ADVANCE ONLINE PUBLICATION
The latest research papers, published online ahead of print. These online versions are definitive and may be cited using the digital object identifier (DOI).
About advance online publication
July 17 2008 |
July 10 2008 |
July 3 2008 |
June 26 2008 |
June 19 2008 |
June 12 2008 |
June 5 2008 |
May 29 2008 |
May 22 2008 |
May 15 2008 |
May 8 2008 |
May 1 2008 |
April 24 2008 |
April 17 2008 |
April 10 2008 |
April 3 2008 |
March 27 2008 |
March 20 2008 |
March 13 2008 |
March 6 2008 |
February 28 2008 |
February 14 2008 |
February 7 2008
July 24 2008
Original Articles
Leukemia suppressor function of Egr-1 is dependent on transforming oncogene
J D Gibbs, D A Liebermann and B Hoffman
Leukemia advance online publication, July 24, 2008; doi:10.1038/leu.2008.189
c-Jun N-terminal kinase activation failure is a new mechanism of anthracycline resistance in acute myeloid leukemia
E D Lagadinou, P G Ziros, O A Tsopra, K Dimas, D Kokkinou, E Thanopoulou, M Karakantza, P Pantazis, A Spyridonidis and N C Zoumbos
Leukemia advance online publication, July 24, 2008; doi:10.1038/leu.2008.192
July 17 2008
Original Articles
A novel arsenical has antitumor activity toward As2O3-resistant and MRP1/ABCC1-overexpressing cell lines
Z Diaz, K K Mann, S Marcoux, M Kourelis, M Colombo, P B Komarnitsky and W H Miller Jr
Leukemia advance online publication, July 17, 2008; doi:10.1038/leu.2008.194
High-resolution analysis of chromosome copy number alterations in angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, unspecified, with single nucleotide polymorphism-typing microarrays
S-i Fujiwara, Y Yamashita, N Nakamura, Y L Choi, T Ueno, H Watanabe, K Kurashina, M Soda, M Enomoto, H Hatanaka, S Takada, M Abe, K Ozawa and H Mano
Leukemia advance online publication, July 17, 2008; doi:10.1038/leu.2008.191
Ex vivo priming of CD4 T cells converts immunological tolerance into effective antitumor immunity in a murine model of acute lymphoblastic leukemia
A N Hegazy and C Klein
Leukemia advance online publication, July 17, 2008; doi:10.1038/leu.2008.193
Doubling time of soluble CD23: a powerful prognostic factor for newly diagnosed and untreated stage A chronic lymphocytic leukemia patients
N Meuleman, B Stamatopoulos, M Dejeneffe, H El Housni, L Lagneaux and D Bron
Leukemia advance online publication, July 17, 2008; doi:10.1038/leu.2008.190
Letter to the Editor
Rapid diagnosis of ataxia-telangiectasia by flow cytometric monitoring of DNA damage-dependent ATM phosphorylation
M Honda, M Takagi, L Chessa, T Morio and S Mizuatni
Leukemia advance online publication, July 17, 2008; doi:10.1038/leu.2008.195
July 10 2008
Original Articles
Spontaneous and Fas-induced apoptosis of low-grade MDS erythroid precursors involves the endoplasmic reticulum
E Gyan, E Frisan, O Beyne-Rauzy, J-C Deschemin, C Pierre-Eugene, C Randriamampita, A Dubart-Kupperschmitt, C Garrido, F Dreyfus, P Mayeux, C Lacombe, E Solary and M Fontenay
Leukemia advance online publication, July 10, 2008; doi:10.1038/leu.2008.172
The expression of 16 genes related to the cell of origin and immune response predicts survival in elderly patients with diffuse large B-cell lymphoma treated with CHOP and rituximab
J-P Jais, C Haioun, T J Molina, D S Rickman, A de Reynies, F Berger, C Gisselbrecht, J Brière, F Reyes, P Gaulard, P Feugier, E Labouyrie, H Tilly, C Bastard, B Coiffier, G Salles and K Leroy
Leukemia advance online publication, July 10, 2008; doi:10.1038/leu.2008.188
Letters to the Editor
Combining SDF-1/CXCR4 antagonism and chemotherapy in relapsed acute myeloid leukemia
F A Fierro, S Brenner, U Oelschlaegel, A Jacobi, H Knoth, G Ehninger, T Illmer and M Bornhäuser
Leukemia advance online publication, July 10, 2008; doi:10.1038/leu.2008.182
