ADVANCE ONLINE PUBLICATION

The latest research papers, published online ahead of print. These online versions are definitive and may be cited using the digital object identifier (DOI).
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May 26 2017

Review

Why are hematopoietic stem cells so ‘sexy’? on a search for developmental explanation Open

M Z Ratajczak

Leukemia advance online publication, May 26, 2017; doi:10.1038/leu.2017.148; accepted article preview online May 15, 2017

Original Articles

Abundant and equipotent founder cells establish and maintain acute lymphoblastic leukaemia Open

A Elder, S Bomken, I Wilson, H J Blair, S Cockell, F Ponthan, K Dormon, D Pal, O Heidenreich and J Vormoor

Leukemia advance online publication, May 26, 2017; doi:10.1038/leu.2017.140; accepted article preview online May 10, 2017

Efficacy and safety of carfilzomib regimens in multiple myeloma patients relapsing after autologous stem cell transplant: ASPIRE and ENDEAVOR outcomes Open

P Hari, M-V Mateos, R Abonour, S Knop, W Bensinger, H Ludwig, K Song, R Hajek, P Moreau, D S Siegel, S Feng, M Obreja, S K Aggarwal, K Iskander and H Goldschmidt

Leukemia advance online publication, May 26, 2017; doi:10.1038/leu.2017.122; accepted article preview online April 25, 2017

MicroRNA-146a reduces MHC-II expression via targeting JAK/STAT signaling in dendritic cells after stem cell transplantation

N Stickel, K Hanke, D Marschner, G Prinz, M Köhler, W Melchinger, D Pfeifer, A Schmitt-Graeff, T Brummer, A Heine, P Brossart, D Wolf, N von Bubnoff, J Finke, J Duyster, J Ferrara, U Salzer and R Zeiser

Leukemia advance online publication, May 26, 2017; doi:10.1038/leu.2017.137; accepted article preview online May 9, 2017

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May 23 2017

Review

The role of LNK/SH2B3 genetic alterations in myeloproliferative neoplasms and other hematological disorders

N Maslah, B Cassinat, E Verger, J-J Kiladjian and L Velazquez

Leukemia advance online publication, May 23, 2017; doi:10.1038/leu.2017.139; accepted article preview online May 9, 2017

Original Articles

Targeting HDAC3, a new partner protein of AKT in the reversal of chemoresistance in acute myeloid leukemia via DNA damage response

J Long, W Y Fang, L Chang, W H Gao, Y Shen, M Y Jia, Y X Zhang, Y Wang, H B Dou, W J Zhang, J Zhu, A B Liang, J M Li and Jiong Hu

Leukemia advance online publication, May 23, 2017; doi:10.1038/leu.2017.130; accepted article preview online May 2, 2017

Genotype-outcome correlations in pediatric AML: the impact of a monosomal karyotype in trial AML-BFM 2004 Open

M Rasche, C von Neuhoff, M Dworzak, J-P Bourquin, J Bradtke, G Göhring, G Escherich, G Fleischhack, N Graf, B Gruhn, O A Haas, T Klingebiel, B Kremens, T Lehrnbecher, A von Stackelberg, J Tchinda, Z Zemanova, C Thiede, N von Neuhoff, M Zimmermann, U Creutzig and D Reinhardt

Leukemia advance online publication, May 23, 2017; doi:10.1038/leu.2017.121; accepted article preview online April 25, 2017

Letters to the Editor

No increased prevalence of malignancies among first-degree relatives of 800 patients with chronic myeloid leukemia: a population-based study in Sweden Open

N Gunnarsson, M Höglund, L Stenke, F Sandin, M Björkholm, A Dreimane, M Lambe, B Markevärn, U Olsson-Strömberg, H Wadenvik, J Richter and A Själander

Leukemia advance online publication, May 23, 2017; doi:10.1038/leu.2017.131; accepted article preview online May 2, 2017

Lenalidomide, adriamycin, dexamethasone for induction followed by stem-cell transplant in newly diagnosed myeloma

S Knop, C Langer, M Engelhardt, L-O Mügge, A Reichle, W Rösler, F Bassermann, B Hertenstein, A Kunitz, C Röllig, H Ostermann, K Schäfer-Eckart, M Ringhoffer, A Günther, C Junghanss, H Biersack, M Schreder, A Liebert, S Held, H Einsele and R C Bargou for the Deutsche Studiengruppe Multiples Myelom (DSMM)

Leukemia advance online publication, May 23, 2017; doi:10.1038/leu.2017.124; accepted article preview online April 25, 2017

Germline SAMD9 mutation in siblings with monosomy 7 and myelodysplastic syndrome

J R Schwartz, S Wang, J Ma, T Lamprecht, M Walsh, G Song, S C Raimondi, G Wu, M F Walsh, R B McGee, C Kesserwan, K E Nichols, B E Cauff, R C Ribeiro, M Wlodarski and J M Klco

Leukemia advance online publication, May 23, 2017; doi:10.1038/leu.2017.142; accepted article preview online May 10, 2017

Improved survival in primary central nervous system lymphoma up to age 70 only: a population-based study on incidence, primary treatment and survival in the Netherlands, 1989–2015

M van der Meulen, A G Dinmohamed, O Visser, J K Doorduijn and J E C Bromberg

Leukemia advance online publication, May 23, 2017; doi:10.1038/leu.2017.128; accepted article preview online April 28, 2017

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May 19 2017

Original Article

Phase I trial of systemic administration of Edmonston strain of measles virus genetically engineered to express the sodium iodide symporter in patients with recurrent or refractory multiple myeloma

A Dispenzieri, C Tong, B LaPlant, M Q Lacy, K Laumann, D Dingli, Y Zhou, M J Federspiel, M A Gertz, S Hayman, F Buadi, M O'Connor, V J Lowe, K-W Peng and S J Russell

Leukemia advance online publication, May 19, 2017; doi:10.1038/leu.2017.120; accepted article preview online April 25, 2017

LETTER TO THE EDITOR

Possible role of pandemic AH1N1 swine flu virus in a childhood leukemia cluster Open

G Cazzaniga, L Bisanti, G Randi, S Deandrea, S Bungaro, F Pregliasco, D Perotti, F Spreafico, G Masera, M G Valsecchi, A Biondi and M Greaves

Leukemia advance online publication, May 19, 2017; doi:10.1038/leu.2017.127; accepted article preview online April 27, 2017

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May 12 2017

Editorial

Immunoglobulin gene sequence analysis in chronic lymphocytic leukemia: updated ERIC recommendations Open

R Rosenquist, P Ghia, A Hadzidimitriou, L-A Sutton, A Agathangelidis, P Baliakas, N Darzentas, V Giudicelli, M-P Lefranc, A W Langerak, C Belessi, F Davi and K Stamatopoulos ERIC, the European Research Initiative on CLL

Leukemia advance online publication, May 12, 2017; doi:10.1038/leu.2017.125; accepted article preview online April 25, 2017

Original Article

Characterization of the leukemogenic potential of distal cytoplasmic CSF3R truncation and missense mutations

H Zhang, A Reister Schultz, S Luty, A Rofelty, Y Su, S Means, D Bottomly, B Wilmot, S K McWeeney and J W Tyner

Leukemia advance online publication, May 12, 2017; doi:10.1038/leu.2017.126; accepted article preview online April 25, 2017

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May 5 2017

Original Article

Constitutively active ABL family kinases, TEL/ABL and TEL/ARG, harbor distinct leukemogenic activities in vivo

A Yokota, H Hirai, T Shoji, T Maekawa and K Okuda

Leukemia advance online publication, May 5, 2017; doi:10.1038/leu.2017.114; accepted article preview online April 7, 2017

Corrigendum

Equivalence of BCSH and WHO diagnostic criteria for ET FREE

C N Harrison, M F McMullin, A R Green and A J Mead

Leukemia advance online publication, May 5, 2017; doi:10.1038/leu.2017.119

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May 2 2017

Original Articles

Results of the randomized phase IIB ARCTIC trial of low-dose rituximab in previously untreated CLL

D R Howard, T Munir, L McParland, A C Rawstron, D Milligan, A Schuh, A Hockaday, D J Allsup, S Marshall, A S Duncombe, J L O'Dwyer, A F Smith, R Longo, A Varghese and P Hillmen

Leukemia advance online publication, May 2, 2017; doi:10.1038/leu.2017.96; accepted article preview online March 24, 2017

Dysfunction of the WT1-MEG3 signaling promotes AML leukemogenesis via p53-dependent and -independent pathways Open

Y Lyu, J Lou, Y Yang, J Feng, Y Hao, S Huang, L Yin, J Xu, D Huang, B Ma, D Zou, Y Wang, Y Zhang, B Zhang, P Chen, K Yu, E W-F Lam, X Wang, Q Liu, J Yan and B Jin

Leukemia advance online publication, May 2, 2017; doi:10.1038/leu.2017.116; accepted article preview online April 12, 2017

Letter to the Editor

Tunneling nanotubes facilitate autophagosome transfer in the leukemic niche Open

B de Rooij, R Polak, F Stalpers, R Pieters and M L den Boer

Leukemia advance online publication, May 2, 2017; doi:10.1038/leu.2017.117; accepted article preview online April 12, 2017

