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Increase of CCR7− CD45RA+ CD8 T cells (TEMRA) in chronic graft-versus-host disease

Leukemia volume 20, pages 545–547 (2006)Cite this article

Among the late effects of hematopoietic stem cell transplantation (HSCT), chronic graft-vs-host disease (cGVHD) still remains as the major determinant of long-term outcome and quality of life. The disease typically appears between 3 months to 1.5 years following an allogeneic transplantation and is characterized by symptoms similar to those of autoimmune disease.

GVHD is caused by donor CD4 and CD8 T cell-mediated anti-host reaction that evolves over several weeks to months, suggesting a requirement for persistent alloreactive T cells.

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Authors and Affiliations

  1. Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo, Corso Tukory 211, Palermo, Italy

    M D'Asaro, F Dieli, N Caccamo & A Salerno

  2. Dipartimento di Oncoematologia, Ospedale La Maddalena, Palermo, Italy

    M Musso & F Porretto

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  1. M D'Asaro
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  2. F Dieli
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D'Asaro, M., Dieli, F., Caccamo, N. et al. Increase of CCR7− CD45RA+ CD8 T cells (TEMRA) in chronic graft-versus-host disease. Leukemia 20, 545–547 (2006). https://doi.org/10.1038/sj.leu.2404079

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