Coding polymorphisms in CD33 and response to gemtuzumab ozogamicin in pediatric patients with AML: a pilot study
J K Lamba, S Pounds, X Cao, J R Downing, D Campana, R C Ribeiro, C-H Pui and J E Rubnitz
Leukemia advance online publication, July 10, 2008; doi:10.1038/leu.2008.185
Dic(9;20)(p13;q11) in childhood acute lymphoblastic leukaemia is related to low cellular resistance to asparaginase, cytarabine and corticosteroids
G Lönnerholm, A Nordgren, B-M Frost, O G Jonsson, J Kanerva, R Nygaard, K Schmiegelow, R Larsson and E Forestier
Leukemia advance online publication, July 10, 2008; doi:10.1038/leu.2008.179
Kinetics of humoral response to ALK and its relationship with minimal residual disease in pediatric ALCL
L Mussolin, P Bonvini, K Ait-Tahar, M Pillon, G Tridello, S Buffardi, A Lombardi, K Pulford and A Rosolen
Leukemia advance online publication, July 10, 2008; doi:10.1038/leu.2008.184
Absolute quantitative detection of ABL tyrosine kinase domain point mutations in chronic myeloid leukemia using a novel nanofluidic platform and mutation-specific PCR
V G Oehler, J Qin, R Ramakrishnan, G Facer, S Ananthnarayan, C Cummings, M Deininger, N Shah, F McCormick, S Willis, A Daridon, M Unger and J P Radich
Leukemia advance online publication, July 10, 2008; doi:10.1038/leu.2008.183
Highly sensitive and quantitative detection of BCR-ABL kinase domain mutations by ligation PCR
O Pelz-Ackermann, M Cross, H Pfeifer, M Deininger, S-Y Wang, H K Al-Ali, D Niederwieser and T Lange
Leukemia advance online publication, July 10, 2008; doi:10.1038/leu.2008.180
High-throughput mutational screen of the tyrosine kinome in chronic myelomonocytic leukemia
J W Tyner, M M Loriaux, H Erickson, C A Eide, J Deininger, M MacPartlin, S G Willis, T Lange, B J Druker, T Kovacsovics, R Maziarz, N Gattermann and M W Deininger
Leukemia advance online publication, July 10, 2008; doi:10.1038/leu.2008.187
July 3 2008
Spotlight Review
Evidence and expertise in the management of polycythemia vera and essential thrombocythemia
G Finazzi and T Barbui
Leukemia advance online publication, July 3, 2008; doi:10.1038/leu.2008.177
Original Articles
Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma
I Breitkreutz, M S Raab, S Vallet, T Hideshima, N Raje, C Mitsiades, D Chauhan, Y Okawa, N C Munshi, P G Richardson and K C Anderson
Leukemia advance online publication, July 3, 2008; doi:10.1038/leu.2008.174
BCL-2 phosphorylation modulates sensitivity to the BH3 mimetic GX15-070 (Obatoclax) and reduces its synergistic interaction with bortezomib in chronic lymphocytic leukemia cells
P Pérez-Galán, G Roué, M López-Guerra, M Nguyen, N Villamor, E Montserrat, G C Shore, E Campo and D Colomer
Leukemia advance online publication, July 3, 2008; doi:10.1038/leu.2008.175
Prognostic value of the serum free light chain ratio in newly diagnosed myeloma: proposed incorporation into the international staging system
C L H Snozek, J A Katzmann, R A Kyle, A Dispenzieri, D R Larson, T M Therneau, L J Melton III, S Kumar, P R Greipp, R J Clark and S V Rajkumar
Leukemia advance online publication, July 3, 2008; doi:10.1038/leu.2008.171
Tyrosine kinase inhibition in diffuse large B-cell lymphoma: molecular basis for antitumor activity and drug resistance of dasatinib
C Yang, P Lu, F Y Lee, A Chadburn, J C Barrientos, J P Leonard, F Ye, D Zhang, D M Knowles and Y L Wang
Leukemia advance online publication, July 3, 2008; doi:10.1038/leu.2008.163
Letters to the Editor
Preferential sensitivity of hematopoietic (HPs) and mesenchymal (MPs) progenitors to fludarabine suggests impaired bone marrow niche and HP mobilization
M G Berger, J Berger, C Richard, S Jeanpierre, F E Nicolini, O Tournilhac, M Michallet and V M Satta