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April 28 2017

Original Articles

Benefit of continuous treatment for responders with newly diagnosed multiple myeloma in the randomized FIRST trial Open

N J Bahlis, A Corso, L-O Mugge, Z-X Shen, P Desjardins, A-M Stoppa, O Decaux, T de Revel, M Granell, G Marit, H Nahi, H Demuynck, S-Y Huang, S Basu, T H Guthrie, A Ervin-Haynes, J Marek, G Chen and T Facon

Leukemia advance online publication, April 28, 2017; doi:10.1038/leu.2017.111; accepted article preview online April 4, 2017

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix

S V Glavey, A Naba, S Manier, K Clauser, S Tahri, J Park, M R Reagan, M Moschetta, Y Mishima, M Gambella, A Rocci, A Sacco, M E O'Dwyer, J M Asara, A Palumbo, A M Roccaro, R O Hynes and I M Ghobrial

Leukemia advance online publication, April 28, 2017; doi:10.1038/leu.2017.102; accepted article preview online March 27, 2017

Results of the randomized phase IIB ADMIRE trial of FCR with or without mitoxantrone in previously untreated CLL

T Munir, D R Howard, L McParland, C Pocock, A C Rawstron, A Hockaday, A Varghese, M Hamblin, A Bloor, A Pettitt, C Fegan, J Blundell, J G Gribben, D Phillips and P Hillmen

Leukemia advance online publication, April 28, 2017; doi:10.1038/leu.2017.65; accepted article preview online April 20, 2017

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April 25 2017

Original Articles

HIV Tat induces a prolonged MYC relocalization next to IGH in circulating B-cells

D Germini, T Tsfasman, M Klibi, R El-Amine, A Pichugin, O V Iarovaia, C Bilhou-Nabera, F Subra, Y Bou Saada, A Sukhanova, D Boutboul, M Raphaël, J Wiels, S V Razin, S Bury-Moné, E Oksenhendler, M Lipinski and Y S Vassetzky

Leukemia advance online publication, April 25, 2017; doi:10.1038/leu.2017.106; accepted article preview online March 31, 2017

Myeloproliferative leukemia protein activation directly induces fibrocyte differentiation to cause myelofibrosis

T Maekawa, Y Osawa, T Izumi, S Nagao, K Takano, Y Okada, N Tachi, M Teramoto, T Kawamura, T Horiuchi, R Saga, S Kato, T Yamamura, J Watanabe, A Kobayashi, S Kobayashi, K Sato, M Hashimoto, S Suzu and F Kimura

Leukemia advance online publication, April 25, 2017; doi:10.1038/leu.2017.112; accepted article preview online April 3, 2017

Heterodimerization of AML1/ETO with CBFβ is required for leukemogenesis but not for myeloproliferation Open

V N Thiel, B D Giaimo, P Schwarz, K Soller, V Vas, M Bartkuhn, T J Blätte, K Döhner, L Bullinger, T Borggrefe, H Geiger and F Oswald

Leukemia advance online publication, April 25, 2017; doi:10.1038/leu.2017.105; accepted article preview online March 31, 2017

Letters to the Editor

NEK2 induces osteoclast differentiation and bone destruction via heparanase in multiple myeloma Open

M Hao, R Franqui-Machin, H Xu, J Shaughnessy Jr, B Barlogie, D Roodman, D E Quelle, S Janz, M H Tomasson, R D Sanderson, L Qiu, I Frech, G Tricot and F Zhan

Leukemia advance online publication, April 25, 2017; doi:10.1038/leu.2017.115; accepted article preview online April 12, 2017

Acute myeloid leukemia in the elderly is characterized by a distinct genetic and epigenetic landscape

P Silva, M Neumann, M P Schroeder, S Vosberg, C Schlee, K Isaakidis, J Ortiz-Tanchez, L R Fransecky, T Hartung, S Türkmen, A Graf, S Krebs, H Blum, C Müller-Tidow, C Thiede, G Ehninger, H Serve, J Hecht, W E Berdel, P A Greif, C Röllig and C D Baldus

Leukemia advance online publication, April 25, 2017; doi:10.1038/leu.2017.109; accepted article preview online April 3, 2017

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April 21 2017

Review

Measurable residual disease testing in acute myeloid leukaemia

C S Hourigan, R P Gale, N J Gormley, G J Ossenkoppele and R B Walter

Leukemia advance online publication, April 21, 2017; doi:10.1038/leu.2017.113; accepted article preview online April 7, 2017

Original Articles

A novel AHI-1–BCR-ABL–DNM2 complex regulates leukemic properties of primitive CML cells through enhanced cellular endocytosis and ROS-mediated autophagy Open

X Liu, K Rothe, R Yen, C Fruhstorfer, T Maetzig, M Chen, D L Forrest, R K Humphries and X Jiang

Leukemia advance online publication, April 21, 2017; doi:10.1038/leu.2017.108; accepted article preview online April 3, 2017

DPP4 truncated GM-CSF and IL-3 manifest distinct receptor-binding and regulatory functions compared with their full-length forms

H A O’Leary, M Capitano, S Cooper, C Mantel, H S Boswell, R Kapur, B Ramdas, R Chan, L Deng, C-K Qu and H E Broxmeyer

Leukemia advance online publication, April 21, 2017; doi:10.1038/leu.2017.98; accepted article preview online March 27, 2017

The histone deacetylase inhibitor givinostat (ITF2357) exhibits potent anti-tumor activity against CRLF2-rearranged BCP-ALL

A M Savino, J Sarno, L Trentin, M Vieri, G Fazio, M Bardini, C Bugarin, G Fossati, K L Davis, G Gaipa, S Izraeli, L H Meyer, G P Nolan, A Biondi, G Te Kronnie, C Palmi and G Cazzaniga

Leukemia advance online publication, April 21, 2017; doi:10.1038/leu.2017.93; accepted article preview online March 23, 2017

Letters to the Editor

PLCG2 C2 domain mutations co-occur with BTK and PLCG2 resistance mutations in chronic lymphocytic leukemia undergoing ibrutinib treatment

D Jones, J A Woyach, W Zhao, S Caruthers, H Tu, J Coleman, J C Byrd, A J Johnson and G Lozanski

Leukemia advance online publication, April 21, 2017; doi:10.1038/leu.2017.110; accepted article preview online April 3, 2017

Donor type, in addition to transplantation in chronic phase and myeloablative conditioning, influence transplant survival for patients with advanced chronic myeloid leukemia in the era of tyrosine kinase inhibitors

P Kongtim, K Adekola, D R Milton, R Ramlal, A Jimenez, J Chen, G Rondon, S Ahmed, P Kebriaei, O Betul, C M Hosing, U Popat, I Khouri, E Jabbour, J E Cortes, H M Kantarjian, R E Champlin and S O Ciurea

Leukemia advance online publication, April 21, 2017; doi:10.1038/leu.2017.118; accepted article preview online April 12, 2017

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April 18 2017

Review

The emerging roles of tumor-derived exosomes in hematological malignancies

M Boyiadzis and T L Whiteside

Leukemia advance online publication, April 18, 2017; doi:10.1038/leu.2017.91; accepted article preview online March 21, 2017

Original Articles

The mutational oncoprint of recurrent cytogenetic abnormalities in adult patients with de novo acute myeloid leukemia FREE

A-K Eisfeld, K Mrózek, J Kohlschmidt, D Nicolet, S Orwick, C J Walker, K W Kroll, J S Blachly, A J Carroll, J E Kolitz, B L Powell, E S Wang, R M Stone, A de la Chapelle, J C Byrd and C D Bloomfield

Leukemia advance online publication, April 18, 2017; doi:10.1038/leu.2017.86; accepted article preview online March 24, 2017

Characteristics and outcome of patients with therapy-related acute promyelocytic leukemia front-line treated with or without arsenic trioxide

S Kayser, J Krzykalla, M A Elliott, K Norsworthy, P Gonzales, R K Hills, M R Baer, Z Ráčil, J Mayer, J Novak, P Žák, T Szotkowski, D Grimwade, N H Russell, R B Walter, E H Estey, J Westermann, M Görner, A Benner, A Krämer, B D Smith, A K Burnett, C Thiede, C Röllig, A D Ho, G Ehninger, R F Schlenk, M S Tallman, M J Levis and U Platzbecker

Leukemia advance online publication, April 18, 2017; doi:10.1038/leu.2017.92; accepted article preview online March 21, 2017

NOTCH1-mutated chronic lymphocytic leukemia cells are characterized by a MYC-related overexpression of nucleophosmin 1 and ribosome-associated components

F Pozzo, T Bittolo, E Vendramini, R Bomben, P Bulian, F M Rossi, A Zucchetto, E Tissino, M Degan, G D’Arena, F Di Raimondo, F Zaja, G Pozzato, D Rossi, G Gaidano, G Del Poeta, V Gattei and M Dal Bo

Leukemia advance online publication, April 18, 2017; doi:10.1038/leu.2017.90; accepted article preview online March 21, 2017

Combined inhibition of β-catenin and Bcr–Abl synergistically targets tyrosine kinase inhibitor-resistant blast crisis chronic myeloid leukemia blasts and progenitors in vitro and in vivo

H Zhou, P Y Mak, H Mu, D H Mak, Z Zeng, J Cortes, Q Liu, M Andreeff and B Z Carter

