ACCEPTED ARTICLE PREVIEW

Latest accepted manuscripts for publication in Leukemia.
These manuscripts will undergo copyediting, typesetting and a proof review before being published in their final form.
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May 26 2017

Original Articles

A phase 1b/2b multicenter study of oral panobinostat plus azacitidine in adults with MDS, CMML, or AML with less than or equal to 30% blasts Open

G Garcia-Manero, M A Sekeres, M Egyed, M Breccia, C Graux, J D Cavenagh, H Salman, A Illes, P Fenaux, D J DeAngelo, R Stauder, K Yee, N Zhu, J-H Lee, D Valcarcel, A MacWhannell, Z Borbenyi, L Gazi, S Acharyya, S Ide, M Marker and O G Ottmann

Leukemia doi:10.1038/leu.2017.159; accepted article preview online May 26, 2017

Control of amino-acid transport coordinates metabolic reprogramming in T cell malignancy Open

K M Grzes, M Swamy, J L Hukelmann, E Emslie, L V Sinclair and D A Cantrell

Leukemia doi:10.1038/leu.2017.160; accepted article preview online May 26, 2017

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May 25 2017

Original Article

Age-related clinical and biological features of PTEN abnormalities in T-cell acute lymphoblastic leukaemia

M Tesio, A Trinquand, P Ballerini, G Hypolite, L Lhermitte, A Petit, N Ifrah, A Baruchel, H Dombret, E Macintyre and V Asnafi

Leukemia doi:10.1038/leu.2017.157; accepted article preview online May 25, 2017

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May 23 2017

Original Article

Proteomic analysis of JAK2V617F induced changes identifies potential new combinatorial therapeutic approaches

S Pearson, A J K Williamson, R Blance, T C P Somervaille, S Taylor, N Azadbakht, A D Whetton and A Pierce

Leukemia doi:10.1038/leu.2017.143; accepted article preview online May 23, 2017

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May 22 2017

Reviews

Assessing the thrombotic risk of patients with essential thrombocythemia in the genomic Era

L Falchi, H M Kantarjian and S Verstovsek

Leukemia doi:10.1038/leu.2017.150; accepted article preview online May 22, 2017

A revisionist history of adult marrow stem cell biology or ‘They forgot about the discard’

P Quesenberry and L Goldberg

Leukemia doi:10.1038/leu.2017.155; accepted article preview online May 22, 2017

Original Articles

Impact of killer-immunoglobulin-like receptor and human leukocyte antigen genotypes on the efficacy of immunotherapy in acute myeloid leukemia Open

E Bernson, A Hallner, F E Sander, O Wilsson, O Werlenius, A Rydström, R Kiffin, M Brune, R Foà, J Aurelius, A Martner, K Hellstrand and F B Thorén

Leukemia doi:10.1038/leu.2017.151; accepted article preview online May 22, 2017

Genetic deletion of sost or pharmacological inhibition of sclerostin prevent multiple myeloma-induced bone disease without affecting tumor growth

J Delgado-Calle, J Anderson, M D Cregor, K W Condon, S A Kuhstoss, L I Plotkin, T Bellido and G D Roodman

Leukemia doi:10.1038/leu.2017.152; accepted article preview online May 22, 2017

Letters to the Editor

An unusual, activating insertion/deletion MPL mutant in primary myelofibrosis

J-P Defour, Y Hoade, A-M Reuther, A Callaway, D Ward, F Chen, S N Constantinescu and N C P Cross

Leukemia doi:10.1038/leu.2017.153; accepted article preview online May 22, 2017

Prognostic impact of IKZF1 deletions in association with vincristine-dexamethasone pulses during maintenance treatment of childhood acute lymphoblastic leukemia on trial ALL-BFM 95 Open

L Hinze, A Möricke, M Zimmermann, S Junk, G Cario, E Dagdan, C P Kratz, V Conter, M Schrappe and M Stanulla

Leukemia doi:10.1038/leu.2017.154; accepted article preview online May 22, 2017

A critical role of periostin in B-cell acute lymphoblastic leukemia Open

Z Ma, X Zhao, J Huang, X Jia, M Deng, D Cui, Z Du, G Fu, G Ouyang and C Xiao

Leukemia doi:10.1038/leu.2017.149; accepted article preview online May 22, 2017

Spotlight on pomalidomide: Could less be more? Open

T J Zander, S Aebi, T Pabst, C Renner and C Driessen

Leukemia doi:10.1038/leu.2017.156; accepted article preview online May 22, 2017

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May 15 2017

Review

Why are hematopoietic stem cells so ‘sexy’?—on a search for developmental explanation Open

Mariusz Z Ratajczak

Leukemia doi:10.1038/leu.2017.148; accepted article preview online May 15, 2017

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May 12 2017

Letter to the Editor

Targeting FLT3 by chimeric antigen receptor T cells for the treatment of acute myeloid leukemia

L Chen, H Mao, J Zhang, J Chu, S Devine, M A Caligiuri and J Yu

Leukemia doi:10.1038/leu.2017.147; accepted article preview online May 12, 2017

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May 11 2017

Original Articles

Leptin receptor antagonism of iNKT cell function: a novel strategy to combat multiple myeloma

M Favreau, E Menu, D Gaublomme, K Vanderkerken, S Faict, K Maes, E De Bruyne, S Govindarajan, M Drennan, S Van Calenbergh, X Leleu, L Zabeau, J Tavernier, K Venken and D Elewaut