Leukemia advance online publication, July 3, 2008; doi:10.1038/leu.2008.167
TP53 gene mutation is frequent in patients with acute myeloid leukemia and complex karyotype, and is associated with very poor prognosis
D Bowen, M J Groves, A K Burnett, Y Patel, C Allen, C Green, R E Gale, R Hills and D C Linch
Leukemia advance online publication, July 3, 2008; doi:10.1038/leu.2008.173
Interleukin-4 stimulates proliferation and growth of T-cell acute lymphoblastic leukemia cells by activating mTOR signaling
B A Cardoso, L R Martins, C I Santos, L M Nadler, V A Boussiotis, A A Cardoso and J T Barata
Leukemia advance online publication, July 3, 2008; doi:10.1038/leu.2008.178
Simultaneous occurrence of acute myeloid leukaemia with mutated nucleophosmin (NPM1) in the same family
G Cazzaniga, L Lo Nigro, I Cifola, G Milone, S Schnittger, T Haferlach, E Mirabile, F Costantino, M P Martelli, E Mastrodicasa, F Di Raimondo, F Aversa, A Biondi and B Falini
Leukemia advance online publication, July 3, 2008; doi:10.1038/leu.2008.170
Prior treatment with the tyrosine kinase inhibitors dasatinib and nilotinib allows stem cell transplantation (SCT) in a less advanced disease phase and does not increase SCT Toxicity in patients with chronic myelogenous leukemia and philadelphia positive acute lymphoblastic leukemia
A Shimoni, M Leiba, M Schleuning, G Martineau, M Renaud, M Koren-Michowitz, E Ribakovski, P le Coutre, R Arnold, F Guilhot and A Nagler
Leukemia advance online publication, July 3, 2008; doi:10.1038/leu.2008.160
Decreased IRF8 expression found in aging hematopoietic progenitor/stem cells
D L Stirewalt, Y E Choi, N E Sharpless, E L Pogosova-Agadjanyan, M R Cronk, M Yukawa, E B Larson, B L Wood, F R Appelbaum, J P Radich and S Heimfeld
Leukemia advance online publication, July 3, 2008; doi:10.1038/leu.2008.176
June 26 2008
Original Articles
Pharmacokinetic, pharmacodynamic and intracellular effects of PEG-asparaginase in newly diagnosed childhood acute lymphoblastic leukemia: results from a single agent window study
I M Appel, K M Kazemier, J Boos, C Lanvers, J Huijmans, A J P Veerman, E van Wering, M L den Boer and R Pieters
Leukemia advance online publication, June 26, 2008; doi:10.1038/leu.2008.165
Pathway activation patterns in diffuse large B-cell lymphomas
S Bentink, S Wessendorf, C Schwaenen, M Rosolowski, W Klapper, A Rosenwald, G Ott, A H Banham, H Berger, A C Feller, M-L Hansmann, D Hasenclever, M Hummel, D Lenze, P Möller, B Stuerzenhofecker, M Loeffler, L Truemper, H Stein, R Siebert and R Spang
Leukemia advance online publication, June 26, 2008; doi:10.1038/leu.2008.166
Incorporation of the bone marker carboxy-terminal telopeptide of type-1 collagen improves prognostic information of the International Staging System in newly diagnosed symptomatic multiple myeloma
C Jakob, J Sterz, P Liebisch, M Mieth, J Rademacher, A Goerke, U Heider, C Fleissner, M Kaiser, I von Metzler, C Müller and O Sezer
Leukemia advance online publication, June 26, 2008; doi:10.1038/leu.2008.159
Prognostic role of glutathione S-transferase polymorphisms in acute myeloid leukemia
M T Voso, S Hohaus, F Guidi, E Fabiani, F D'Alo', S Groner, D Späth, K Doehner, G Leone, H Doehner and R F Schlenk
Leukemia advance online publication, June 26, 2008; doi:10.1038/leu.2008.169
Letters to the Editor
Molecular insights into the morphology of myeloproliferative neoplasms using an in situ PCR assay specific for the JAK2 mutation V617F
S Gattenlohner, E Serfling, H Einsele and H K Müller-Hermelink
Leukemia advance online publication, June 26, 2008; doi:10.1038/leu.2008.168
Reduced intensity conditioning allogeneic stem cell transplantation for patients with acute myeloid leukemia: long term results of a 'donor' versus 'no donor' comparison