Leukemia advance online publication, April 18, 2017; doi:10.1038/leu.2017.87

Letters to the Editor

PD-L1 is commonly expressed and transcriptionally regulated by STAT3 and MYC in ALK-negative anaplastic large-cell lymphoma

V Atsaves, N Tsesmetzis, D Chioureas, L Kis, V Leventaki, E Drakos, T Panaretakis, D Grander, L J Medeiros, K H Young and G Z Rassidakis

Leukemia advance online publication, April 18, 2017; doi:10.1038/leu.2017.103; accepted article preview online March 27, 2017

Gain in the short arm of chromosome 2 (2p+) induces gene overexpression and drug resistance in chronic lymphocytic leukemia: analysis of the central role of XPO1

A Cosson, E Chapiro, N Bougacha, J Lambert, L Herbi, H-A Cung, C Algrin, B Keren, F Damm, C Gabillaud, M-N Brunelle-Navas, F Davi, H Merle-Béral, M Le Garff-Tavernier, D Roos-Weil, S Choquet, M Uzunov, V Morel, V Leblond, K Maloum, S Lepretre, P Feugier, C Lesty, J Lejeune, L Sutton, Y Landesman, S A Susin and F Nguyen-Khac

Leukemia advance online publication, April 18, 2017; doi:10.1038/leu.2017.100; accepted article preview online March 27, 2017

Response-adapted consolidation with bortezomib after ASCT improves progression-free survival in newly diagnosed multiple myeloma

H Einsele, S Knop, M Vogel, J Müller, M Kropff, B Metzner, C Langer, H Sayer, W Jung, H A Dürk, H Salwender, H Wandt, F Bassermann, M Gramatzki, W Rösler, H-H Wolf, W Brugger, M Engelhardt, T Fischer, P Liebisch and C Straka

Leukemia advance online publication, April 18, 2017; doi:10.1038/leu.2017.83; accepted article preview online March 15, 2017

Donor cell leukemia: evidence for multiple preleukemic clones and parallel long term clonal evolution in donor and recipient

S Herold, M Kuhn, M v Bonin, T Stange, U Platzbecker, J Radke, T Lange, K Sockel, K Gutsche, J Schetelig, C Röllig, C Schuster, I Roeder, A Dahl, B Mohr, H Serve, C Brandts, G Ehninger, M Bornhäuser and C Thiede

Leukemia advance online publication, April 18, 2017; doi:10.1038/leu.2017.104; accepted article preview online March 28, 2017

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April 11 2017

Original Article

Dnmt3a regulates T-cell development and suppresses T-ALL transformation

A C Kramer, A Kothari, W C Wilson, H Celik, J Nikitas, C Mallaney, E L Ostrander, E Eultgen, A Martens, M C Valentine, A L Young, T E Druley, M E Figueroa, B Zhang and G A Challen

Leukemia advance online publication, April 11, 2017; doi:10.1038/leu.2017.89; accepted article preview online March 21, 2017

Letters to the Editor

Epigenetic loss of the RNA decapping enzyme NUDT16 mediates C-MYC activation in T-cell acute lymphoblastic leukemia Open

C Anadón, G van Tetering, H J Ferreira, C Moutinho, A Martínez-Cardús, A Villanueva, M Soler, H Heyn, S Moran, M Castro de Moura, F Setien, A Vidal, E Genescà, J M Ribera, J F Nomdedeu, S Guil and M Esteller

Leukemia advance online publication, April 11, 2017; doi:10.1038/leu.2017.99; accepted article preview online March 27, 2017

A pharmacogenomic approach validates AG-221 as an effective and on-target therapy in IDH2 mutant AML

L M Kats, S J Vervoort, R Cole, A J Rogers, G P Gregory, E Vidacs, J Li, R Nagaraja, K E Yen and R W Johnstone

Leukemia advance online publication, April 11, 2017; doi:10.1038/leu.2017.84; accepted article preview online March 10, 2017

Recurrent MYB rearrangement in blastic plasmacytoid dendritic cell neoplasm

K Suzuki, Y Suzuki, A Hama, H Muramatsu, M Nakatochi, M Gunji, D Ichikawa, M Hamada, R Taniguchi, S Kataoka, N Murakami, D Kojima, Y Sekiya, E Nishikawa, N Kawashima, A Narita, N Nishio, Y Nakazawa, H Iwafuchi, K-i Watanabe, Y Takahashi, M Ito, S Kojima, S Kato and Y Okuno

Leukemia advance online publication, April 11, 2017; doi:10.1038/leu.2017.101; accepted article preview online March 27, 2017

No evidence for microsatellite instability in acute myeloid leukemia

C J Walker, A-K Eisfeld, L K Genutis, M Bainazar, J Kohlschmidt, K Mrózek, A J Carroll, J E Kolitz, B L Powell, E S Wang, R M Stone, R Bundschuh, A de la Chapelle and C D Bloomfield

Leukemia advance online publication, April 11, 2017; doi:10.1038/leu.2017.97; accepted article preview online March 24, 2017

Corrigendum

Cobll1 is linked to drug resistance and blastic transformation in chronic myeloid leukemia FREE

S H Han, S-H Kim, H-J Kim, Y Lee, S-Y Choi, G Park, D-H Kim, A Lee, J Kim, J-M Choi, Y Kim, K Myung, H Kim and D-W Kim

Leukemia advance online publication, April 11, 2017; doi:10.1038/leu.2017.107

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April 7 2017

Original Articles

The CXCR4 inhibitor BL-8040 induces the apoptosis of AML blasts by downregulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression

M Abraham, S Klein, B Bulvik, H Wald, I D Weiss, D Olam, L Weiss, K Beider, O Eizenberg, O Wald, E Galun, A Avigdor, O Benjamini, A Nagler, Y Pereg, S Tavor and A Peled

Leukemia advance online publication, April 7, 2017; doi:10.1038/leu.2017.82; accepted article preview online March 10, 2017

Decision analysis of allogeneic hematopoietic stem cell transplantation for patients with myelodysplastic syndrome stratified according to the revised International Prognostic Scoring System

M G Della Porta, C H Jackson, E P Alessandrino, M Rossi, A Bacigalupo, M T van Lint, M Bernardi, B Allione, A Bosi, S Guidi, V Santini, L Malcovati, M Ubezio, C Milanesi, E Todisco, M T Voso, P Musto, F Onida, A P Iori, R Cerretti, G Grillo, A Molteni, P Pioltelli, L Borin, E Angelucci, E Oldani, S Sica, C Pascutto, V Ferretti, A Santoro, F Bonifazi, M Cazzola and A Rambaldi on behalf of the Gruppo Italiano Trapianto di Midollo Osseo (GITMO, www.gitmo.it)

Leukemia advance online publication, April 7, 2017; doi:10.1038/leu.2017.88; accepted article preview online March 21, 2017

Alloreactivity: the Janus-face of hematopoietic stem cell transplantation Open

A Gratwohl, A Sureda, J Cornelissen, J Apperley, P Dreger, R Duarte, H T Greinix, E Mc Grath, N Kroeger, F Lanza, A Nagler, J A Snowden, D Niederwieser and R Brand for the European Society for Blood and Marrow Transplantation (EBMT)

Leukemia advance online publication, April 7, 2017; doi:10.1038/leu.2017.79; accepted article preview online March 8, 2017

Letters to the Editor

ZDHHC11 and ZDHHC11B are critical novel components of the oncogenic MYC-miR-150-MYB network in Burkitt lymphoma

A Dzikiewicz-Krawczyk, K Kok, I Slezak-Prochazka, J-L Robertus, J Bruining, M M Tayari, B Rutgers, D de Jong, J Koerts, A Seitz, J Li, B Tillema, J E Guikema, I M Nolte, A Diepstra, L Visser, J Kluiver and A van den Berg

Leukemia advance online publication, April 7, 2017; doi:10.1038/leu.2017.94; accepted article preview online March 23, 2017

Decreased spermatogonial quantity in prepubertal boys with leukaemia treated with alkylating agents Open

M Poganitsch-Korhonen, I Masliukaite, M Nurmio, P Lähteenmäki, M van Wely, A M M van Pelt, K Jahnukainen and J-B Stukenborg

Leukemia advance online publication, April 7, 2017; doi:10.1038/leu.2017.76; accepted article preview online March 8, 2017

Corrigendum

Epistasis between TIFAB and miR-146a: neighboring genes in del(5q) myelodysplastic syndrome FREE

M E Varney, K Choi, L Bolanos, S Christie, J Fang, H L Grimes, J P Maciejewski, J-I Inoue and D T Starczynowski

Leukemia advance online publication, April 7, 2017; doi:10.1038/leu.2017.95

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March 28 2017

Original Articles

Differential signaling through p190 and p210 BCR-ABL fusion proteins revealed by interactome and phosphoproteome analysis

J A Cutler, R Tahir, S K Sreenivasamurthy, C Mitchell, S Renuse, R S Nirujogi, A H Patil, M Heydarian, X Wong, X Wu, T-C Huang, M-S Kim, K L Reddy and A Pandey

Leukemia advance online publication, March 28, 2017; doi:10.1038/leu.2017.61; accepted article preview online February 17, 2017

Increased megakaryocytic proliferation, pro-platelet deposition and expression of fibrosis-associated factors in children with chronic myeloid leukaemia with bone marrow fibrosis

