Volume 12 Issue 3, May 2019

Corneal scarring can lead to irreversible visual impairment. Here, multiphoton second harmonic generation (SHG) microscopy shows immunopathologic corneal fibrosis resulting from Herpes Simplex Virus (HSV)-1 infection through forward (magenta) and reverse (cyan)collagen SHG signals. Royer et al. found that prophylactic immunity elicited from a live-attenuated HSV-1 vaccine provides antibody-mediated protection against HSV-1 pathogenesis and prevents corneal scarring following ocular challenge in mice.

Image was provided by Derek J. Royer, Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK. For more information, please see the article in this issue, pages 827-839.