Leukemia doi:10.1038/leu.2017.146; accepted article preview online May 11, 2017

HDAC3 regulates DNMT1 expression in multiple myeloma: Therapeutic implications

T Harada, H Ohguchi, Y Grondin, S Kikuchi, M Sagawa, Y-T Tai, R Mazitschek, T Hideshima and K C Anderson

Leukemia doi:10.1038/leu.2017.144; accepted article preview online May 11, 2017

High efficacy and safety of low dose CD19-directed CAR-T cell therapy in 51 refractory or relapsed B acute lymphoblastic leukemia patients

J Pan, J Yang, B Deng, X Zhao, X Zhang, Y Lin, Y Wu, Z Deng, Y Zhang, S Liu, T Wu, P Lu, D Lu, A H Chang and C Tong

Leukemia doi:10.1038/leu.2017.145; accepted article preview online May 11, 2017

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May 10 2017

Original Articles

Abundant and equipotent founder cells establish and maintain acute lymphoblastic leukaemia Open

A Elder, S Bomken, I Wilson, H J Blair, S Cockell, F Ponthan, K Dormon, D Pal, O Heidenreich and J Vormoor

Leukemia doi:10.1038/leu.2017.140; accepted article preview online May 10, 2017

KDM6B modulates MAPK pathway mediating multiple myeloma cell growth and survival

H Ohguchi, T Harada, M Sagawa, S Kikuchi, Y-T Tai, P G Richardson, T Hideshima and K C Anderson

Leukemia doi:10.1038/leu.2017.141; accepted article preview online May 10, 2017

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May 9 2017

Original Articles

JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias Open

C Delgado-Martin, L K Meyer, B J Huang, K A Shimano, M S Zinter, J V Nguyen, G A Smith, J Taunton, S S Winter, J R Roderick, M A Kelliher, T M Horton, B L Wood, D Teachey and M L Hermiston

Leukemia doi:10.1038/leu.2017.136; accepted article preview online May 9, 2017

RNA editing signature during myeloid leukemia cell differentiation Open

C Rossetti, E Picardi, M Ye, G Camilli, A M D’Erchia, L Cucina, F Locatelli, L Fianchi, L Teofili, G Pesole, A Gallo and R Sorrentino

Leukemia doi:10.1038/leu.2017.134; accepted article preview online May 9, 2017

MicroRNA-146a reduces MHC-II expression via targeting JAK/STAT-signaling in dendritic cells after stem cell transplantation

N Stickel, K Hanke, D Marschner, G Prinz, M Köhler, W Melchinger, D Pfeifer, A Schmitt-Graeff, T Brummer, A Heine, P Brossart, D Wolf, N von Bubnoff, J Finke, J Duyster, J Ferrara, U Salzer and R Zeiser

Leukemia doi:10.1038/leu.2017.137; accepted article preview online May 9, 2017

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May 8 2017

Original Article

A novel agent SL-401 induces anti-myeloma activity by targeting plasmacytoid dendritic cells, osteoclastogenesis, and cancer stem-like cells

A Ray, D S Das, Y Song, V Macri, P Richardson, C L Brooks, D Chauhan and K C Anderson

Leukemia doi:10.1038/leu.2017.135; accepted article preview online May 8, 2017

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May 3 2017

Original Articles

Wnt5a induces ROR1 to complex with HS1 to enhance migration of chronic lymphocytic leukemia cells Open

K Hasan, J Yu, L Chen, B Cui, G F Widhopf, L Rassenti, Z Shen, S P Briggs and T J Kipps

Leukemia doi:10.1038/leu.2017.133; accepted article preview online May 3, 2017

Wnt5a induces ROR1 to associate with 14-3-3ζ for enhanced chemotaxis and proliferation of chronic lymphocytic leukemia cells Open

J Yu, L Chen, Y Chen, K Hasan, E M Ghia, L Zhang, R Wu, L Z Rassenti, G F Widhopf, Z Shen, S P Briggs and T J Kipps

Leukemia doi:10.1038/leu.2017.132; accepted article preview online May 3, 2017

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May 2 2017

Original Article

Targeting antigen-independent proliferation in chronic lymphocytic leukemia through differential kinase inhibition

E Slinger, R Thijssen, A P Kater and E Eldering

Leukemia doi:10.1038/leu.2017.129; accepted article preview online May 2, 2017

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April 25 2017

Original Articles

Efficacy and safety of carfilzomib regimens in multiple myeloma patients relapsing after autologous stem cell transplant: ASPIRE and ENDEAVOR outcomes Open

P Hari, M-V Mateos, R Abonour, S Knop, W Bensinger, H Ludwig, K Song, R Hajek, P Moreau, D S Siegel, S Feng, M Obreja, S K Aggarwal, K Iskander and H Goldschmidt

Leukemia doi:10.1038/leu.2017.122; accepted article preview online April 25, 2017

E-selectin ligands recognised by HECA452 induce drug resistance in myeloma, which is overcome by the E-selectin antagonist, GMI-1271 Open

A Natoni, T A G Smith, N Keane, C McEllistrim, C Connolly, A Jha, M Andrulis, E Ellert, M S Raab, S V Glavey, L Kirkham-McCarthy, S K Kumar, S C Locatelli-Hoops, I Oliva, W E Fogler, J L Magnani and M E O'Dwyer

Leukemia doi:10.1038/leu.2017.123; accepted article preview online April 25, 2017

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