K Hussein, A Stucki-Koch, G Göhring, H Kreipe and M Suttorp

Leukemia advance online publication, March 28, 2017; doi:10.1038/leu.2017.73; accepted article preview online February 27, 2017

APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL Open

Z Li, B J Abraham, A Berezovskaya, N Farah, Y Liu, T Leon, A Fielding, S H Tan, T Sanda, A S Weintraub, B Li, S Shen, J Zhang, M R Mansour, R A Young and A T Look

Leukemia advance online publication, March 28, 2017; doi:10.1038/leu.2017.75; accepted article preview online March 6, 2017

High mTORC1 activity drives glycolysis addiction and sensitivity to G6PD inhibition in acute myeloid leukemia cells

L Poulain, P Sujobert, F Zylbersztejn, S Barreau, L Stuani, M Lambert, T L Palama, V Chesnais, R Birsen, F Vergez, T Farge, C Chenevier-Gobeaux, M Fraisse, F Bouillaud, C Debeissat, O Herault, C Récher, C Lacombe, M Fontenay, P Mayeux, T T Maciel, J-C Portais, J-E Sarry, J Tamburini, D Bouscary and N Chapuis

Leukemia advance online publication, March 28, 2017; doi:10.1038/leu.2017.81; accepted article preview online March 10, 2017

Autologous bone marrow Th cells can support multiple myeloma cell proliferation in vitro and in xenografted mice

D Wang, Y Fløisand, C V Myklebust, S Bürgler, A Parente-Ribes, P O Hofgaard, B Bogen, K Taskén, G E Tjønnfjord, F Schjesvold, J Dalgaard, A Tveita and L A Munthe

Leukemia advance online publication, March 28, 2017; doi:10.1038/leu.2017.69; accepted article preview online February 24, 2017

Regulation of PI3K signaling in T-cell acute lymphoblastic leukemia: a novel PTEN/Ikaros/miR-26b mechanism reveals a critical targetable role for PIK3CD

T Yuan, Y Yang, J Chen, W Li, W Li, Q Zhang, Y Mi, R S Goswami, J Q You, D Lin, M D Qian, S Calin, Y Liang, R N Miranda, G A Calin, X Zhou, L Ma, P A Zweidler-McKay, B Liu, A P Weng, L J Medeiros, Y Zhang and M J You

Leukemia advance online publication, March 28, 2017; doi:10.1038/leu.2017.80; accepted article preview online March 10, 2017

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March 24 2017

Original Articles

Imetelstat, a telomerase inhibitor, differentially affects normal and malignant megakaryopoiesis

G Mosoyan, T Kraus, F Ye, K Eng, J D Crispino, R Hoffman and C Iancu-Rubin

Leukemia advance online publication, March 24, 2017; doi:10.1038/leu.2017.78

HBZ-mediated shift of JunD from growth suppressor to tumor promoter in leukemic cells by inhibition of ribosomal protein S25 expression

M Terol, H Gazon, I Lemasson, M Duc-Dodon, B Barbeau, R Césaire, J-M Mesnard and J-M Péloponèse Jr

Leukemia advance online publication, March 24, 2017; doi:10.1038/leu.2017.74

Letter to the Editor

Early death rates remain high in high-risk APL: update from the Swedish Acute Leukemia Registry 1997–2013

S Lehmann, S Deneberg, P Antunovic, Å Rangert-Derolf, H Garelius, V Lazarevic, K Myhr-Eriksson, L Möllgård, B Uggla, A Wahlin, L Wennström, M Höglund and G Juliusson

Leukemia advance online publication, March 24, 2017; doi:10.1038/leu.2017.71; accepted article preview online February 24, 2017

Corrigendum

A clinical trial for patients with acute myeloid leukemia or myelodysplastic syndromes not eligible for standard clinical trials FREE

G Montalban-Bravo, X Huang, K Naqvi, E Jabbour, G Borthakur, C D DiNardo, N Pemmaraju, J Cortes, S Verstovsek, T Kadia, N Daver, W Wierda, Y Alvarado, M Konopleva, F Ravandi, Z Estrov, N Jain, A Alfonso, M Brandt, T Sneed, H C Chen, H Yang, C Bueso-Ramos, S Pierce, E Estey, Z Bohannan, H M Kantarjian and G Garcia-Manero

Leukemia advance online publication, March 24, 2017; doi:10.1038/leu.2017.85

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March 21 2017

Original Article

Fully human CD19-specific chimeric antigen receptors for T-cell therapy FREE

D Sommermeyer, T Hill, S M Shamah, A I Salter, Y Chen, K M Mohler and S R Riddell

Leukemia advance online publication, March 21, 2017; doi:10.1038/leu.2017.57; accepted article preview online February 16, 2017

Corrigendum

Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells FREE

W Fiskus, S Sharma, B Shah, B P Portier, S G T Devaraj, K Liu, S P Iyer, D Bearss and K N Bhalla

Leukemia advance online publication, March 21, 2017; doi:10.1038/leu.2017.77

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March 17 2017

Editorial

How good are we at predicting the fate of someone with acute myeloid leukaemia?

E Estey and R P Gale

Leukemia advance online publication, March 17, 2017; doi:10.1038/leu.2017.56

Original Article

Treatment-free remission following frontline nilotinib in patients with chronic myeloid leukemia in chronic phase: results from the ENESTfreedom study Open

A Hochhaus, T Masszi, F J Giles, J P Radich, D M Ross, M T Gómez Casares, A Hellmann, J Stentoft, E Conneally, V García-Gutiérrez, N Gattermann, W Wiktor-Jedrzejczak, P D le Coutre, B Martino, S Saussele, H D Menssen, W Deng, N Krunic, V Bedoucha and G Saglio

Leukemia advance online publication, March 17, 2017; doi:10.1038/leu.2017.63; accepted article preview online February 20, 2017

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March 14 2017

Original Articles

The T-ALL related gene BCL11B regulates the initial stages of human T-cell differentiation

V L Ha, A Luong, F Li, D Casero, J Malvar, Y M Kim, R Bhatia, G M Crooks and C Parekh

Leukemia advance online publication, March 14, 2017; doi:10.1038/leu.2017.70; accepted article preview online February 24, 2017

Cobll1 is linked to drug resistance and blastic transformation in chronic myeloid leukemia

S H Han, S-H Kim, H-J Kim, Y Lee, S-Y Choi, G Park, D-H Kim, A Lee, J Kim, J-M Choi, Y Kim, K Myung, H Kim and D-W Kim

Leukemia advance online publication, March 14, 2017; doi:10.1038/leu.2017.72; accepted article preview online February 24, 2017

Genomic profiling of Acute lymphoblastic leukemia in ataxia telangiectasia patients reveals tight link between ATM mutations and chromothripsis

M Ratnaparkhe, M Hlevnjak, T Kolb, A Jauch, K K Maass, F Devens, A Rode, V Hovestadt, A Korshunov, A Pastorczak, W Mlynarski, S Sungalee, J Korbel, J Hoell, U Fischer, T Milde, C Kramm, M Nathrath, K Chrzanowska, E Tausch, M Takagi, T Taga, S Constantini, J Loeffen, J Meijerink, S Zielen, G Gohring, B Schlegelberger, E Maass, R Siebert, J Kunz, A E Kulozik, B Worst, D T Jones, S M Pfister, M Zapatka, P Lichter and A Ernst

Leukemia advance online publication, March 14, 2017; doi:10.1038/leu.2017.55; accepted article preview online February 15, 2017

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March 10 2017

Original Articles

AMKL chimeric transcription factors are potent inducers of leukemia

J Dang, S Nance, J Ma, J Cheng, M P Walsh, P Vogel, J Easton, G Song, M Rusch, A L Gedman, C Koss, J R Downing and T A Gruber

Leukemia advance online publication, March 10, 2017; doi:10.1038/leu.2017.51; accepted article preview online February 8, 2017

miR-194-5p/BCLAF1 deregulation in AML tumorigenesis Open

C Dell'Aversana, C Giorgio, L D'Amato, G Lania, F Matarese, S Saeed, A Di Costanzo, V Belsito Petrizzi, C Ingenito, J H A Martens, I Pallavicini, S Minucci, A Carissimo, H G Stunnenberg and L Altucci

Leukemia advance online publication, March 10, 2017; doi:10.1038/leu.2017.64; accepted article preview online February 20, 2017

Inhibition of serotonin receptor type 1 in acute myeloid leukemia impairs leukemia stem cell functionality: a promising novel therapeutic target

A Etxabe, M C Lara-Castillo, J M Cornet-Masana, A Banús-Mulet, M Nomdedeu, M A Torrente, M Pratcorona, M Díaz-Beyá, J Esteve and R M Risueño

Leukemia advance online publication, March 10, 2017; doi:10.1038/leu.2017.52; accepted article preview online February 14, 2017

Next Generation Flow for highly sensitive and standardized detection of minimal residual disease in multiple myeloma Open

J Flores-Montero, L Sanoja-Flores, B Paiva, N Puig, O García-Sánchez, S Böttcher, V H J van der Velden, J-J Pérez-Morán, M-B Vidriales, R García-Sanz, C Jimenez, M González, J Martínez-López, A Corral-Mateos, G-E Grigore, R Fluxá, R Pontes, J Caetano, L Sedek, M-C del Cañizo, J Bladé, J-J Lahuerta, C Aguilar, A Bárez, A García-Mateo, J Labrador, P Leoz, C Aguilera-Sanz, J San-Miguel, M-V Mateos, B Durie, J J M van Dongen and A Orfao

