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Bax gene G(-248)A promoter polymorphism and chronic lymphocytic leukemia: lack of association with incidence, disease stage and progression-free survival

Leukemia volume 20, page 724 (2006)Cite this article

Recently, Starczynski et al.1 described an association of genotypes of the G(-248)A polymorphism located in the promoter region of the bax gene with low Bax expression, more advanced stage, treatment resistance and short overall survival in B-cell chronic lymphocytic leukemia (CLL). Given the key role of apoptosis for the progression of B-CLL, multiple studies have investigated and confirmed the potential role of the Bcl-2 family proteins.2, 3

In this context, a functional single nucleotide polymorphism in the bax gene, which alters protein function and/or expression, could influence the delicate balance of mechanisms, which regulate apoptosis and thereby impact upon the natural course of CLL. However, related findings from genetic association studies require conformation in independent samples before being universally acceptable.

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Figure 1

References

  1. Starczynski J, Pepper C, Pratt G, Hooper L, Thomas A, Milligan D et al. Common polymorphism G(−248)A in the promoter region of the bax gene results in significantly shorter survival in patients with chronic lymphocytic Leukemia once treatment is initiated. J Clin Oncol 2005; 23: 1514–1521.

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  2. Schena M, Larsson LG, Gottardi D, Gaidano G, Carlsson M, Nilsson K et al. Growth- and differentiation-associated expression of bcl-2 in B-chronic lymphocytic leukemia cells. Blood 1992; 79: 2981–2989.

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Authors and Affiliations

  1. Department of Hematology, Medical Faculty, University of Essen, Essen, Germany

    H Nückel, L Sellmann, J Dürig & U Dührsen

  2. Institute of Pharmagenetics, Medical Faculty, University of Essen, Essen, Germany

    H Nückel, U H Frey, M Bau & W Siffert

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  1. H Nückel
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  2. U H Frey
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  3. L Sellmann
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  4. M Bau
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  5. J Dürig
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  6. U Dührsen
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  7. W Siffert
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Correspondence to H Nückel.

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Nückel, H., Frey, U., Sellmann, L. et al. Bax gene G(-248)A promoter polymorphism and chronic lymphocytic leukemia: lack of association with incidence, disease stage and progression-free survival. Leukemia 20, 724 (2006). https://doi.org/10.1038/sj.leu.2404126

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