TABLE OF CONTENTS
Volume 21, Issue 10 (October 2007)
Editorial
Macrophages and tumor angiogenesis
D Ribatti, B Nico, E Crivellato and A Vacca
Leukemia 21: 2085-2089; doi:10.1038/sj.leu.2404900
Mouse models and the RANKL/OPG axis in myeloma bone disease
D Dingli and S J Russell
Leukemia 21: 2090-2093; doi:10.1038/sj.leu.2404875
Review
ATP-binding-cassette transporters in hematopoietic stem cells and their utility as therapeutical targets in acute and chronic myeloid leukemia
M H G P Raaijmakers
Leukemia 21: 2094-2102; advance online publication, July 26, 2007; doi:10.1038/sj.leu.2404859
Original Articles
Molecular Targets for Therapy
Regulation of the expression of MHC class I-related chain A, B (MICA, MICB) via chromatin remodeling and its impact on the susceptibility of leukemic cells to the cytotoxicity of NKG2D-expressing cells
N Kato, J Tanaka, J Sugita, T Toubai, Y Miura, M Ibata, Y Syono, S Ota, T Kondo, M Asaka and M Imamura
Leukemia 21: 2103-2108; advance online publication, July 12, 2007; doi:10.1038/sj.leu.2404862
Therapy
Comparison between two fludarabine-based reduced-intensity conditioning regimens before allogeneic hematopoietic stem-cell transplantation: fludarabine/melphalan is associated with higher incidence of acute graft-versus-host disease and non-relapse mortality and lower incidence of relapse than fludarabine/busulfan
A Shimoni, I Hardan, N Shem-Tov, A Rand, C Herscovici, R Yerushalmi and A Nagler
Leukemia 21: 2109-2116; advance online publication, August 9, 2007; doi:10.1038/sj.leu.2404886
Trolox enhances the anti-lymphoma effects of arsenic trioxide, while protecting against liver toxicity
Z Diaz, A Laurenzana, K K Mann, T A Bismar, H M Schipper and W H Miller Jr
Leukemia 21: 2117-2127; advance online publication, August 9, 2007; doi:10.1038/sj.leu.2404891
Acute Leukemias
Genome scan implicates adhesion biological pathways in secondary leukemia
C Hartford, W Yang, C Cheng, Y Fan, W Liu, L Treviño, S Pounds, G Neale, S C Raimondi, A Bogni, M E Dolan, C-H Pui and M V Relling
Leukemia 21: 2128-2136; advance online publication, August 2, 2007; doi:10.1038/sj.leu.2404885
Combined high-resolution array-based comparative genomic hybridization and expression profiling of ETV6/RUNX1-positive acute lymphoblastic leukemias reveal a high incidence of cryptic Xq duplications and identify several putative target genes within the commonly gained region
H Lilljebjörn, M Heidenblad, B Nilsson, C Lassen, A Horvat, J Heldrup, M Behrendtz, B Johansson, A Andersson and T Fioretos
Leukemia 21: 2137-2144; advance online publication, August 9, 2007; doi:10.1038/sj.leu.2404879
Rapid natural killer cell recovery determines outcome after T-cell-depleted HLA-identical stem cell transplantation in patients with myeloid leukemias but not with acute lymphoblastic leukemia
B N Savani, S Mielke, S Adams, M Uribe, K Rezvani, A S M Yong, J Zeilah, R Kurlander, R Srinivasan, R Childs, N Hensel and A J Barrett
Leukemia 21: 2145-2152; advance online publication, August 2, 2007; doi:10.1038/sj.leu.2404892
Chronic Lymphocytic Leukemia
Combined single nucleotide polymorphism-based genomic mapping and global gene expression profiling identifies novel chromosomal imbalances, mechanisms and candidate genes important in the pathogenesis of T-cell prolymphocytic leukemia with inv(14)(q11q32)
J Dürig, S Bug, L Klein-Hitpass, T Boes, T Jöns, J I Martin-Subero, L Harder, M Baudis, U Dührsen and R Siebert
Leukemia 21: 2153-2163; advance online publication, August 16, 2007; doi:10.1038/sj.leu.2404877
Oncogenes Fusion Genes and Tumor Suppressor Genes
Effective treatment of leukemic cell lines with wt1 siRNA
W Glienke, L Maute, U Koehl, R Esser, E Milz and L Bergmann
Leukemia 21: 2164-2170; advance online publication, August 9, 2007; doi:10.1038/sj.leu.2404878
Animal Models
Remarkable leukemogenic potency and quality of a constitutively active neurotrophin receptor, 
TrkA