Leukemia advance online publication, March 10, 2017; doi:10.1038/leu.2017.29; accepted article preview online January 20, 2017

MLL is essential for NUP98-HOXA9-induced leukemia

Y Shima, M Yumoto, T Katsumoto and I Kitabayashi

Leukemia advance online publication, March 10, 2017; doi:10.1038/leu.2017.62; accepted article preview online February 17, 2017

A novel LSD1 inhibitor NCD38 ameliorates MDS-related leukemia with complex karyotype by attenuating leukemia programs via activating super-enhancers

N Sugino, M Kawahara, G Tatsumi, A Kanai, H Matsui, R Yamamoto, Y Nagai, S Fujii, Y Shimazu, M Hishizawa, T Inaba, A Andoh, T Suzuki and A Takaori-Kondo

Leukemia advance online publication, March 10, 2017; doi:10.1038/leu.2017.59; accepted article preview online February 17, 2017

RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma Open

E Viziteu, B Klein, J Basbous, Y-L Lin, C Hirtz, C Gourzones, L Tiers, A Bruyer, L Vincent, C Grandmougin, A Seckinger, H Goldschmidt, A Constantinou, P Pasero, D Hose and J Moreaux

Leukemia advance online publication, March 10, 2017; doi:10.1038/leu.2017.54; accepted article preview online February 10, 2017

Validation of risk stratification models in acute myeloid leukemia using sequencing-based molecular profiling

M Wang, J Lindberg, D Klevebring, C Nilsson, A S Mer, M Rantalainen, S Lehmann and H Grönberg

Leukemia advance online publication, March 10, 2017; doi:10.1038/leu.2017.48; accepted article preview online February 7, 2017

Letters to the Editor

CBFβ-SMMHC regulates ribosomal gene transcription and alters ribosome biogenesis

G Cordonnier, A Mandoli, A Radhouane, G Hypolite, L Lhermitte, M Belhocine, V Asnafi, E Macintyre, J H A Martens, S Fumagalli and J Bond

Leukemia advance online publication, March 10, 2017; doi:10.1038/leu.2017.53; accepted article preview online February 15, 2017

Phosphatase PRL2 promotes AML1-ETO-induced acute myeloid leukemia

M Kobayashi, S Chen, Y Bai, C Yao, R Gao, X-J Sun, C Mu, T A Twiggs, Z-H Yu, H S Boswell, M C Yoder, R Kapur, J C Mulloy, Z-Y Zhang and Y Liu

Leukemia advance online publication, March 10, 2017; doi:10.1038/leu.2017.67; accepted article preview online February 21, 2017

Analytical and clinical validation of a novel in-house deep-sequencing method for minimal residual disease monitoring in a phase II trial for multiple myeloma Open

J Martinez-Lopez, B Sanchez-Vega, S Barrio, I Cuenca, Y Ruiz-Heredia, R Alonso, I Rapado, C Marin, M-T Cedena, B Paiva, N Puig, M-V Mateos, R Ayala, M-T Hernández, C Jimenez, L Rosiñol, R Martínez, A-I Teruel, N Gutiérrez, M-L Martin-Ramos, A Oriol, J Bargay, J Bladé, J San-Miguel, R Garcia-Sanz and J-J Lahuerta

Leukemia advance online publication, March 10, 2017; doi:10.1038/leu.2017.58; accepted article preview online February 17, 2017

Impact of treatment site on disparities in outcome among adolescent and young adults with Hodgkin lymphoma

J Wolfson, C-L Sun, L Wyatt, W Stock and S Bhatia

Leukemia advance online publication, March 10, 2017; doi:10.1038/leu.2017.66; accepted article preview online February 20, 2017

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February 24 2017

Original Articles

Pan-mutant-IDH1 inhibitor BAY1436032 is highly effective against human IDH1 mutant acute myeloid leukemia in vivo

A Chaturvedi, L Herbst, S Pusch, L Klett, R Goparaju, D Stichel, S Kaulfuss, O Panknin, K Zimmermann, L Toschi, R Neuhaus, A Haegebarth, H Rehwinkel, H Hess-Stumpp, M Bauser, T Bochtler, E A Struys, A Sharma, A Bakkali, R Geffers, M M Araujo-Cruz, F Thol, R Gabdoulline, A Ganser, A D Ho, A von Deimling, K Rippe, M Heuser and A Krämer

Leukemia advance online publication, February 24, 2017; doi:10.1038/leu.2017.46; accepted article preview online January 31, 2017

Frequency of regulatory T cells determines the outcome of the T-cell-engaging antibody blinatumomab in patients with B-precursor ALL Open

J Duell, M Dittrich, T Bedke, T Mueller, F Eisele, A Rosenwald, L Rasche, E Hartmann, T Dandekar, H Einsele and M S Topp

Leukemia advance online publication, February 24, 2017; doi:10.1038/leu.2017.41; accepted article preview online January 25, 2017

Differential signaling networks of Bcr–Abl p210 and p190 kinases in leukemia cells defined by functional proteomics Open

S Reckel, R Hamelin, S Georgeon, F Armand, Q Jolliet, D Chiappe, M Moniatte and O Hantschel

Leukemia advance online publication, February 24, 2017; doi:10.1038/leu.2017.36; accepted article preview online January 23, 2017

Comparison of clinical outcomes and prognostic utility of risk stratification tools in patients with therapy-related vs de novo myelodysplastic syndromes: a report on behalf of the MDS Clinical Research Consortium

A M Zeidan, N Al Ali, J Barnard, E Padron, J E Lancet, M A Sekeres, D P Steensma, A DeZern, G Roboz, E Jabbour, G Garcia-Manero, A List and R Komrokji

Leukemia advance online publication, February 24, 2017; doi:10.1038/leu.2017.33; accepted article preview online January 23, 2017

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February 17 2017

Original Articles

Leukemia-cell proliferation and disease progression in patients with early stage chronic lymphocytic leukemia

E J Murphy, D S Neuberg, L Z Rassenti, G Hayes, R Redd, C Emson, K Li, J R Brown, W G Wierda, S Turner, A W Greaves, C S Zent, J C Byrd, C McConnel, J Barrientos, N Kay, M K Hellerstein, N Chiorazzi, T J Kipps and K R Rai

Leukemia advance online publication, February 17, 2017; doi:10.1038/leu.2017.34; accepted article preview online January 24, 2017

Transfer of minimally manipulated CMV-specific T cells from stem cell or third-party donors to treat CMV infection after allo-HSCT

M Neuenhahn, J Albrecht, M Odendahl, F Schlott, G Dössinger, M Schiemann, S Lakshmipathi, K Martin, D Bunjes, S Harsdorf, E M Weissinger, H Menzel, M Verbeek, L Uharek, N Kröger, E Wagner, G Kobbe, T Schroeder, M Schmitt, G Held, W Herr, L Germeroth, H Bonig, T Tonn, H Einsele, D H Busch and G U Grigoleit

Leukemia advance online publication, February 17, 2017; doi:10.1038/leu.2017.16; accepted article preview online January 16, 2017

RUNX3 is oncogenic in natural killer/T-cell lymphoma and is transcriptionally regulated by MYC

V Selvarajan, M Osato, G S S Nah, J Yan, T-H Chung, D C-C Voon, Y Ito, M F Ham, M Salto-Tellez, N Shimizu, S-N Choo, S Fan, W-J Chng and S-B Ng

Leukemia advance online publication, February 17, 2017; doi:10.1038/leu.2017.40; accepted article preview online January 25, 2017

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February 14 2017

Original Articles

Bruton’s tyrosine kinase inhibition increases BCL-2 dependence and enhances sensitivity to venetoclax in chronic lymphocytic leukemia

J Deng, E Isik, S M Fernandes, J R Brown, A Letai and M S Davids

Leukemia advance online publication, February 14, 2017; doi:10.1038/leu.2017.32; accepted article preview online January 23, 2017

ITD mutation in FLT3 tyrosine kinase promotes Warburg effect and renders therapeutic sensitivity to glycolytic inhibition

H-Q Ju, G Zhan, A Huang, Y Sun, S Wen, J Yang, W-h Lu, R-h Xu, J Li, Y Li, G Garcia-Manero, P Huang and Y Hu

Leukemia advance online publication, February 14, 2017; doi:10.1038/leu.2017.45; accepted article preview online January 31, 2017

Impact of pretransplant induction therapy on autologous stem cell transplantation for patients with newly diagnosed POEMS syndrome

J Li, M-H Duan, C Wang, X-F Huang, W Zhang, X-X Cao, T-N Zhu, J-L Zhuang, B Han, H Cai, H-C Cai and D-B Zhou

Leukemia advance online publication, February 14, 2017; doi:10.1038/leu.2017.27; accepted article preview online January 19, 2017

Bortezomib and thalidomide maintenance after stem cell transplantation for multiple myeloma: a PETHEMA/GEM trial