M Mohty, H de Lavallade, J El-Cheikh, P Ladaique, C Faucher, S Fürst, N Vey, D Coso, A-M Stoppa, J-A Gastaut, C Chabannon and D Blaise
Leukemia advance online publication, June 26, 2008; doi:10.1038/leu.2008.164
June 19 2008
Review
Immunotherapy for myeloid leukemias: current status and future directions
K el-Shami and B D Smith
Leukemia advance online publication, June 19, 2008; doi:10.1038/leu.2008.148
Letters to the Editor
Large interindividual differences in cellular sensitivity to calicheamicin may influence gemtuzumab ozogamicin response in acute myeloid leukemia
B F Goemans, C M Zwaan, S J H Vijverberg, A H Loonen, U Creutzig, K Hählen, D Reinhardt, B E S Gibson, J Cloos and G J L Kaspers
Leukemia advance online publication, June 19, 2008; doi:10.1038/leu.2008.147
A western blot assay for detecting mutant nucleophosmin (NPM1) proteins in acute myeloid leukaemia
M P Martelli, N Manes, A Liso, V Pettirossi, B Verducci Galletti, B Bigerna, A Pucciarini, M F De Marco, M T Pallotta, N Bolli, M Sborgia, F di Raimondo, F Fabbiano, G Meloni, G Specchia, M F Martelli and B Falini
Leukemia advance online publication, June 19, 2008; doi:10.1038/leu.2008.149
June 12 2008
Review
Epigenetic plasticity of chromatin in embryonic and hematopoietic stem/progenitor cells: therapeutic potential of cell reprogramming
G Zardo, G Cimino and C Nervi
Leukemia advance online publication, June 12, 2008; doi:10.1038/leu.2008.141
Original Articles
On the use of lonafarnib in myelodysplastic syndrome and chronic myelomonocytic leukemia
E J Feldman, J Cortes, D J DeAngelo, T Holyoake, B Simonsson, S G O'Brien, J Reiffers, A R Turner, G J Roboz, J H Lipton, F Maloisel, P Colombat, G Martinelli, J L Nielsen, S Petersdorf, F Guilhot, J Barker, P Kirschmeier, E Frank, P Statkevich, Y Zhu, S Loechner and A List
Leukemia advance online publication, June 12, 2008; doi:10.1038/leu.2008.156
A pilot pharmacokinetic study of oral azacitidine
G Garcia-Manero, M L Stoltz, M R Ward, H Kantarjian and S Sharma
Leukemia advance online publication, June 12, 2008; doi:10.1038/leu.2008.145
Prenatal origin of childhood acute lymphoblastic leukemia, association with birth weight and hyperdiploidy
B Gruhn, J W Taub, Y Ge, J F Beck, R Zell, R Häfer, F H Hermann, K-M Debatin and D Steinbach
Leukemia advance online publication, June 12, 2008; doi:10.1038/leu.2008.152
The dual PI3 kinase/mTOR inhibitor PI-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML
K Kojima, M Shimanuki, M Shikami, I J Samudio, V Ruvolo, P Corn, N Hanaoka, M Konopleva, M Andreeff and H Nakakuma
Leukemia advance online publication, June 12, 2008; doi:10.1038/leu.2008.158
PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML
S Park, N Chapuis, V Bardet, J Tamburini, N Gallay, L Willems, Z A Knight, K M Shokat, N Azar, F Viguié, N Ifrah, F Dreyfus, P Mayeux, C Lacombe and D Bouscary
Leukemia advance online publication, June 12, 2008; doi:10.1038/leu.2008.144
Spongistatin 1: a new chemosensitizing marine compound that degrades XIAP
L Schyschka, A Rudy, I Jeremias, N Barth, G R Pettit and A M Vollmar
Leukemia advance online publication, June 12, 2008; doi:10.1038/leu.2008.146
Hematopoietic stem cells and progenitors of chronic myeloid leukemia express leukemia-associated antigens: implications for the graft-versus-leukemia effect and peptide vaccine-based immunotherapy
A S M Yong, K Keyvanfar, R Eniafe, B N Savani, K Rezvani, E M Sloand, J M Goldman and A J Barrett
Leukemia advance online publication, June 12, 2008; doi:10.1038/leu.2008.161
Letters to the Editor
Reply to 'The correlation between cotransplantation of mesenchymal stem cells and higher recurrence rates in hematologic malignancy patients: outcome of a pilot clinical study' by Ning et al.
