and Bulgaria consisting of a total of 1664 cases with schizophrenia and 3541 controls. Only one SNP, rs17101921, was nominally significant after meta-analyses across the replication samples and this was genotyped in an additional six samples from the United States/Australia, Germany, China, Japan, Israel and Sweden (n=5142 cases/6561 controls). Across all replication samples, the allele at rs17101921 that was associated in the GWAS showed evidence for association independent of the original data (OR 1.17 (95% CI 1.06–1.29), P=0.0009). The SNP maps 85 kb from the nearest gene encoding fibroblast growth factor receptor 2 (FGFR2) making this a potential susceptibility gene for schizophrenia.