L Rosiñol, A Oriol, A I Teruel, A L de la Guía, MaJ Blanchard, J de la Rubia, M Granell, MaA Sampol, L Palomera, Y González, MaA Etxebeste, R Martínez-Martínez, M T Hernández, F de Arriba, A Alegre, MaT Cibeira, MaV Mateos, J Martínez-López, J J Lahuerta, J San Miguel and J Bladé on behalf of the Programa Español de Tratamientos en Hematología/Grupo Español de Mieloma (PETHEMA/GEM)

Leukemia advance online publication, February 14, 2017; doi:10.1038/leu.2017.35; accepted article preview online January 23, 2017

Outcomes of UCB transplantation are comparable in FLT3+ AML: results of CIBMTR, EUROCORD and EBMT collaborative analysis

C Ustun, F Giannotti, M-J Zhang, H-L Wang, C Brunstein, M Labopin, V Rocha, M de Lima, F Baron, B M Sandmaier, M Eapen, E Gluckman, A Nagler, D J Weisdorf and A Ruggeri

Leukemia advance online publication, February 14, 2017; doi:10.1038/leu.2017.42; accepted article preview online January 25, 2017

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February 10 2017

Original Articles

Preclinical targeting of aggressive T-cell malignancies using anti-CD5 chimeric antigen receptor Open

K H Chen, M Wada, K G Pinz, H Liu, K-W Lin, A Jares, A E Firor, X Shuai, H Salman, M Golightly, F Lan, L Senzel, E L Leung, X Jiang and Y Ma

Leukemia advance online publication, February 10, 2017; doi:10.1038/leu.2017.8; accepted article preview online January 12, 2017

Novel therapeutic approach to improve hematopoiesis in low risk MDS by targeting MDSCs with the Fc-engineered CD33 antibody BI 836858

E A Eksioglu, X Chen, K-H Heider, B Rueter, K L McGraw, A A Basiorka, M Wei, A Burnette, P Cheng, J Lancet, R Komrokji, J Djeu, A List and S Wei

Leukemia advance online publication, February 10, 2017; doi:10.1038/leu.2017.21; accepted article preview online January 18, 2017

O-GlcNAcylation of STAT5 controls tyrosine phosphorylation and oncogenic transcription in STAT5-dependent malignancies Open

P Freund, M A Kerenyi, M Hager, T Wagner, B Wingelhofer, H T T Pham, M Elabd, X Han, P Valent, F Gouilleux, V Sexl, O H Krämer, B Groner and R Moriggl

Leukemia advance online publication, February 10, 2017; doi:10.1038/leu.2017.4; accepted article preview online January 11, 2017

Genetics of ancestry-specific risk for relapse in acute lymphoblastic leukemia

S E Karol, E Larsen, C Cheng, X Cao, W Yang, L B Ramsey, C A Fernandez, J R McCorkle, S W Paugh, R J Autry, E Lopez-Lopez, B Diouf, S Jeha, C-H Pui, E A Raetz, N J Winick, W L Carroll, S P Hunger, M L Loh, M Devidas, W E Evans, J J Yang and M V Relling

Leukemia advance online publication, February 10, 2017; doi:10.1038/leu.2017.24; accepted article preview online January 18, 2017

Impact of salvage regimens on response and overall survival in acute myeloid leukemia with induction failure

M Wattad, D Weber, K Döhner, J Krauter, V I Gaidzik, P Paschka, M Heuser, F Thol, T Kindler, M Lübbert, H R Salih, A Kündgen, H-A Horst, P Brossart, K Götze, D Nachbaur, C-H Köhne, M Ringhoffer, G Wulf, G Held, H Salwender, A Benner, A Ganser, H Döhner and R F Schlenk for the German-Austrian AMLSG

Leukemia advance online publication, February 10, 2017; doi:10.1038/leu.2017.23; accepted article preview online January 19, 2017

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February 3 2017

Original Articles

Carfilzomib–dexamethasone vs bortezomib–dexamethasone in relapsed or refractory multiple myeloma by cytogenetic risk in the phase 3 study ENDEAVOR Open

W-J Chng, H Goldschmidt, M A Dimopoulos, P Moreau, D Joshua, A Palumbo, T Facon, H Ludwig, L Pour, R Niesvizky, A Oriol, L Rosiñol, A Suvorov, G Gaidano, T Pika, K Weisel, V Goranova-Marinova, H H Gillenwater, N Mohamed, S Feng, S Aggarwal and R Hájek

Leukemia advance online publication, February 3, 2017; doi:10.1038/leu.2016.390; accepted article preview online December 27, 2016

Effects of miRNA-15 and miRNA-16 expression replacement in chronic lymphocytic leukemia: implication for therapy

G Cutrona, S Matis, M Colombo, C Massucco, G Baio, F Valdora, L Emionite, S Fabris, A G Recchia, M Gentile, C E Neumaier, D Reverberi, R Massara, S Boccardo, L Basso, S Salvi, F Rosa, M Cilli, S Zupo, M Truini, P Tassone, M Calabrese, M Negrini, A Neri, F Morabito, F Fais and M Ferrarini

Leukemia advance online publication, February 3, 2017; doi:10.1038/leu.2016.394; accepted article preview online January 5, 2017

Mass cytometry analysis reveals hyperactive NF Kappa B signaling in myelofibrosis and secondary acute myeloid leukemia

D A C Fisher, O Malkova, E K Engle, C A Miner, M C Fulbright, G K Behbehani, T B Collins, S Bandyopadhyay, A Zhou, G P Nolan and S T Oh

Leukemia advance online publication, February 3, 2017; doi:10.1038/leu.2016.377; accepted article preview online December 23, 2016

Direct in vivo evidence for increased proliferation of CLL cells in lymph nodes compared to bone marrow and peripheral blood

T M Herndon, S-S Chen, N S Saba, J Valdez, C Emson, M Gatmaitan, X Tian, T E Hughes, C Sun, D C Arthur, M Stetler-Stevenson, C M Yuan, C U Niemann, G E Marti, G Aue, S Soto, M Z H Farooqui, S E M Herman, N Chiorazzi and A Wiestner

Leukemia advance online publication, February 3, 2017; doi:10.1038/leu.2017.11; accepted article preview online January 11, 2017

The clonal origins of leukemic progression of myelodysplasia

T Kim, M S Tyndel, H J Kim, J-S Ahn, S H Choi, H J Park, Y-k Kim, D-H Yang, J-J Lee, S-H Jung, S Y Kim, Y H Min, J-W Cheong, S K Sohn, J H Moon, M Choi, M Lee, Z Zhang and D(D H) Kim

Leukemia advance online publication, February 3, 2017; doi:10.1038/leu.2017.17; accepted article preview online January 16, 2017

Duvelisib treatment is associated with altered expression of apoptotic regulators that helps in sensitization of chronic lymphocytic leukemia cells to venetoclax (ABT-199)

V M Patel, K Balakrishnan, M Douglas, T Tibbitts, E Y Xu, J L Kutok, M Ayers, A Sarkar, R Guerrieri, W G Wierda, S O'Brien, N Jain, H M Stern and V Gandhi

Leukemia advance online publication, February 3, 2017; doi:10.1038/leu.2016.382; accepted article preview online December 26, 2016

Targeting BET proteins improves the therapeutic efficacy of BCL-2 inhibition in T-cell acute lymphoblastic leukemia

S Peirs, V Frismantas, F Matthijssens, W Van Loocke, T Pieters, N Vandamme, B Lintermans, M P Dobay, G Berx, B Poppe, S Goossens, B C Bornhauser, J-P Bourquin and P Van Vlierberghe

Leukemia advance online publication, February 3, 2017; doi:10.1038/leu.2017.10; accepted article preview online January 11, 2017

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January 31 2017

Original Articles

Mutations in NOTCH1 PEST domain orchestrate CCL19-driven homing of chronic lymphocytic leukemia cells by modulating the tumor suppressor gene DUSP22

F Arruga, B Gizdic, C Bologna, S Cignetto, R Buonincontri, S Serra, T Vaisitti, K Gizzi, N Vitale, G Garaffo, E Mereu, F Diop, F Neri, D Incarnato, M Coscia, J Allan, R Piva, S Oliviero, R R Furman, D Rossi, G Gaidano and S Deaglio

Leukemia advance online publication, January 31, 2017; doi:10.1038/leu.2016.383; accepted article preview online December 26, 2016

EphA3 as a target for antibody immunotherapy in acute lymphoblastic leukemia Open

S Charmsaz, F Al-Ejeh, T M Yeadon, K J Miller, F M Smith, B W Stringer, A S Moore, F-T Lee, L T Cooper, C Stylianou, G T Yarranton, J Woronicz, A M Scott, M Lackmann and A W Boyd

Leukemia advance online publication, January 31, 2017; doi:10.1038/leu.2016.371; accepted article preview online December 6, 2016

A CpG island methylator phenotype in acute myeloid leukemia independent of IDH mutations and associated with a favorable outcome

A D Kelly, H Kroeger, J Yamazaki, R Taby, F Neumann, S Yu, J T Lee, B Patel, Y Li, R He, S Liang, Y Lu, M Cesaroni, S A Pierce, S M Kornblau, C E Bueso-Ramos, F Ravandi, H M Kantarjian, J Jelinek and J-PJ Issa

Leukemia advance online publication, January 31, 2017; doi:10.1038/leu.2017.12; accepted article preview online January 11, 2017