J Meyer, M Rhein, B Schiedlmeier, O Kustikova, C Rudolph, K Kamino, T Neumann, M Yang, A Wahlers, B Fehse, G W Reuther, B Schlegelberger, A Ganser, C Baum and Z Li
Leukemia 21: 2171-2180; advance online publication, August 2, 2007; doi:10.1038/sj.leu.2404882
Myeloma
A new xenograft model of myeloma bone disease demonstrating the efficacy of human mesenchymal stem cells expressing osteoprotegerin by lentiviral gene transfer
N Rabin, C Kyriakou, L Coulton, O M Gallagher, C Buckle, R Benjamin, N Singh, J Glassford, T Otsuki, A C Nathwani, P I Croucher and K L Yong
Leukemia 21: 2181-2191; advance online publication, July 26, 2007; doi:10.1038/sj.leu.2404814
Letters to the Editor
Splenectomy: a new treatment option for ALL tumors expressing Hox-11 and a means to test the stem cell hypothesis of cancer in humans
F J Dieguez-Acuna, S P Gygi, M Davis and D L Faustman
Leukemia 21: 2192-2194; advance online publication, August 16, 2007; doi:10.1038/sj.leu.2404927
Haematological malignancies in developing countries: is CML the commonest childhood leukaemia?
A D Wechalekar and C M Parande
Leukemia 21: 2194; advance online publication, August 2, 2007; doi:10.1038/sj.leu.2404880
Reply to 'Haematological malignancies in developing countries—is CML the commonest childhood leukaemia?' by Dr Ashutosh Wechalekar and Dr Chandrakant Parande
J L Gajewski
Leukemia 21: 2195; advance online publication, August 2, 2007; doi:10.1038/sj.leu.2404881
DNA damage check points prevent leukemic transformation in myelodysplastic syndrome
S Horibe, M Takagi, J Unno, M Nagasawa, T Morio, A Arai, O Miura, M Ohta, M Kitagawa and S Mizutani
Leukemia 21: 2195-2198; advance online publication, May 10, 2007; doi:10.1038/sj.leu.2404748
AML1–ETO meets JAK2: clinical evidence for the two hit model of leukemogenesis from a myeloproliferative syndrome progressing to acute myeloid leukemia
F Schneider, S K Bohlander, S Schneider, C Papadaki, P Kakadyia, A Dufour, S Vempati, M Unterhalt, M Feuring-Buske, C Buske, J Braess, H Wandt, W Hiddemann and K Spiekermann
Leukemia 21: 2199-2201; advance online publication, July 12, 2007; doi:10.1038/sj.leu.2404830
Morphometry and mathematical modelling of the capillary-like patterns formed in vitro by bone marrow macrophages of patients with multiple myeloma
D Guidolin, B Nico, A S Belloni, G G Nussdorfer, A Vacca and D Ribatti
Leukemia 21: 2201-2203; advance online publication, May 24, 2007; doi:10.1038/sj.leu.2404771
Treatment outcome in adults with acute lymphoblastic leukemia: 50% long-term disease-free survival
G E Tjønnfjord, T Gedde-Dahl III, D Heldal and L Brinch
Leukemia 21: 2203-2204; advance online publication, May 24, 2007; doi:10.1038/sj.leu.2404751
BCR-ABL T315I transcript disappearance in an imatinib-resistant CML patient treated with homoharringtonine: a new therapeutic challenge?
L Legros, S Hayette, F E Nicolini, S Raynaud, K Chabane, J-P Magaud, J-P Cassuto and M Michallet
Leukemia 21: 2204-2206; advance online publication, May 31, 2007; doi:10.1038/sj.leu.2404772
Demonstration of MPLW515K, but not JAK2V617F, in in vitro expanded CD4+ T lymphocytes
A Pardanani, T L Lasho, C Finke, S N Markovic and A Tefferi
Leukemia 21: 2206-2207; advance online publication, May 17, 2007; doi:10.1038/sj.leu.2404749
EBV-positive lymphoproliferative disease with medullary, splenic and hepatic infiltration after imatinib mesylate therapy for chronic myeloid leukemia
T Leguay, C Foucaud, M Parrens, O Fitoussi, K Bouabdallah, M A Belaud-Rotureau, R Tabrizi, G Marit, A Pigneux and N Milpied
Leukemia 21: 2208-2210; advance online publication, May 31, 2007; doi:10.1038/sj.leu.2404758
The quantitative JAK2 V617F neutrophil allele burden does not correlate with thrombotic risk in essential thrombocytosis
N Pemmaraju, A R Moliterno, D M Williams, O Rogers and J L Spivak
Leukemia 21: 2210-2212; advance online publication, May 17, 2007; doi:10.1038/sj.leu.2404755
Human erythroleukemia: is the two-hit model of mouse leukemogenesis valid in human disease?