G Behre, S Theurich, T Weber and M Christopeit
Leukemia advance online publication, June 12, 2008; doi:10.1038/leu.2008.150
MicroRNAs and deletion of the derivative chromosome 9 in chronic myeloid leukemia
A Chaubey, S Karanti, D Rai, T Oh, S G Adhvaryu and R C T Aguiar
Leukemia advance online publication, June 12, 2008; doi:10.1038/leu.2008.154
In reply to 'Improving the prognostic evaluation of patients with lower-risk myelodysplastic syndromes' by Kuendgen et al.
G Garcia-Manero
Leukemia advance online publication, June 12, 2008; doi:10.1038/leu.2008.155
Novel gain-of-function mutation in the extracellular domain of the PDGFRA gene in infant acute lymphoblastic leukemia with t(4;11)(q21;q23)
M Hiwatari, R Ono, T Taki, A Hishiya, E Ishii, T Kitamura, Y Hayashi and T Nosaka
Leukemia advance online publication, June 12, 2008; doi:10.1038/leu.2008.140
Improving the prognostic evaluation of patients with lower risk myelodysplastic syndromes
A Kuendgen, N Gattermann and U Germing
Leukemia advance online publication, June 12, 2008; doi:10.1038/leu.2008.153
Reply to "Reply to 'The correlation between cotransplantation of mesenchymal stem cells and higher recurrence rates in hematologic malignancy patients: outcome of a pilot clinical study' by Ning H et al." by Behre et al.
H Ning, F Yang, M Jiang, L Hu, K Feng, J Zhang, Z Yu, B Li, C Xu, Y Li, J Wang, J Hu, X Lou and H Chen
Leukemia advance online publication, June 12, 2008; doi:10.1038/leu.2008.151
Transient depletion of RUNX1/RUNX1T1 by RNA interference delays tumour formation in vivo
N Martinez Soria, R Tussiwand, P Ziegler, M G Manz and O Heidenreich
Leukemia advance online publication, June 12, 2008; doi:10.1038/leu.2008.157
June 5 2008
Spotlight Review
Pathogenesis and treatment of renal failure in multiple myeloma
M A Dimopoulos, E Kastritis, L Rosinol, J Bladé and H Ludwig
Leukemia advance online publication, June 5, 2008; doi:10.1038/leu.2008.131
Original Articles
New mutations of MPL in primitive myelofibrosis: only the MPL W515 mutations promote a G1/S-phase transition
R Chaligné, C Tonetti, R Besancenot, L Roy, C Marty, P Mossuz, J-J Kiladjian, G Socié, D Bordessoule, M-C Le Bousse-Kerdilès, W Vainchenker and S Giraudier
Leukemia advance online publication, June 5, 2008; doi:10.1038/leu.2008.137
Acute myeloid leukaemia with 8p11 (MYST3) rearrangement: an integrated cytologic, cytogenetic and molecular study by the groupe francophone de cytogénétique hématologique
C Gervais, A Murati, C Helias, S Struski, A Eischen, E Lippert, I Tigaud, D Penther, C Bastard, F Mugneret, B Poppe, F Speleman, P Talmant, J VanDen Akker, L Baranger, C Barin, I Luquet, N Nadal, F Nguyen-Khac, O Maarek, C Herens, D Sainty, G Flandrin, D Birnbaum, M-J Mozziconacci and M Lessard
Leukemia advance online publication, June 5, 2008; doi:10.1038/leu.2008.128
Mutations of the TP53 gene in acute myeloid leukemia are strongly associated with a complex aberrant karyotype
C Haferlach, F Dicker, H Herholz, S Schnittger, W Kern and T Haferlach
Leukemia advance online publication, June 5, 2008; doi:10.1038/leu.2008.143
Genome-wide identification of aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia
S-Q Kuang, W-G Tong, H Yang, W Lin, M K Lee, Z H Fang, Y Wei, J Jelinek, J-P Issa and G Garcia-Manero
Leukemia advance online publication, June 5, 2008; doi:10.1038/leu.2008.130
Letters to the Editor
Clinical and biological significance of RAS mutations in multiple myeloma
W J Chng, N Gonzalez-Paz, T Price-Troska, S Jacobus, S V Rajkumar, M M Oken, R A Kyle, K J Henderson, S Van Wier, P Greipp, B Van Ness and R Fonseca
Leukemia advance online publication, June 5, 2008; doi:10.1038/leu.2008.142
Cotransplantation of mesenchymal cells and a higher relapse rate: a role for HLA-G molecules?