PPAR-delta promotes survival of chronic lymphocytic leukemia cells in energetically unfavorable conditions

Y-J Li, L Sun, Y Shi, G Wang, X Wang, S E Dunn, C Iorio, R A Screaton and D E Spaner

Leukemia advance online publication, January 31, 2017; doi:10.1038/leu.2016.395; accepted article preview online January 4, 2017

Novel inhibition of PIM2 kinase has significant anti-tumor efficacy in multiple myeloma

J R Nair, J Caserta, K Belko, T Howell, G Fetterly, C Baldino and K P Lee

Leukemia advance online publication, January 31, 2017; doi:10.1038/leu.2016.379; accepted article preview online December 23, 2016

Enhanced MAPK signaling is essential for CSF3R-induced leukemia

S Rohrabaugh, M Kesarwani, Z Kincaid, E Huber, J Leddonne, Z Siddiqui, Y Khalifa, K Komurov, H L Grimes and M Azam

Leukemia advance online publication, January 31, 2017; doi:10.1038/leu.2016.376; accepted article preview online December 27, 2016

Novel BET protein proteolysis-targeting chimera exerts superior lethal activity than bromodomain inhibitor (BETi) against post-myeloproliferative neoplasm secondary (s) AML cells

D T Saenz, W Fiskus, Y Qian, T Manshouri, K Rajapakshe, K Raina, K G Coleman, A P Crew, A Shen, C P Mill, B Sun, P Qiu, T M Kadia, N Pemmaraju, C DiNardo, M-S Kim, A J Nowak, C Coarfa, C M Crews, S Verstovsek and K N Bhalla

Leukemia advance online publication, January 31, 2017; doi:10.1038/leu.2016.393; accepted article preview online February 2, 2017

Activating JAK2 mutants reveal cytokine receptor coupling differences that impact outcomes in myeloproliferative neoplasm

H Yao, Y Ma, Z Hong, L Zhao, S A Monaghan, M-C Hu and L J Huang

Leukemia advance online publication, January 31, 2017; doi:10.1038/leu.2017.1; accepted article preview online January 6, 2017

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January 27 2017

Original Article

Aberrant activation of the GIMAP enhancer by oncogenic transcription factors in T-cell acute lymphoblastic leukemia

W S Liau, S H Tan, P C T Ngoc, C Q Wang, V Tergaonkar, H Feng, Z Gong, M Osato, A T Look and T Sanda

Leukemia advance online publication, January 27, 2017; doi:10.1038/leu.2016.392; accepted article preview online December 28, 2016

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January 24 2017

Original Articles

Autologous transplant vs oral chemotherapy and lenalidomide in newly diagnosed young myeloma patients: a pooled analysis

F Gay, S Oliva, M T Petrucci, V Montefusco, C Conticello, P Musto, L Catalano, A Evangelista, S Spada, P Campbell, R Ria, M Salvini, M Offidani, A M Carella, P Omedé, A M Liberati, R Troia, A M Cafro, A Malfitano, A P Falcone, T Caravita, F Patriarca, A Nagler, A Spencer, R Hajek, A Palumbo and M Boccadoro

Leukemia advance online publication, January 24, 2017; doi:10.1038/leu.2016.381; accepted article preview online December 23, 2016

The relationship between eligibility criteria and adverse events in randomized controlled trials of hematologic malignancies

A Statler, T Radivoyevitch, C Siebenaller, A T Gerds, M Kalaycio, E Kodish, S Mukherjee, C Cheng and M A Sekeres

Leukemia advance online publication, January 24, 2017; doi:10.1038/leu.2016.374; accepted article preview online December 7, 2016

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January 20 2017

Original Articles

Trends in overall survival and costs of multiple myeloma, 2000–2014 Open

R Fonseca, S Abouzaid, M Bonafede, Q Cai, K Parikh, L Cosler and P Richardson

Leukemia advance online publication, January 20, 2017; doi:10.1038/leu.2016.380; accepted article preview online December 23, 2016

IKZF1 expression is a prognostic marker in newly diagnosed standard-risk multiple myeloma treated with lenalidomide and intensive chemotherapy: a study of the German Myeloma Study Group (DSMM)

J Krönke, F Kuchenbauer, M Kull, V Teleanu, L Bullinger, D Bunjes, A Greiner, S Kolmus, S Köpff, M Schreder, L-O Mügge, C Straka, M Engelhardt, H Döhner, H Einsele, F Bassermann, R Bargou, S Knop and C Langer

Leukemia advance online publication, January 20, 2017; doi:10.1038/leu.2016.384; accepted article preview online December 26, 2016

PML-RARA-associated cooperating mutations belong to a transcriptional network that is deregulated in myeloid leukemias

C Ronchini, A Brozzi, L Riva, L Luzi, A M Gruszka, G E M Melloni, E Scanziani, G Dharmalingam, M Mutarelli, V Belcastro, S Lavorgna, V Rossi, O Spinelli, A Biondi, A Rambaldi, F Lo-Coco, D di Bernardo and P G Pelicci

Leukemia advance online publication, January 20, 2017; doi:10.1038/leu.2016.386; accepted article preview online December 27, 2016

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January 13 2017

Original Articles

A novel BCMA/CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo  Open

S Hipp, Y-T Tai, D Blanset, P Deegen, J Wahl, O Thomas, B Rattel, P J Adam, K C Anderson and M Friedrich

Leukemia advance online publication, January 13, 2017; doi:10.1038/leu.2016.388; accepted article preview online December 27, 2017

Extended time-lapse in vivo imaging of tibia bone marrow to visualize dynamic hematopoietic stem cell engraftment

S Kim, L Lin, G A J Brown, K Hosaka and E W Scott

Leukemia advance online publication, January 13, 2017; doi:10.1038/leu.2016.354; accepted article preview online November 28, 2016

p53 pathway dysfunction is highly prevalent in acute myeloid leukemia independent of TP53 mutational status

A Quintás-Cardama, C Hu, A Qutub, Y H Qiu, X Zhang, S M Post, N Zhang, K Coombes and S M Kornblau

Leukemia advance online publication, January 13, 2017; doi:10.1038/leu.2016.350; accepted article preview online November 25, 2016

Genome-wide association study of immunoglobulin light chain amyloidosis in three patient cohorts: comparison with myeloma

M I da Silva Filho, A Försti, N Weinhold, I Meziane, C Campo, S Huhn, J Nickel, P Hoffmann, M M Nöthen, K-H Jöckel, S Landi, J S Mitchell, D Johnson, G J Morgan, R Houlston, H Goldschmidt, A Jauch, P Milani, G Merlini, D Rowcieno, P Hawkins, U Hegenbart, G Palladini, A Wechalekar, S O Schönland and K Hemminki

Leukemia advance online publication, January 13, 2017; doi:10.1038/leu.2016.387; accepted article preview online December 27, 2016

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January 6 2017

Original Articles

Loss of p300 accelerates MDS-associated leukemogenesis

G Cheng, F Liu, T Asai, F Lai, N Man, H Xu, S Chen, S Greenblatt, P-J Hamard, K Ando, X Chen, L Wang, C Martinez, M Tadi, L Wang, M Xu, F-C Yang, R Shiekhattar and S D Nimer

Leukemia advance online publication, January 6, 2017; doi:10.1038/leu.2016.347; accepted article preview online November 24, 2016

Mutations in the CCND1 and CCND2 genes are frequent events in adult patients with t(8;21)(q22;q22) acute myeloid leukemia

A-K Eisfeld, J Kohlschmidt, S Schwind, D Nicolet, J S Blachly, S Orwick, C Shah, M Bainazar, K W Kroll, C J Walker, A J Carroll, B L Powell, R M Stone, J E Kolitz, M R Baer, A de la Chapelle, K Mrózek, J C Byrd and C D Bloomfield

Leukemia advance online publication, January 6, 2017; doi:10.1038/leu.2016.332; accepted article preview online November 15, 2016

Genomic and transcriptional landscape of P2RY8-CRLF2-positive childhood acute lymphoblastic leukemia Open

C Vesely, C Frech, C Eckert, G Cario, A Mecklenbräuker, U zur Stadt, K Nebral, F Kraler, S Fischer, A Attarbaschi, M Schuster, C Bock, H Cavé, A von Stackelberg, M Schrappe, M A Horstmann, G Mann, O A Haas and R Panzer-Grümayer

Leukemia advance online publication, January 6, 2017; doi:10.1038/leu.2016.365; accepted article preview online November 30, 2016

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January 3 2017

Original Articles

A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells Open

E J Cheadle, G Lipowska-Bhalla, S J Dovedi, E Fagnano, C Klein, J Honeychurch and T M Illidge

Leukemia advance online publication, January 3, 2017; doi:10.1038/leu.2016.352; accepted article preview online November 28, 2017

Complementary activities of DOT1L and Menin inhibitors in MLL-rearranged leukemia

C Dafflon, V J Craig, H Méreau, J Gräsel, B Schacher Engstler, G Hoffman, F Nigsch, S Gaulis, L Barys, M Ito, J Aguadé-Gorgorió, B Bornhauser, J-P Bourquin, A Proske, C Stork-Fux, M Murakami, W R Sellers, F Hofmann, J Schwaller and R Tiedt

Leukemia advance online publication, January 3, 2017; doi:10.1038/leu.2016.327; accepted article preview online November 14, 2016