S Coulon, J Vandekerckhove, M Dussiot, C Callens, F Suarez, J Kersual, V Asnafi, Z Belaid, G Courtois, S Giraudier, P Dubreuil, Y Lepelletier, I C Moura and O Hermine
Leukemia 21: 2212-2214; advance online publication, May 31, 2007; doi:10.1038/sj.leu.2404779
Donor-derived mucosal epithelial cells after human hematopoietic cell transplantation are not derived from the CD34-positive fraction of the graft
Y Metaxas, A Spyridonidis, H Bertz, J Finke and J Greiner
Leukemia 21: 2214-2216; advance online publication, May 31, 2007; doi:10.1038/sj.leu.2404759
The T1790A BRAF mutation (L597Q) in childhood acute lymphoblastic leukemia is a functional oncogene
P Hou, D Liu and M Xing
Leukemia 21: 2216-2218; advance online publication, May 24, 2007; doi:10.1038/sj.leu.2404761
N822 mutation of KIT gene was frequent in pediatric acute myeloid leukemia patients with t(8;21) in Japan: a study of the Japanese childhood AML cooperative study group
A Shimada, T Taki, C Kubota, T Itou, A Tawa, K Horibe, M Tsuchida, R Hanada, I Tsukimoto and Y Hayashi
Leukemia 21: 2218-2219; advance online publication, May 24, 2007; doi:10.1038/sj.leu.2404766
A new partner gene fused to ABL1 in a t(1;9)(q24;q34)-associated B-cell acute lymphoblastic leukemia
E De Braekeleer, N Douet-Guilbert, M-J Le Bris, C Berthou, F Morel and M De Braekeleer
Leukemia 21: 2220-2221; advance online publication, May 31, 2007; doi:10.1038/sj.leu.2404773
Upregulation of the SOX5 by promoter swapping with the P2RY8 gene in primary splenic follicular lymphoma
C T Storlazzi, F Albano, C Lo Cunsolo, C Doglioni, M C Guastadisegni, L Impera, A Lonoce, S Funes, E Macrì, P Iuzzolino, I Panagopoulos, G Specchia and M Rocchi
Leukemia 21: 2221-2225; advance online publication, June 7, 2007; doi:10.1038/sj.leu.2404784
Fludarabine, mitoxantrone and dexamethasone as first-line treatment for T-cell large granular lymphocyte leukemia
E Tse, J C W Chan, A Pang, W-Y Au, A Y H Leung, C C K Lam and Y-L Kwong
Leukemia 21: 2225-2226; advance online publication, May 24, 2007; doi:10.1038/sj.leu.2404767
Polymorphisms in the DNA ligase IV gene might influence the risk of acute lymphoblastic leukemia in children
J Andreae, R Varon, K Sperling and K Seeger
Leukemia 21: 2226-2227; advance online publication, May 31, 2007; doi:10.1038/sj.leu.2404783
Absolute lymphocyte counts predicts response to chemotherapy and survival in diffuse large B-cell lymphoma
D H Kim, J H Baek, Y S Chae, Y-K Kim, H J Kim, Y H Park, H S Song, J S Chung, M S Hyun and S K Sohn
Leukemia 21: 2227-2230; advance online publication, June 7, 2007; doi:10.1038/sj.leu.2404780
Adult ALL: treatment outcome and prognostic factors in an Indian population using a modified German ALL (GMALL) protocol
A Bajel, B George, V Mathews, A Viswabandya, M L Kavitha, A Srivastava and M Chandy
Leukemia 21: 2230-2233; advance online publication, June 7, 2007; doi:10.1038/sj.leu.2404785
Induction of folate receptor type 
in a bone marrow engraftment model of acute myelogenous leukemia
B W Blaser, M Gonit, H Qi, A Shatnawi, M Guimond, R J Lee and M Ratnam
Leukemia 21: 2233-2235; advance online publication, June 7, 2007; doi:10.1038/sj.leu.2404786