R Rizzo, D Campioni, F Lanza and O R Baricordi
Leukemia advance online publication, June 5, 2008; doi:10.1038/leu.2008.135
Notch inhibition blocks multiple myeloma cell-induced osteoclast activation
R Schwarzer, M Kaiser, O Acikgoez, U Heider, S Mathas, R Preissner, O Sezer, B Doerken and F Jundt
Leukemia advance online publication, June 5, 2008; doi:10.1038/leu.2008.138
Spurious elevation of the cerebrospinous fluid white cell counts in three patients receiving liposomal cytarabine as part of post-remission therapy
R Swords, C O'Rafferty, F Giles and P Browne
Leukemia advance online publication, June 5, 2008; doi:10.1038/leu.2008.139
May 29 2008
Original Article
Aberrant expression of IL-22 receptor 1 and autocrine IL-22 stimulation contribute to tumorigenicity in ALK+ anaplastic large cell lymphoma
J Dien Bard, P Gelebart, M Anand, H M Amin and R Lai
Leukemia advance online publication, May 29, 2008; doi:10.1038/leu.2008.129
Letters to the Editor
An activating KRAS mutation in imatinib-resistant chronic myeloid leukemia
A Agarwal, C A Eide, A Harlow, A S Corbin, M J Mauro, B J Druker, C L Corless, M C Heinrich and M W Deininger
Leukemia advance online publication, May 29, 2008; doi:10.1038/leu.2008.124
Oncolytic virotherapy for multiple myeloma using a tumour-specific double-deleted vaccinia virus
H Deng, N Tang, A E Stief, N Mehta, E Baig, R Head, G Sleep, X-Z Yang, C McKerlie, S Trudel, A K Stewart and J A McCart
Leukemia advance online publication, May 29, 2008; doi:10.1038/leu.2008.120
5-Azacitidine has limited therapeutic activity in myelofibrosis
R A Mesa, S Verstovsek, C Rivera, A Pardanani, K Hussein, T Lasho, W Wu and A Tefferi
Leukemia advance online publication, May 29, 2008; doi:10.1038/leu.2008.136
Keynote Address
The role of vertebral augmentation in multiple myeloma: International Myeloma Working Group Consensus Statement
M A Hussein, F D Vrionis, R Allison, J Berenson, S Berven, E Erdem, S Giralt, S Jagannath, R A Kyle, S LeGrand, R Pflugmacher, N Raje, S V Rajkumar, L Randall, D Roodman, D Siegel, R Vescio, J Zonder and B G M Durie
Leukemia advance online publication, May 29, 2008; doi:10.1038/leu.2008.127
May 22 2008
Original Articles
Familial essential thrombocythemia with spontaneous megakaryocyte colony formation and acquired JAK2 mutations
J R Higgs, I Sadek, P E Neumann, V W Ing, N K Renault, J N Berman and W L Greer
Leukemia advance online publication, May 22, 2008; doi:10.1038/leu.2008.115
Leukemia induction after a single retroviral vector insertion in Evi1 or Prdm16
U Modlich, A Schambach, M H Brugman, D C Wicke, S Knoess, Z Li, T Maetzig, C Rudolph, B Schlegelberger and C Baum
Leukemia advance online publication, May 22, 2008; doi:10.1038/leu.2008.118
Identification of NM23-H2 as a tumour-associated antigen in chronic myeloid leukaemia
S Tschiedel, C Gentilini, T Lange, C Wölfel, T Wölfel, V Lennerz, S Stevanovic, H-G Rammensee, C Huber, M Cross and D Niederwieser
Leukemia advance online publication, May 22, 2008; doi:10.1038/leu.2008.107
Letters to the Editor
PKR is activated in MDS patients and its subcellular localization depends on disease severity
M Y Follo, C Finelli, S Mongiorgi, C Clissa, C Bosi, G Martinelli, W L Blalock, L Cocco and A M Martelli
Leukemia advance online publication, May 22, 2008; doi:10.1038/leu.2008.122
Improving minimal residual disease detection in precursor B-ALL based on immunoglobulin-
and heavy-chain gene rearrangements
R Sutton, A Y Bahar, E Kwan, J E Giles, N C Venn, S Tran, N Hackenberg, L Dalla Pozza, G M Marshall, M Haber, V H J van der Velden and M D Norris
