Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

Role of USF1 in the differential expression of the human deoxycytidine kinase gene in acute myeloid leukemia

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2
Figure 3

References

  1. Galmarini CM, Mackey JR, Dumontet C . Nucleoside analogues: mechanisms of drug resistance and reversal strategies. Leukemia 2001; 15: 875–890.

    Article  CAS  Google Scholar 

  2. Galmarini CM, Thomas X, Graham K, El Jafaari A, Cros E, Jordheim L et al. Deoxycytidine kinase and cN-II nucleotidase expression in blast cells predict survival in acute myeloid leukaemia patients treated with cytarabine. Br J Haematol 2003; 122: 53–60.

    Article  CAS  Google Scholar 

  3. Veuger MJ, Honders MW, Willemze R, Barge RM . Deoxycytidine kinase expression and activity in patients with resistant versus sensitive acute myeloid leukemia. Eur J Haematol 2002; 69: 171–178.

    Article  CAS  Google Scholar 

  4. Chen EH, Johnson EE, Vetter SM, Mitchell BS . Characterization of the deoxycytidine kinase promoter in human lymphoblast cell lines. J Clin Invest 1995; 95: 1660–1668.

    Article  CAS  Google Scholar 

  5. Ge Y, Jensen TL, Matherly LH, Taub JW . Physical and functional interactions between usf and sp1 proteins regulate human deoxycytidine kinase promoter activity. J Biol Chem 2003; 278: 49901–49910.

    Article  CAS  Google Scholar 

  6. Ge Y, Stout ML, Tatman DA, Jensen TL, Buck S, Thomas RL et al. GATA1, cytidine deaminase and the high cure rate of Down syndrome children with acute megakaryocytic leukemia. J Natl Cancer Inst 2005; 97: 226–231.

    Article  CAS  Google Scholar 

  7. Taub JW, Huang X, Matherly LH, Stout ML, Buck SA, Massey GV et al. Expression of chromosome 21-localized genes in acute myeloid leukemia: differences between Down Syndrome and non-Down Syndrome blast cells and relationship to in vitro sensitivity to cytosine arabinoside and daunorubicin. Blood 1999; 94: 1393–1400.

    CAS  Google Scholar 

  8. Ge Y, Jensen TL, Stout ML, Flatley RM, Grohar P, Ravindranath Y et al. The role of cytidine deaminase and GATA1 mutations in the increased cytosine arabinoside sensitivity of Down syndrome myeloblasts and leukemia cell lines. Cancer Res 2004; 64: 728–735.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by grant RO1 CA92308 from the National Cancer Institute, The Leukemia and Lymphoma Society, Children's Research Center of Michigan, BPCT and Justin's Gift Golf Charities, The Elana Fund and Leukemia, Research, Life, Inc. JWT is a Scholar in Clinical Research of the Leukemia and Lymphoma Society. YG is a recipient of the National Down Syndrome Society's Charles J Epstein Research Award and the Children's Research Center of Michigan Research Award.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to J W Taub.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ge, Y., Jensen, T., Tatman, D. et al. Role of USF1 in the differential expression of the human deoxycytidine kinase gene in acute myeloid leukemia. Leukemia 19, 677–679 (2005). https://doi.org/10.1038/sj.leu.2403666

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.leu.2403666

This article is cited by

Search

Quick links