IL-10 production by CLL cells is enhanced in the anergic IGHV mutated subset and associates with reduced DNA methylation of the IL10 locus

S Drennan, A D'Avola, Y Gao, C Weigel, E Chrysostomou, A J Steele, T Zenz, C Plass, P W Johnson, A P Williams, G Packham, F K Stevenson, C C Oakes and F Forconi

Leukemia advance online publication, January 3, 2017; doi:10.1038/leu.2016.356; accepted article preview online November 28, 2016

RPL5 on 1p22.1 is recurrently deleted in multiple myeloma and its expression is linked to bortezomib response

I J F Hofman, M van Duin, E De Bruyne, L Fancello, G Mulligan, E Geerdens, E Garelli, C Mancini, H Lemmens, M Delforge, P Vandenberghe, I Wlodarska, A Aspesi, L Michaux, K Vanderkerken, P Sonneveld and K De Keersmaecker

Leukemia advance online publication, January 3, 2017; doi:10.1038/leu.2016.370; accepted article preview online December 2, 2016

Inhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations

W Liu, W-M Yu, J Zhang, R J Chan, M L Loh, Z Zhang, K D Bunting and C-K Qu

Leukemia advance online publication, January 3, 2017; doi:10.1038/leu.2016.326; accepted article preview online November 14, 2016

Circulating tumour DNA analysis demonstrates spatial mutational heterogeneity that coincides with disease relapse in myeloma

S Mithraprabhu, T Khong, M Ramachandran, A Chow, D Klarica, L Mai, S Walsh, D Broemeling, A Marziali, M Wiggin, J Hocking, A Kalff, B Durie and A Spencer

Leukemia advance online publication, January 3, 2017; doi:10.1038/leu.2016.366; accepted article preview online November 30, 2016

Optimized T-cell receptor-mimic chimeric antigen receptor T cells directed toward the intracellular Wilms Tumor 1 antigen Open

S Rafiq, T J Purdon, A F Daniyan, M Koneru, T Dao, C Liu, D A Scheinberg and R J Brentjens

Leukemia advance online publication, January 3, 2017; doi:10.1038/leu.2016.373; accepted article preview online December 7, 2016

Inactivation of KLF4 promotes T-cell acute lymphoblastic leukemia and activates the MAP2K7 pathway

Y Shen, C S Park, K Suppipat, T-A Mistretta, M Puppi, T M Horton, K Rabin, N S Gray, J P P Meijerink and H D Lacorazza

Leukemia advance online publication, January 3, 2017; doi:10.1038/leu.2016.339; accepted article preview online November 22, 2016

Preclinical activity of CPI-0610, a novel small-molecule bromodomain and extra-terminal protein inhibitor in the therapy of multiple myeloma

K T Siu, J Ramachandran, A J Yee, H Eda, L Santo, C Panaroni, J A Mertz, R J Sims III, M R Cooper and N Raje

Leukemia advance online publication, January 3, 2017; doi:10.1038/leu.2016.355; accepted article preview online November 28, 2016

Acute myeloid leukemia derived from lympho-myeloid clonal hematopoiesis

F Thol, S Klesse, L Köhler, R Gabdoulline, A Kloos, A Liebich, M Wichmann, A Chaturvedi, J Fabisch, V I Gaidzik, P Paschka, L Bullinger, G Bug, H Serve, G Göhring, B Schlegelberger, M Lübbert, H Kirchner, M Wattad, D Kraemer, B Hertenstein, G Heil, W Fiedler, J Krauter, R F Schlenk, K Döhner, H Döhner, A Ganser and M Heuser

Leukemia advance online publication, January 3, 2017; doi:10.1038/leu.2016.345; accepted article preview online November 24, 2016

Restrictions in the T-cell repertoire of chronic lymphocytic leukemia: high-throughput immunoprofiling supports selection by shared antigenic elements

A Vardi, E Vlachonikola, M Karypidou, E Stalika, V Bikos, K Gemenetzi, C Maramis, A Siorenta, A Anagnostopoulos, S Pospisilova, N Maglaveras, I Chouvarda, K Stamatopoulos and A Hadzidimitriou

Leukemia advance online publication, January 3, 2017; doi:10.1038/leu.2016.362; accepted article preview online November 25, 2016

EGR2 mutations define a new clinically aggressive subgroup of chronic lymphocytic leukemia

E Young, D Noerenberg, L Mansouri, V Ljungström, M Frick, L-A Sutton, S J Blakemore, J Galan-Sousa, K Plevova, P Baliakas, D Rossi, R Clifford, D Roos-Weil, V Navrkalova, B Dörken, C A Schmitt, K E Smedby, G Juliusson, B Giacopelli, J S Blachly, C Belessi, P Panagiotidis, N Chiorazzi, F Davi, A W Langerak, D Oscier, A Schuh, G Gaidano, P Ghia, W Xu, L Fan, O A Bernard, F Nguyen-Khac, L Rassenti, J Li, T J Kipps, K Stamatopoulos, S Pospisilova, T Zenz, C C Oakes, J C Strefford, R Rosenquist and F Damm

Leukemia advance online publication, January 3, 2017; doi:10.1038/leu.2016.359; accepted article preview online November 28, 2016

Cirmtuzumab inhibits Wnt5a-induced Rac1 activation in chronic lymphocytic leukemia treated with ibrutinib Open

J Yu, L Chen, B Cui, Christina Wu, M Y Choi, Y Chen, L Zhang, L Z Rassenti, G F Widhopf II and T J Kipps

Leukemia advance online publication, January 3, 2017; doi:10.1038/leu.2016.368; accepted article preview online December 1, 2016

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December 20 2016

Original Articles

Genetic characterization of MYD88-mutated lymphoplasmacytic lymphoma in comparison with MYD88-mutated chronic lymphocytic leukemia

C Baer, F Dicker, W Kern, T Haferlach and C Haferlach

Leukemia advance online publication, December 20, 2016; doi:10.1038/leu.2016.330; accepted article preview online November 14, 2016

PI3Kδ inhibition elicits anti-leukemic effects through Bim-dependent apoptosis Open

M J Carter, K L Cox, S J Blakemore, A H Turaj, R J Oldham, L N Dahal, S Tannheimer, F Forconi, G Packham and M S Cragg

Leukemia advance online publication, December 20, 2016; doi:10.1038/leu.2016.333; accepted article preview online November 15, 2016

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December 16 2016

Original Articles

Histone deacetylase inhibitors interrupt HSP90•RASGRP1 and HSP90•CRAF interactions to upregulate BIM and circumvent drug resistance in lymphoma cells

H Ding, K L Peterson, C Correia, B Koh, P A Schneider, G S Nowakowski and S H Kaufmann

Leukemia advance online publication, December 16, 2016; doi:10.1038/leu.2016.357; accepted article preview online November 28, 2016

The AP-1 transcription factor JunB is essential for multiple myeloma cell proliferation and drug resistance in the bone marrow microenvironment

F Fan, M H Bashari, E Morelli, G Tonon, S Malvestiti, S Vallet, M Jarahian, A Seckinger, D Hose, L Bakiri, C Sun, Y Hu, C R Ball, H Glimm, M Sattler, H Goldschmidt, E F Wagner, P Tassone, D Jaeger and K Podar

Leukemia advance online publication, December 16, 2016; doi:10.1038/leu.2016.358; accepted article preview online November 28, 2016

Interphase fluorescence in situ hybridization in untreated AL amyloidosis has an independent prognostic impact by abnormality type and treatment category

E Muchtar, A Dispenzieri, S K Kumar, R P Ketterling, D Dingli, M Q Lacy, F K Buadi, S R Hayman, P Kapoor, N Leung, R Chakraborty, W Gonsalves, R Warsame, T V Kourelis, S Russell, J A Lust, Y Lin, R S Go, S Zeldenrust, R A Kyle, S V Rajkumar and M A Gertz

Leukemia advance online publication, December 16, 2016; doi:10.1038/leu.2016.369; accepted article preview online December 1, 2016

Casein kinase 2 controls the survival of normal thymic and leukemic γδ T cells via promotion of AKT signaling Open

S T Ribeiro, M Tesio, J C Ribot, E Macintyre, J T Barata and B Silva-Santos

Leukemia advance online publication, December 16, 2016; doi:10.1038/leu.2016.363; accepted article preview online November 30, 2016

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December 9 2016

Original Article

In vitro and in vivo assessment of direct effects of simulated solar and galactic cosmic radiation on human hematopoietic stem/progenitor cells

C Rodman, G Almeida-Porada, S K George, J Moon, S Soker, T Pardee, M Beaty, P Guida, S P Sajuthi, C D Langefeld, S J Walker, P F Wilson and C D Porada

Leukemia advance online publication, December 9, 2016; doi:10.1038/leu.2016.344; accepted article preview online November 24, 2016

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December 2 2016

Original Article

Fatty acid-binding protein FABP4 mechanistically links obesity with aggressive AML by enhancing aberrant DNA methylation in AML cells

F Yan, N Shen, J X Pang, Y W Zhang, E Y Rao, A M Bode, A Al-Kali, D E Zhang, M R Litzow, B Li and S J Liu

Leukemia advance online publication, December 2, 2016; doi:10.1038/leu.2016.349; accepted article preview online November 25, 2016

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