Leukemia advance online publication, May 22, 2008; doi:10.1038/leu.2008.121
May 15 2008
Original Article
Signalling profile and antitumour activity of the novel Hsp90 inhibitor NVP-AUY922 in multiple myeloma
T Stühmer, A Zöllinger, D Siegmund, M Chatterjee, E Grella, S Knop, M Kortüm, C Unzicker, M R Jensen, C Quadt, P Chène, J Schoepfer, C García-Echeverría, H Einsele, H Wajant and R C Bargou
Leukemia advance online publication, May 15, 2008; doi:10.1038/leu.2008.111
Letters to the Editor
Claimed association of absolute lymphocyte count with therapeutic efficacy of radio-immunotherapy in patients with indolent lymphoma cannot be verified in an independent data set
M J Bishton, R J Hicks, H M Prince, D S Ritchie, M Wolf and J F Seymour
Leukemia advance online publication, May 15, 2008; doi:10.1038/leu.2008.116
Reply to 'Claimed association of absolute lymphocyte count with therapeutic efficacy of radio-immunotherapy in patients with indolent lymphoma cannot be verified in an independence data set' by Mark J Bishton et al
L F Porrata, K Ristow, T E Witzig, N Tuinistra, T M Habermann, D J Inwards, S M Ansell, I N Micallef, P B Johnston and S N Markovic
Leukemia advance online publication, May 15, 2008; doi:10.1038/leu.2008.117
How little is too much? p53 inactivation: from laboratory cutoff to biological basis of chemotherapy resistance
T Zenz, S Häbe, T Denzel, D Winkler, H Döhner and S Stilgenbauer
Leukemia advance online publication, May 15, 2008; doi:10.1038/leu.2008.114
May 8 2008
Original Article
Intracellular ABC transporter A3 confers multidrug resistance in leukemia cells by lysosomal drug sequestration
B Chapuy, R Koch, U Radunski, S Corsham, N Cheong, N Inagaki, N Ban, D Wenzel, D Reinhardt, A Zapf, S Schweyer, F Kosari, W Klapper, L Truemper and G G Wulf
Leukemia advance online publication, May 8, 2008; doi:10.1038/leu.2008.103
Letters to the Editor
Gynecomastia in a male after dasatinib treatment for chronic myeloid leukemia
G Caocci, S Atzeni, N Orrù, L Azzena, L Martorana, R Littera, A Ledda and G La Nasa
Leukemia advance online publication, May 8, 2008; doi:10.1038/leu.2008.106
Association of KIR2DS4 and its variant KIR1D with leukemia
S Giebel, I Nowak, J Wojnar, M Krawczyk-Kulis, J Holowiecki, S Kyrcz-Krzemien and P Kusnierczyk
Leukemia advance online publication, May 8, 2008; doi:10.1038/leu.2008.108
Reply to Verheyden and Demanet
S Giebel, I Nowak, E Majorczyk and P Kusnierczyk
Leukemia advance online publication, May 8, 2008; doi:10.1038/leu.2008.110
Reply to: Association of KIR2DS4 and its variant KIR1D with leukemia
S Verheyden and C Demanet
Leukemia advance online publication, May 8, 2008; doi:10.1038/leu.2008.109
May 1 2008
Original Article
Aberrant expression of Notch1 interferes with the B-lymphoid phenotype of neoplastic B cells in classical Hodgkin lymphoma
F Jundt, Ö Acikgöz, S-H Kwon, R Schwarzer, I Anagnostopoulos, B Wiesner, S Mathas, M Hummel, H Stein, H M Reichardt and B Dörken
Leukemia advance online publication, May 1, 2008; doi:10.1038/leu.2008.101
Letters to the Editor
The most frequent t(14;19)(q32;q13)-positive B-cell malignancy corresponds to an aggressive subgroup of atypical chronic lymphocytic leukemia
E Chapiro, I Radford-Weiss, C Bastard, I Luquet, C Lefebvre, E Callet-Bauchu, D Leroux, P Talmant, M-J Mozziconacci, F Mugneret, S Struski, S Raynaud, J Andrieux, C Barin, M Jotterand, H Mossafa, S Ramond, C Terré, E Lippert, F Berger, P Felman, H Merle-Béral, O A Bernard, F Davi, R Berger and F Nguyen-Khac
