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Untreated essential thrombocythemia evolving to biphenotypic leukemia, Philadelphia chromosome positive with monosomy 7: response to imatinib and reduced-intensity allogeneic stem cell transplant

Leukemia volume 19, pages 1095–1096 (2005)Cite this article

TO THE EDITOR

Essential thrombocythemia (ET), characterized by elevated platelet count with increased tendency to thrombosis and hemorrhage, lacks features diagnostic for other myeloproliferative disorders including the Philadelphia (Ph+) chromosome translocation.1 The clinical course of ET shows a low rate of transformation to acute leukemia, even when the onset of the disease occurs at a young age.2

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Authors and Affiliations

  1. Helen F Graham Cancer Center, Newark, DE, USA

    S E Martin

  2. Department of Medicine, Christiana Care, Newark, DE, USA

    S E Martin & J DellaValla

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  1. S E Martin
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  2. J DellaValla
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Correspondence to S E Martin.

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Martin, S., DellaValla, J. Untreated essential thrombocythemia evolving to biphenotypic leukemia, Philadelphia chromosome positive with monosomy 7: response to imatinib and reduced-intensity allogeneic stem cell transplant. Leukemia 19, 1095–1096 (2005). https://doi.org/10.1038/sj.leu.2403725

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