Leukemia advance online publication, May 1, 2008; doi:10.1038/leu.2008.102
Genomic typing for patient-specific human leukocyte antigen-alleles is an efficient tool for relapse detection of high-risk hematopoietic malignancies after stem cell transplantation from alternative donors
B Mazzi, T D Clerici, M Zanussi, M T Lupo Stanghellini, L Vago, E Sironi, J Peccatori, M Bernardi, P Carrera, A Palini, S Rossini, C Bordignon, C Bonini, M Ferrari, F Ciceri and K Fleischhauer
Leukemia advance online publication, May 1, 2008; doi:10.1038/leu.2008.98
Corticosteroids in the prevention of graft-vs-host disease after allogeneic myeloablative stem cell transplantation: a systematic review and meta-analysis
S Quellmann, G Schwarzer, K Hübel, A Engert and J Bohlius
Leukemia advance online publication, May 1, 2008; doi:10.1038/leu.2008.105
Successful treatment of multicentric Castleman's disease with combined immunochemotherapy in an AIDS patient with multiorgan failure
S M Schmidt, A Raible, F Kortüm, F Mayer, R Riessen, P Adam, M Gregor and A L Bissinger
Leukemia advance online publication, May 1, 2008; doi:10.1038/leu.2008.54
In-vivo detectable antibodies directed against the oncofetal antigen/immature laminin receptor can recognize and control myeloma cells—clinical implications
S Siegel, B Friedrichs, A-K Budde, A Barsoum, J Coggin Jr, M Tiemann, D Kabelitz and M Zeis
Leukemia advance online publication, May 1, 2008; doi:10.1038/leu.2008.92
April 24 2008
Letter to the Editor
Quantitative monitoring of cell clones carrying point mutations in the BCR–ABL tyrosine kinase domain by ligation-dependent polymerase chain reaction (LD–PCR)
S Preuner, D Denk, F Frommlet, M Nesslboeck and T Lion
Leukemia advance online publication, April 24, 2008; doi:10.1038/leu.2008.97
April 17 2008
Letters to the Editor
Amonafide L-malate is not a substrate for multidrug resistance proteins in secondary acute myeloid leukemia
M Burcu, K L O'Loughlin, L A Ford and M R Baer
Leukemia advance online publication, April 17, 2008; doi:10.1038/leu.2008.87
The WHO 2008 classification of Ph-myeloproliferative disorders: statement of the Czech MPD Working Group
J Schwarz, M Penka, K Indrák, D Pospí
ilová, R Pytlík, P Dulí
ek, M Doubek, L K
en and V Campr
Leukemia advance online publication, April 17, 2008; doi:10.1038/leu.2008.93
April 10 2008
Letters to the Editor
Natural T-cell responses against minor histocompatibility antigen (mHag) HY following HLA-matched hematopoietic cell transplantation: what are the requirements for a 'good' mHag?
T Kollgaard, S Reker Hadrup, S L Petersen, T N Masmas, M H Andersen, E Spierings, L Vindeløv and P thor Straten
Leukemia advance online publication, April 10, 2008; doi:10.1038/leu.2008.75
BCR/ABL promotes accumulation of chromosomal aberrations induced by oxidative and genotoxic stress
M Koptyra, K Cramer, A Slupianek, C Richardson and T Skorski
Leukemia advance online publication, April 10, 2008; doi:10.1038/leu.2008.78
STAT6 activity is regulated by SOCS-1 and modulates BCL-XL expression in primary mediastinal B-Cell lymphoma
O Ritz, C Guiter, K Dorsch, I Dusanter-Fourt, S Wegener, H Jouault, P Gaulard, F Castellano, P Möller and K Leroy
Leukemia advance online publication, April 10, 2008; doi:10.1038/leu.2008.85
April 3 2008
Letters to the Editor
Two cell lines of t(8;21) acute myeloid leukemia with activating KIT exon 17 mutation: models for the 'second hit' hypothesis
H Becker, D Pfeifer, J D Afonso, S D Nimer, H Veelken, M Schwabe and M Lübbert
Leukemia advance online publication, April 3, 2008; doi:10.1038/leu.2008.61